The glycoprotein GPNMB is selectively elevated in the substantia nigra of Parkinson's disease patients and increases after lysosomal stress
Sign Up to like & getrecommendations! Published in 2018 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2018.08.013
Abstract: GPNMB is a glycoprotein observed upon tissue damage and inflammation and is associated with astrocytes, microglia, and macrophages. Gene variations in GPNMB are linked with Parkinson's disease (PD) risk, and changes in protein levels of… read more here.
Keywords: disease; substantia nigra; parkinson disease; gpnmb ... See more keywords
Association of three candidate genetic variants in ACMSD/TMEM163, GPNMB and BCKDK /STX1B with sporadic Parkinson’s disease in Han Chinese
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2019.03.019
Abstract: Large-scale meta-analyses of genome-wide association studies have identified that polymorphisms ACMSD/TMEM163 rs6430538, GPNMB rs199347 and BCKDK /STX1B rs14235 to be the risk loci for Parkinson's disease (PD) in a Caucasian population. However, the role of… read more here.
Keywords: gpnmb; acmsd tmem163; bckdk stx1b; han chinese ... See more keywords
GPNMB is expressed in human epidermal keratinocytes but disappears in the vitiligo lesional skin
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-61931-1
Abstract: GPNMB is involved in multiple cellular functions including cell adhesion, stress protection and stem cell maintenance. In skin, melanocyte-GPNMB is suggested to mediate pigmentation through melanosome formation, but details of keratinocyte-GPNMB have yet to be… read more here.
Keywords: epidermal keratinocytes; skin; human epidermal; expression ... See more keywords
Expression pattern and prognostic impact of glycoprotein non-metastatic B (GPNMB) in triple-negative breast cancer
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DOI: 10.1038/s41598-021-91588-3
Abstract: Glycoprotein non-metastatic B (GPNMB) is a transmembrane protein overexpressed in numerous cancers including triple-negative breast cancers (TNBC). It has been linked to promote cancer aggressiveness and implicated as a novel target for GPNMB-expressing cancers. In… read more here.
Keywords: glycoprotein non; tnbc; metastatic gpnmb; expression ... See more keywords
Anti-inflammatory role of Gpnmb in adipose tissue of mice
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DOI: 10.1038/s41598-021-99090-6
Abstract: Obesity can cause a chronic, low-grade inflammation, which is a critical step in the development of type II diabetes and cardiovascular diseases. Inflammation is associated with the expression of glycoprotein nonmetastatic melanoma protein b (Gpnmb),… read more here.
Keywords: inflammation; adipose tissue; gpnmb; obesity ... See more keywords
Macrophage‐derived GPNMB accelerates skin healing
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Dermatology"
DOI: 10.1111/exd.13524
Abstract: Healing is a vital response important for the re‐establishment of the skin integrity following injury. Delayed or aberrant dermal wound healing leads to morbidity in patients. The development of therapies to improve dermal healing would… read more here.
Keywords: accelerates skin; macrophage derived; derived gpnmb; gpnmb accelerates ... See more keywords
Toward preventing Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2022 at "Science"
DOI: 10.1126/science.add7162
Abstract: Description A glycoprotein is a possible biomarker of pathogenic progression for Parkinson’s disease The diagnosis of Parkinson’s disease (PD) relies on the presence of motor symptoms that occur when 50 to 70% of dopaminergic neurons… read more here.
Keywords: disease; parkinson disease; preventing parkinson; gpnmb ... See more keywords
AB0103 A NOVEL PROTECTIVE ROLE OF GPNMB/OSTEOACTIVIN IN POST-TRAUMATIC OSTEOARTHRITIS
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2019-eular.8175
Abstract: Background: Osteoarthritis (OA) is a chronic joint disease causes irreversible damage to the articular cartilage resulting in loss of joint function and subchondral bone remodeling. There is no cure for OA and currently the available… read more here.
Keywords: osteoarthritis; gpnmb osteoactivin; role; gpnmb ... See more keywords
The role of Glycoprotein Nonmetastatic Melanoma Protein B in vascular inflammation during infectious challenge
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DOI: 10.1152/physiol.2023.38.s1.5734455
Abstract: Glycoprotein nonmetastatic melanoma protein B (GPNMB) is a transmembrane glycoprotein that has been shown to play an important role in inflammation. GPNMB levels are increased in association with pro-inflammatory conditions, such as lipopolysaccharide exposure. Further,… read more here.
Keywords: endothelial cells; role; physiology; gpnmb ... See more keywords
Abstract 1154: Investigating the functional role of GPNMB in glioblastoma and the tumor immune microenvironment and its targeted elimination using CAR-Ts
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1154
Abstract: Glycoprotein nonmetastatic melanoma protein B (GPNMB) is known to be active in the extracellular matrix of glioblastoma and has been identified as a promising immunotherapy target for both tumor cells and immunosuppressive macrophages. Methods: Immunohistochemistry… read more here.
Keywords: cell; immune microenvironment; car; gpnmb ... See more keywords
Abstract P3-07-03: GPNMB activates EGFR to overcome Mek-inhibition: Implications for the development of rational targeted therapy combinations in triple negative breast cancer
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs16-p3-07-03
Abstract: Background: TNBC is an aggressive subtype that constitutes ~15% of all BC. Currently there are no targeted therapies available for patients with. As such, there is much interest in developing targeted therapies for this disease.… read more here.
Keywords: mek; inhibition; tnbc; cancer ... See more keywords