Activation of microglial GPR109A alleviates thermal hyperalgesia in female lupus mice by suppressing IL‐18 and glutamatergic synaptic activity
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DOI: 10.1002/glia.24130
Abstract: Many patients with systemic lupus erythematosus (SLE) live with chronic pain despite advances in medical management in reducing mortality related to SLE. Few animal studies have addressed mechanisms and treatment for chronic pain caused by… read more here.
Keywords: gpr109a; activation; mice; glutamatergic synaptic ... See more keywords
Structural and Energetic Insights Into the Interaction of Niacin With the GPR109A Receptor
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DOI: 10.1177/11779322211056122
Abstract: The transmembrane G-protein coupled receptor GPR109A has been previously shown to function as a receptor for niacin in mediating antilipolytic effects. Although administration of high doses of niacin has shown beneficial effects on lipid metabolism,… read more here.
Keywords: insights interaction; niacin gpr109a; structural energetic; gpr109a ... See more keywords
The Β-HYDROXYBUTYRATE-GPR109A Receptor Regulates Fasting-Induced Plasticity In The Mouse Adrenal Medulla.
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DOI: 10.1210/endocr/bqac077
Abstract: During fasting, increased sympatho-adrenal activity leads to epinephrine release and multiple forms of plasticity within the adrenal medulla including an increase in the strength of the preganglionic → chromaffin cell synapse and elevated levels of… read more here.
Keywords: chromaffin; plasticity; hydroxybutyrate; gpr109a ... See more keywords
Niacin Improves Intestinal Health through Up-Regulation of AQPs Expression Induced by GPR109A
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DOI: 10.3390/ijms23158332
Abstract: (1) Background: Changes in the expression of aquaporins (AQPs) in the intestine are proved to be associated with the attenuation of diarrhea. Diarrhea is a severe problem for postweaning piglets. Therefore, this study aimed to… read more here.
Keywords: cell; etec k88; expression; gpr109a ... See more keywords
Exploring GPR109A Receptor Interaction with Hippuric Acid Using MD Simulations and CD Spectroscopy
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DOI: 10.3390/ijms232314778
Abstract: Previous research has indicated that various metabolites belonging to phenolic acids (PAs), produced by gut microflora through the breakdown of polyphenols, help in promoting bone development and protecting bone from degeneration. Results have also suggested… read more here.
Keywords: interaction; hippuric acid; spectroscopy; receptor ... See more keywords