Analysis of the GPR17 receptor in NG2‐glia under physiological conditions unravels a new subset of oligodendrocyte progenitor cells with distinct functions
Sign Up to like & getrecommendations! Published in 2023 at "Glia"
DOI: 10.1002/glia.24356
Abstract: NG2‐glia comprise a heterogeneous population of cycling cells that give rise to mature, myelinating oligodendrocytes. The mechanisms that regulate the process of differentiation from NG2‐glia into oligodendrocytes are still not fully understood but over the… read more here.
Keywords: gpr17; physiological conditions; gpr17 receptor; ng2 glia ... See more keywords
Structural analysis of human G‐protein‐coupled receptor 17 ligand binding sites
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30388
Abstract: The human G protein coupled membrane receptor (GPR17), the sensor of brain damage, is identified as a biomarker for many neurological diseases. In human brain tissue, GPR17 exist in two isoforms, long and short. While… read more here.
Keywords: ligand binding; gpr17; receptor; binding sites ... See more keywords
Transcriptomic analysis of glioblastoma multiforme providing new insights into GPR17 signaling communication
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2020.1841029
Abstract: Abstract Glioblastoma Multiforme (GBM) is one of the most aggressive malignant tumors in the central nervous system, which arises due to the failure or crosstalk in the signaling networks. GPR17, an orphan G protein-coupled receptor… read more here.
Keywords: analysis; glioblastoma; glioblastoma multiforme; gpr17 ... See more keywords
Insulin-like Growth Factor 1 Promotes Cell Proliferation by Downregulation of G-Protein-Coupled Receptor 17 Expression via PI3K/Akt/FoxO1 Signaling in SK-N-SH Cells
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23031513
Abstract: Insulin-like growth factor 1 (IGF-1) not only regulates neuronal function and development but also is neuroprotective in the setting of acute ischemic stroke. G-protein-coupled receptor 17 (GPR17) expression in brain tissue serves as an indicator… read more here.
Keywords: pi3k; gpr17 expression; expression; gpr17 ... See more keywords