Rapid GPR183-mediated recruitment of eosinophils to the lung after Mycobacterium tuberculosis infection
Sign Up to like & getrecommendations! Published in 2022 at "Cell reports"
DOI: 10.1101/2022.02.18.480919
Abstract: Influx of eosinophils into the lungs is typically associated with type-II responses during allergy, fungal and parasitic infections. However, we previously reported that eosinophils accumulate in lung lesions during type-I inflammatory responses to Mycobacterium tuberculosis… read more here.
Keywords: mycobacterium tuberculosis; gpr183; eosinophils lung; mtb ... See more keywords
The oxysterol receptor GPR183 in inflammatory bowel diseases
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15311
Abstract: Immune cell trafficking is an important mechanism for the pathogenesis of inflammatory bowel disease (IBD). The oxysterol receptor GPR183 and its ligands, dihydroxylated oxysterols, can mediate positioning of immune cells including innate lymphoid cells. GPR183… read more here.
Keywords: gpr183; inflammatory bowel; colitis; receptor gpr183 ... See more keywords
Migration mediated by the oxysterol receptor GPR183 depends on arrestin coupling but not receptor internalization
Sign Up to like & getrecommendations! Published in 2023 at "Science Signaling"
DOI: 10.1126/scisignal.abl4283
Abstract: The chemotactic G protein–coupled receptor GPR183 and its most potent endogenous oxysterol ligand 7α,25-dihydroxycholesterol (7α,25-OHC) are important for immune cell positioning in secondary lymphoid tissues. This receptor-ligand pair is associated with various diseases, in some… read more here.
Keywords: ligand induced; internalization; gpr183; receptor internalization ... See more keywords
Oxysterol Sensing Through GPR183 Triggers Endothelial Senescence in Hypertension
Sign Up to like & getrecommendations! Published in 2024 at "Circulation Research"
DOI: 10.1161/circresaha.124.324722
Abstract: BACKGROUND: Despite endothelial dysfunction being an initial step in the development of hypertension and associated cardiovascular/renal injuries, effective therapeutic strategies to prevent endothelial dysfunction are still lacking. GPR183 (G protein-coupled receptor 183), a recently identified… read more here.
Keywords: hypertension; hypertensive mice; gpr183; endothelial senescence ... See more keywords
G Protein-Coupled Receptor 183 Mediates Homoharringtonine Resistance Via NF-Κb Pathway in Acute Myeloid Leukemia
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DOI: 10.1182/blood-2024-204563
Abstract: Background: Homoharringtonine (HHT) is commonly used as a first-line chemotherapy treatment for acute myeloid leukemia (AML) in China. However, drug resistance presents a significant challenge to treatment efficacy. Identifying key genes and elucidating the mechanisms… read more here.
Keywords: hht resistance; gpr183; resistance; aml ... See more keywords
Sexual Dimorphism in the Immunometabolic Role of Gpr183 in Mice
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DOI: 10.1210/jendso/bvae188
Abstract: Abstract Context Excessive eating and intake of a Western diet negatively affect the intestinal immune system, resulting in compromised glucose homeostasis and lower gut bacterial diversity. The G protein–coupled receptor GPR183 regulates immune cell migration… read more here.
Keywords: sexual dimorphism; gpr183; gpr183 mice; immunometabolic role ... See more keywords
GPR183 Regulates Interferons, Autophagy, and Bacterial Growth During Mycobacterium tuberculosis Infection and Is Associated With TB Disease Severity
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.601534
Abstract: Oxidized cholesterols have emerged as important signaling molecules of immune function, but little is known about the role of these oxysterols during mycobacterial infections. We found that expression of the oxysterol-receptor GPR183 was reduced in… read more here.
Keywords: mycobacterium; gpr183; associated disease; infection ... See more keywords