Immunoblot Detection of the Phosphorylation of the Estrogen Receptor α as an Outcome of GPR30 /GPER1 Activation.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1920-9_2
Abstract: Phosphorylation of the serine residues in estrogen receptor (ER) α is important in transcriptional activation. Hence, methods to detect such posttranslational modification events are valuable. We describe, in detail, the analysis of the phosphorylated ERα… read more here.
Keywords: estrogen receptor; gpr30; activation; phosphorylation ... See more keywords
Activation of GPR30 with G1 attenuates neuronal apoptosis via src/EGFR/stat3 signaling pathway after subarachnoid hemorrhage in male rats
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2019.113008
Abstract: BACKGROUND Neuron apoptosis plays a vital role in early brain injury (EBI) after subarachnoid hemorrhage (SAH). Previous studies showed that the activation of G protein-coupled receptor 30 (GPR30) with GPR30 agonist G1 was anti-apoptotic after… read more here.
Keywords: male rats; apoptosis; gpr30; egfr stat3 ... See more keywords
Localization of estrogen receptor ERα, ERβ and GPR30 on myenteric neurons of the gastrointestinal tract and their role in motility.
Sign Up to like & getrecommendations! Published in 2019 at "General and comparative endocrinology"
DOI: 10.1016/j.ygcen.2018.11.016
Abstract: Estrogen is well known to have a modulatory role on gastrointestinal tract, particularly through its interaction with nuclear estrogen receptors (ERs), alpha and beta (ERα/β). Recent functional studies also indicate that estrogen can activate a… read more here.
Keywords: gastrointestinal tract; receptor gpr30; gpr30; estrogen ... See more keywords
Cisplatin resistance in gastric cancer cells is involved with GPR30‐mediated epithelial‐mesenchymal transition
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.15055
Abstract: Cisplatin is the major chemotherapeutic drug in gastric cancer, particularly in treating advanced gastric cancer. Tumour cells often develop resistance to chemotherapeutic drugs, which seriously affects the efficacy of chemotherapy. GPR30 is a novel oestrogen… read more here.
Keywords: gastric cancer; gpr30; cisplatin; resistance ... See more keywords
Two gallstone (Lith) genes, Lith9 and Lith18, produces a synergistic effect in enhancing cholelithogenesis by promoting hepatic secretion of biliary cholesterol in female mice
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5730554
Abstract: Estrogen is a critical risk factor for cholesterol gallstone disease because women are twice as likely as men to form gallstones. We have identified that the G protein-coupled receptor 30 (GPR30), a new estrogen receptor,… read more here.
Keywords: gallstone; physiology; mice; cholesterol ... See more keywords
GPR30 Activation Promotes the Progression of Gastric Cancer and Plays a Significant Role in the Anti-GC Effect of Huaier
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Oncology"
DOI: 10.1155/2022/2410530
Abstract: Gastric cancer (GC) is one of the most common types of cancer. The n-butanol extract of Huaier (NEH) is the alcohol-soluble part extracted by the systematic solvent method, which is effective against gastric cancer (GC).… read more here.
Keywords: cancer; expression; anti effect; gpr30 ... See more keywords
The Expression of GPR30 in Iron-Overloaded Atypical Ovarian Epithelium and Ectopic Endometrium Is Closely Correlated with Transferrin Receptor and Pi3K
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DOI: 10.1155/2022/8338874
Abstract: Background The mechanism of atypical hyperplasia of the ovarian epithelium and ectopic endometrium caused by iron overload remains unclear. Accordingly, we investigated possible effects on the human ovarian ectopic endometrium and ovarian epithelium by producing… read more here.
Keywords: endometrium; pi3k; iron; gpr30 ... See more keywords
Plasma membrane expression of G protein-coupled estrogen receptor (GPER)/G protein-coupled receptor 30 (GPR30) is associated with worse outcome in metachronous contralateral breast cancer
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DOI: 10.1371/journal.pone.0231786
Abstract: Background G protein-coupled estrogen receptor (GPER), or G protein-coupled receptor 30 (GPR30), is reported to mediate non-genomic estrogen signaling. GPR30 associates with breast cancer (BC) outcome and may contribute to tamoxifen resistance. We investigated the… read more here.
Keywords: bc2; gpr30; protein coupled; expression ... See more keywords
Interaction Between CCL18 and GPR30 Differs from the Interaction Between Estradiol and GPR30
Sign Up to like & getrecommendations! Published in 2020 at "AntiCancer Research"
DOI: 10.21873/anticanres.14291
Abstract: Background/Aim: C-C motif chemokine ligand 18 (CCL18) is overexpressed in the microenvironment of tumors, promotes invasion and metastasis and is thus important for the therapeutic outcome of many tumor entities. The Gs-coupled seven-transmembrane receptor GPR30… read more here.
Keywords: stimulation; gpr30; signaling pathway; expression ... See more keywords
Downregulation of G-protein-coupled receptor 30 in the hippocampus attenuates the neuroprotection of estrogen in the critical period hypothesis
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2018.8618
Abstract: The aim of the present study was to investigate the role of G-protein-coupled receptor 30 (GPR30) in long-term 17β-estradiol (E2) deprivation (LTED) in a rat model with global cerebral ischemia (GCI), and its therapeutic target… read more here.
Keywords: protein; gpr30; protein coupled; coupled receptor ... See more keywords