DHA supplementation prevent the progression of NASH via GPR120 signaling
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2017.11.046
Abstract: ABSTRACT Nonalcoholic steatohepatitis (NASH) is one of the most common liver diseases involving chronic accumulation of fat and inflammation, often leading to advanced fibrosis, cirrhosis and carcinoma. However, the pathological mechanism for this is unknown.… read more here.
Keywords: cdahf diet; mice; gpr120; mice fed ... See more keywords
Indazole-6-phenylcyclopropylcarboxylic Acids as Selective GPR120 Agonists with in Vivo Efficacy.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.7b00210
Abstract: GPR120 agonists have therapeutic potential for the treatment of diabetes, but few selective agonists have been reported. We identified an indazole-6-phenylcyclopropylcarboxylic acid series of GPR120 agonists and conducted SAR studies to optimize GPR120 potency. Furthermore,… read more here.
Keywords: acids selective; indazole phenylcyclopropylcarboxylic; selective gpr120; gpr120 agonists ... See more keywords
GPR120 prevents colorectal adenocarcinoma progression by sustaining the mucosal barrier integrity
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-021-03787-7
Abstract: GPR120 (encoded by FFAR4 gene) is a receptor for long chain fatty acids, activated by ω-3 Polyunsaturated Fatty Acids (PUFAs), and expressed in many cell types. Its role in the context of colorectal cancer (CRC)… read more here.
Keywords: mucosal barrier; gpr120; barrier integrity; progression ... See more keywords
Insulinotropic effects of GPR120 agonists are altered in obese diabetic and obese non-diabetic states.
Sign Up to like & getrecommendations! Published in 2017 at "Clinical science"
DOI: 10.1042/cs20160545
Abstract: G-protein-coupled receptor 120 (GPR120) is a putative target for obesity and diabetes therapies. However, it remains controversial whether resident GPR120 plays a direct regulatory role in islet β-cell insulin secretion. The present study examined this… read more here.
Keywords: insulinotropic effects; expression; obese non; gpr120 ... See more keywords
GPR120 inhibits colitis through regulation of CD4+T cell IL-10 production.
Sign Up to like & getrecommendations! Published in 2021 at "Gastroenterology"
DOI: 10.1053/j.gastro.2021.09.018
Abstract: BACKGROUND & AIMS G protein-coupled receptor (GPR) 120 has been implicated in regulating metabolic syndromes with anti-inflammatory function. However, the role of GPR120 in intestinal inflammation is unknown. Here, we investigated whether and how GPR120… read more here.
Keywords: cd4; colitis; gpr120; cd4 cell ... See more keywords
Agonism of GPR120 Prevented High Glucose-Induced Apoptosis of Retinal Endothelial Cells through Inhibiting NLRP3 Inflammasome.
Sign Up to like & getrecommendations! Published in 2022 at "Klinische Monatsblatter fur Augenheilkunde"
DOI: 10.1055/a-1811-7099
Abstract: PURPOSE GPR120 has been reported to ameliorate inflammation in diabetes and diabetic complications. In this study, GW9508, the GPR120 agonist, was utilized in human retinal microvascular endothelial cells (HRMECs) exposed to high glucose (HG) to… read more here.
Keywords: endothelial cells; expression; detected western; high glucose ... See more keywords
GPR120 promotes neutrophil control of intestinal bacterial infection
Sign Up to like & getrecommendations! Published in 2023 at "Gut Microbes"
DOI: 10.1080/19490976.2023.2190311
Abstract: ABSTRACT G-protein coupled receptor 120 (GPR 120) has been implicated in anti-inflammatory functions. However, how GPR120 regulates the neutrophil function remains unknown. This study investigated the role of GPR120 in the regulation of neutrophil function… read more here.
Keywords: gpr120; infection; mice; citrobacter rodentium ... See more keywords
Effect of icosapent ethyl on susceptibility to ventricular arrhythmias in postinfarcted rat hearts: Role of GPR120‐mediated connexin43 phosphorylation
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.15575
Abstract: The ω‐3 fatty acids exert as an antioxidant via the G protein‐coupled receptor 120 (GPR120). Icosapent ethyl, a purified eicosapentaenoic acid, showed a marked reduction in sudden cardiac death. Connexin43 is sensitive to redox status.… read more here.
Keywords: icosapent ethyl; gpr120; connexin43; phosphorylation ... See more keywords
Docosahexaenoic Acid Attenuates the Progression of Nonalcoholic Steatohepatitis by Suppressing the Adipocyte Inflammation via the G Protein-Coupled Receptor 120/Free Fatty Acid Receptor 4 Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Pharmacology"
DOI: 10.1159/000522117
Abstract: Introduction: Our previous study demonstrated that docosahexaenoic acid (DHA), an endogenous G protein-coupled receptor 120 (GPR120)/free fatty acid receptor (FFAR) 4 agonist, attenuated the liver inflammation in nonalcoholic steatohepatitis (NASH), while exacerbated liver inflammation was… read more here.
Keywords: inflammation; docosahexaenoic acid; mice; gpr120 ... See more keywords
A peripheral lipid sensor GPR120 remotely contributes to suppression of PGD2-microglia-provoked neuroinflammation and neurodegeneration in the mouse hippocampus
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-021-02361-2
Abstract: Background Neuroinflammation is a key pathological component of neurodegenerative disease and is characterized by microglial activation and the secretion of proinflammatory mediators. We previously reported that a surge in prostaglandin D 2 (PGD 2 )… read more here.
Keywords: gpr120; provoked neuroinflammation; pgd; microglia provoked ... See more keywords
The acute glucose lowering effect of specific GPR120 activation in mice is mainly driven by glucagon-like peptide 1
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0189060
Abstract: The mechanism behind the glucose lowering effect occurring after specific activation of GPR120 is not completely understood. In this study, a potent and selective GPR120 agonist was developed and its pharmacological properties were compared with… read more here.
Keywords: lowering effect; mice; activation; gpr120 ... See more keywords