Endocytic proteins mediating GPR15 receptor internalisation provide insight into the underlying mechanisms.
Sign Up to like & getrecommendations! Published in 2023 at "FEBS letters"
DOI: 10.1002/1873-3468.14622
Abstract: GPR15 is a G protein-coupled receptor involved in immune disorders such as human immunodeficiency virus-induced enteropathy, multiple sclerosis, and colitis. Yet, the important endocytosis mechanism of GPR15 remained unclear. This study determined the participation of… read more here.
Keywords: gpr15; proteins mediating; endocytic proteins; internalisation ... See more keywords
Inflammatory biomarker relationships with helper T cell GPR15 expression and cannabis and tobacco smoking.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of psychosomatic research"
DOI: 10.1016/j.jpsychores.2020.110326
Abstract: OBJECTIVE Smoking is associated with numerous inflammatory and autoimmune conditions. The goal of this study was to examine whether increased expression of G-protein-coupled receptor 15 (GPR15) on helper T cells in smokers could predispose to… read more here.
Keywords: cannabis; smoking; helper cells; expression ... See more keywords
PTU-010 Role for GPR15 rather than beta 7 integrins in the pathogenesis of autoimmune liver disease
Sign Up to like & getrecommendations! Published in 2019 at "Gut"
DOI: 10.1136/gutjnl-2019-bsgabstracts.219
Abstract: Introduction G protein-coupled receptor 15 (GPR15) is a chemoattractant receptor that directs homing of lymphocytes to the colon. Furthermore, it has been shown to be a mediator of effector T cell homing during intestinal inflammation.… read more here.
Keywords: gpr15; effector; disease; gut ... See more keywords
Tyrosine sulfation and O-glycosylation of chemoattractant receptor GPR15 differentially regulate interaction with GPR15L.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cell science"
DOI: 10.1242/jcs.247833
Abstract: GPR15 is a G protein-coupled receptor (GPCR) that directs lymphocyte homing to the colon and skin. Recent studies have identified a chemokine-like protein C10orf99/GPR15L as a functional ligand of GPR15. In this study we examined… read more here.
Keywords: gpr15l; sulfation; interaction; receptor ... See more keywords
The G Protein-Coupled Receptor (GPR) 15 Counteracts Antibody-Mediated Skin Inflammation
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.01858
Abstract: The G protein-coupled receptor 15 (GPR15) has recently been highlighted as an important regulator of T cell trafficking into the gut under physiological and pathophysiological conditions. Additionally, circumstantial evidence has accumulated that GPR15 may also… read more here.
Keywords: mediated skin; inflammation; protein coupled; coupled receptor ... See more keywords
Elevated Expression and Activation of GPR15 in Immune Cells in Graves’ Disease
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12121899
Abstract: GPR15 plays an important role in lymphocyte homing and is a key immune molecule to maintain organ immune homeostasis. Yet, no study on the association between GPR15 and Graves’ disease (GD) is available. In this… read more here.
Keywords: gpr15; expression; immune cells; graves disease ... See more keywords