GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis
Sign Up to like & getrecommendations! Published in 2019 at "Cell"
DOI: 10.1016/j.cell.2019.10.034
Abstract: Although human genetic studies have implicated many susceptible genes associated with plasma lipid levels, their physiological and molecular functions are not fully characterized. Here we demonstrate that orphan G protein-coupled receptor 146 (GPR146) promotes activity… read more here.
Keywords: deficiency protects; cholesterol; gpr146 deficiency; protects hypercholesterolemia ... See more keywords
Generation of a GPR146 knockout human induced pluripotent stem cell line (ITXi001-A-1).
Sign Up to like & getrecommendations! Published in 2022 at "Stem cell research"
DOI: 10.1016/j.scr.2022.102721
Abstract: Dyslipidemia is a key modifiable causal risk factor involved in the development of atherosclerotic cardiovascular disease. Recently, the G protein-coupled receptor 146 (GPR146), a member of the G-coupled protein receptors' family, has been shown to… read more here.
Keywords: gpr146; human induced; stem; pluripotent stem ... See more keywords
GPR146 inhibition protects against atherosclerosis
Sign Up to like & getrecommendations! Published in 2019 at "Nature Reviews Drug Discovery"
DOI: 10.1038/d41573-019-00204-7
Abstract: Human genetic studies have established the orphan G proteincoupled receptor gene, GPR146, as a regulator of plasma cholesterol levels. In line with these findings, Yu et al. report that depletion of GPR146 in mice substantially… read more here.
Keywords: inhibition protects; gpr146 inhibition; atherosclerosis; protects atherosclerosis ... See more keywords
Targeting orphan G protein‐coupled receptors for the treatment of diabetes and its complications: C‐peptide and GPR146
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Internal Medicine"
DOI: 10.1111/joim.12528
Abstract: G protein‐coupled receptors (GPCRs) are the most abundant receptor family encoded by the human genome and are the targets of a high percentage of drugs currently in use or in clinical trials for the treatment… read more here.
Keywords: treatment; protein coupled; coupled receptors; gpr146 ... See more keywords
Variants in the GPR146 Gene Are Associated With a Favorable Cardiometabolic Risk Profile
Sign Up to like & getrecommendations! Published in 2022 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.122.317514
Abstract: Background: In mice, GPR146 (G-protein–coupled receptor 146) deficiency reduces plasma lipids and protects against atherosclerosis. Whether these findings translate to humans is unknown. Methods: Common and rare genetic variants in the GPR146 gene locus were… read more here.
Keywords: variants gpr146; carriers common; risk; gpr146 ... See more keywords