Phosphatidylserine Suppresses T Cells Through GPR174, and Co-Inhibition of Adenosine Receptors and GPR174 Synergistically Enhances Th1 Cytokine Production
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DOI: 10.1093/annonc/mdz451.017
Abstract: Abstract Background Extracellular phosphatidylserine (PS) is a potent modulator of immune responses. In addition to exposure during apoptosis, PS is observed on activated platelets, leukocytes, endothelial cells, tumor cells, and exosomes. While PS exposed during… read more here.
Keywords: gpr174; omeros corporation; stock options; stockholder stock ... See more keywords
GPR174 mRNA Acts as a Novel Prognostic Biomarker for Patients With Sepsis via Regulating the Inflammatory Response
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DOI: 10.3389/fimmu.2021.789141
Abstract: Previous studies indicated that G-protein coupled receptor 174 (GPR174) is involved in the dysregulated immune response of sepsis, however, the clinical value and effects of GPR174 in septic patients are still unknown. This study is… read more here.
Keywords: sepsis; gpr174; biomarker; gpr174 mrna ... See more keywords
Gpr174 Knockout Alleviates DSS-Induced Colitis via Regulating the Immune Function of Dendritic Cells
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DOI: 10.3389/fimmu.2022.841254
Abstract: Background Dysfunction of the immune system would disturb the intestinal homeostasis and lead to inflammatory bowel disease (IBD). Dendritic cells (DCs) help maintain intestinal homeostasis and immediately respond to pathogens or injuries once the mucosa… read more here.
Keywords: gpr174; regulating immune; dss induced; colitis ... See more keywords