Indazole-6-phenylcyclopropylcarboxylic Acids as Selective GPR120 Agonists with in Vivo Efficacy.
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DOI: 10.1021/acs.jmedchem.7b00210
Abstract: GPR120 agonists have therapeutic potential for the treatment of diabetes, but few selective agonists have been reported. We identified an indazole-6-phenylcyclopropylcarboxylic acid series of GPR120 agonists and conducted SAR studies to optimize GPR120 potency. Furthermore,… read more here.
Keywords: acids selective; indazole phenylcyclopropylcarboxylic; selective gpr120; gpr120 agonists ... See more keywords
Thiazolidinedione derivatives as novel GPR120 agonists for the treatment of type 2 diabetes
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DOI: 10.1039/d1ra08925k
Abstract: GPR120, also called FFAR4, is preferentially expressed in the intestines, and can be stimulated by long-chain free fatty acids to increase the secretion of glucagon-like peptide-1 (GLP-1) from intestinal endocrine cells. It is known that… read more here.
Keywords: thiazolidinedione derivatives; gpr120 agonists; type diabetes; type ... See more keywords