Activation of microglial GPR109A alleviates thermal hyperalgesia in female lupus mice by suppressing IL‐18 and glutamatergic synaptic activity
Sign Up to like & getrecommendations! Published in 2021 at "Glia"
DOI: 10.1002/glia.24130
Abstract: Many patients with systemic lupus erythematosus (SLE) live with chronic pain despite advances in medical management in reducing mortality related to SLE. Few animal studies have addressed mechanisms and treatment for chronic pain caused by… read more here.
Keywords: gpr109a; activation; mice; glutamatergic synaptic ... See more keywords
Butyrate receptor HCAR2/GPR109A controls imiquimod-induced psoriasis-like skin inflammation.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of immunology"
DOI: 10.1093/jimmun/vkaf069
Abstract: Psoriasis is a chronic inflammatory skin disorder characterized by aberrant keratinocyte proliferation and immune cell infiltration with upregulation of inflammatory cytokines. Here, we examined the contribution of HCAR2 encoding for the short-chain fatty acid receptor… read more here.
Keywords: mice; imiquimod induced; butyrate; skin inflammation ... See more keywords
Glutamine metabolic competition drives immunosuppressive reprogramming of intratumour GPR109A+ myeloid cells to promote liver cancer progression
Sign Up to like & getrecommendations! Published in 2024 at "Gut"
DOI: 10.1136/gutjnl-2024-332429
Abstract: Objective The metabolic characteristics of liver cancer drive considerable hurdles to immune cells function and cancer immunotherapy. However, how metabolic reprograming in the tumour microenvironment impairs the antitumour immune response remains unclear. Design Human samples… read more here.
Keywords: myeloid cells; cancer; progression; liver cancer ... See more keywords
Abstract 3022: GPR109A activation limits cell growth by inducing p53 and its targets in human colon cancer cells
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-3022
Abstract: Chemical carcinogens or xenobiotics present in the diet play a significant role in colon cancer (CC) formation. p53, a tumor suppressor and multi-functional protein, provides an important barrier against the initiation and maintenance of CC.… read more here.
Keywords: cancer; cell lines; colon; p53 ... See more keywords
Structural and Energetic Insights Into the Interaction of Niacin With the GPR109A Receptor
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DOI: 10.1177/11779322211056122
Abstract: The transmembrane G-protein coupled receptor GPR109A has been previously shown to function as a receptor for niacin in mediating antilipolytic effects. Although administration of high doses of niacin has shown beneficial effects on lipid metabolism,… read more here.
Keywords: insights interaction; niacin gpr109a; structural energetic; gpr109a ... See more keywords
The Β-HYDROXYBUTYRATE-GPR109A Receptor Regulates Fasting-Induced Plasticity In The Mouse Adrenal Medulla.
Sign Up to like & getrecommendations! Published in 2022 at "Endocrinology"
DOI: 10.1210/endocr/bqac077
Abstract: During fasting, increased sympatho-adrenal activity leads to epinephrine release and multiple forms of plasticity within the adrenal medulla including an increase in the strength of the preganglionic → chromaffin cell synapse and elevated levels of… read more here.
Keywords: chromaffin; plasticity; hydroxybutyrate; gpr109a ... See more keywords
Niacin Improves Intestinal Health through Up-Regulation of AQPs Expression Induced by GPR109A
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23158332
Abstract: (1) Background: Changes in the expression of aquaporins (AQPs) in the intestine are proved to be associated with the attenuation of diarrhea. Diarrhea is a severe problem for postweaning piglets. Therefore, this study aimed to… read more here.
Keywords: cell; etec k88; expression; gpr109a ... See more keywords
Exploring GPR109A Receptor Interaction with Hippuric Acid Using MD Simulations and CD Spectroscopy
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232314778
Abstract: Previous research has indicated that various metabolites belonging to phenolic acids (PAs), produced by gut microflora through the breakdown of polyphenols, help in promoting bone development and protecting bone from degeneration. Results have also suggested… read more here.
Keywords: interaction; hippuric acid; spectroscopy; receptor ... See more keywords