Basal Suppression of the Sonic Hedgehog Pathway by the G-Protein-Coupled Receptor Gpr161 Restricts Medulloblastoma Pathogenesis.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.01.018
Abstract: Sonic hedgehog (Shh) determines cerebellar granule cell (GC) progenitor proliferation and medulloblastoma pathogenesis. However, the pathways regulating GC progenitors during embryogenesis before Shh production by Purkinje neurons and their roles in tumorigenesis remain unclear. The… read more here.
Keywords: gpr161; protein coupled; pathway; shh ... See more keywords
Primary cilia, AKAPs and constitutive activity at the orphan G protein-coupled receptor GPR161: a tale about a tail.
Sign Up to like & getrecommendations! Published in 2023 at "British journal of pharmacology"
DOI: 10.1111/bph.16053
Abstract: Primary cilia are non-motile antennae-like structures responsible for sensing environmental changes in most mammalian cells. Ciliary signalling is largely mediated by the Sonic Hedgehog (Shh) pathway, which acts as a master regulator of ciliary protein… read more here.
Keywords: orphan protein; receptor; protein coupled; gpr161 ... See more keywords
Requirement of IFT-B–BBSome complex interaction in export of GPR161 from cilia
Sign Up to like & getrecommendations! Published in 2019 at "Biology Open"
DOI: 10.1242/bio.043786
Abstract: ABSTRACT The intraflagellar transport (IFT) machinery, which includes the IFT-A and IFT-B complexes, mediates bidirectional trafficking of ciliary proteins. In addition to these complexes, the BBSome, which is composed of eight subunits that are encoded… read more here.
Keywords: ift bbsome; export; gpr161; interaction ... See more keywords