Imipridone ONC212 activates orphan G protein-coupled receptor GPR132 and integrated stress response in acute myeloid leukemia
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DOI: 10.1038/s41375-019-0491-z
Abstract: Imipridones constitute a novel class of antitumor agents. Here, we report that a second-generation imipridone, ONC212, possesses highly increased antitumor activity compared to the first-generation compound ONC201. In vitro studies using human acute myeloid leukemia… read more here.
Keywords: imipridone onc212; gpr132; integrated stress; stress response ... See more keywords