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   Articles with "gpr161" as a keyword



Basal Suppression of the Sonic Hedgehog Pathway by the G-Protein-Coupled Receptor Gpr161 Restricts Medulloblastoma Pathogenesis.

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recommendations! Published in 2018 at "Cell reports"

DOI: 10.1016/j.celrep.2018.01.018

Abstract: Sonic hedgehog (Shh) determines cerebellar granule cell (GC) progenitor proliferation and medulloblastoma pathogenesis. However, the pathways regulating GC progenitors during embryogenesis before Shh production by Purkinje neurons and their roles in tumorigenesis remain unclear. The… read more here.

Keywords: gpr161; protein coupled; pathway; shh ... See more keywords

Primary cilia, AKAPs and constitutive activity at the orphan G protein-coupled receptor GPR161: a tale about a tail.

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recommendations! Published in 2023 at "British journal of pharmacology"

DOI: 10.1111/bph.16053

Abstract: Primary cilia are non-motile antennae-like structures responsible for sensing environmental changes in most mammalian cells. Ciliary signalling is largely mediated by the Sonic Hedgehog (Shh) pathway, which acts as a master regulator of ciliary protein… read more here.

Keywords: orphan protein; receptor; protein coupled; gpr161 ... See more keywords

Requirement of IFT-B–BBSome complex interaction in export of GPR161 from cilia

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recommendations! Published in 2019 at "Biology Open"

DOI: 10.1242/bio.043786

Abstract: ABSTRACT The intraflagellar transport (IFT) machinery, which includes the IFT-A and IFT-B complexes, mediates bidirectional trafficking of ciliary proteins. In addition to these complexes, the BBSome, which is composed of eight subunits that are encoded… read more here.

Keywords: ift bbsome; export; gpr161; interaction ... See more keywords

β-Arrestin mediates the export of ciliary GPR161 but not Smoothened together with the BBSome and IFT machinery.

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recommendations! Published in 2025 at "Journal of cell science"

DOI: 10.1242/jcs.263793

Abstract: Specific G protein-coupled receptors (GPCRs) exist on the ciliary membrane. Hedgehog signaling activation triggers the import of Smoothened into and export of GPR161 from cilia. The BBSome comprising eight Bardet-Biedl syndrome (BBS) proteins mediates GPCR… read more here.

Keywords: ift machinery; arrestin; gpr161; ift ... See more keywords