LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "gpr39" as a keyword



Photo by dnevozhai from unsplash

An agonist of a zinc‐sensing receptor GPR39 enhances tight junction assembly in intestinal epithelial cells via an AMPK‐dependent mechanism

Sign Up to like & get
recommendations! Published in 2019 at "European Journal of Pharmacology"

DOI: 10.1016/j.ejphar.2018.10.038

Abstract: Abstract Intestinal barrier function depends on integrity of tight junctions, which serve as barriers to transepithelial influx of noxious substances/microorganisms from gut lumen. The G‐protein coupled receptor 39 (GPR39) is a zinc‐sensing receptor, which is… read more here.

Keywords: zinc; gpr39; junction assembly; receptor ... See more keywords
Photo by a2eorigins from unsplash

Obestatin ameliorates water retention in chronic heart failure by downregulating renal aquaporin 2 through GPR39, V2R and PPARG signaling.

Sign Up to like & get
recommendations! Published in 2019 at "Life sciences"

DOI: 10.1016/j.lfs.2019.05.049

Abstract: AIMS Obestatin regulates water metabolism by inhibiting arginine vasopressin (AVP) release and upregulated obestatin has been detected in patients with chronic heart failure (CHF). However, the significance of obestatin in CHF, particularly with regard to… read more here.

Keywords: water retention; v2r; pparg; water ... See more keywords
Photo by foodistika from unsplash

Inhibition of GPR39 restores defects in endothelial cell–mediated neovascularization under the duress of chronic hyperglycemia: Evidence for regulatory roles of the sonic hedgehog signaling axis

Sign Up to like & get
recommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2208541120

Abstract: Significance GPR39 is an orphan GPR whose physiological ligand and intracellular pathways in ECs remain poorly characterized. Our data indicate that inhibition of GPR39 protects EC functions by enhancing SHH signaling in aortic ECs. Understanding… read more here.

Keywords: gpr39; hyperglycemia; inhibition gpr39; restores defects ... See more keywords
Photo from wikipedia

Uncovering the functional role of GPR39 in the renal collecting duct

Sign Up to like & get
recommendations! Published in 2023 at "Physiology"

DOI: 10.1152/physiol.2023.38.s1.5794821

Abstract: G protein-coupled receptors (GPCRs) are seven transmembrane domain receptors that comprise the largest class of proteins in the mammalian genome. GPR39 is part of the ghrelin subfamily of GPCRs, and is well-expressed in the kidney… read more here.

Keywords: collecting duct; expression; physiology; gpr39 ... See more keywords

GPR39 Overexpression in OSCC Promotes YAP-Sustained Malignant Progression

Sign Up to like & get
recommendations! Published in 2020 at "Journal of Dental Research"

DOI: 10.1177/0022034520915877

Abstract: The clinical outcome of oral squamous cell carcinoma (OSCC) has not improved in recent years, mainly due to the limited effective targeted therapy that has been applied. Recently, a transcriptional coactivator, YAP, has been shown… read more here.

Keywords: gpr39; malignant progression; yap sustained; progression ... See more keywords
Photo by nci from unsplash

Activation of the Zinc-sensing receptor GPR39 promotes T cell reconstitution after hematopoietic cell transplant in mice.

Sign Up to like & get
recommendations! Published in 2022 at "Blood"

DOI: 10.1182/blood.2021013950

Abstract: Prolonged lymphopenia represents a major clinical problem after cytoreductive therapies such as chemotherapy and the conditioning required for hematopoietic stem cell transplant (HSCT), contributing toward the risk of infections and malignant relapse. Restoration of T… read more here.

Keywords: gpr39; cell transplant; hsct; receptor gpr39 ... See more keywords

The Zinc-sensing Receptor (GPR39) Modulates Declarative Memory and Age-related Hippocampal Gene Expression in Male Mice

Sign Up to like & get
recommendations! Published in 2022 at "Neuroscience"

DOI: 10.2139/ssrn.4071678

Abstract: As a neuromodulator, zinc regulates synaptic plasticity, learning and memory. Synaptic zinc is also a crucial factor in the development of toxic forms of amyloid beta protein and, subsequently, of Alzheimer's dementia (AD). Therefore, efforts… read more here.

Keywords: zinc sensing; age; gpr39; mice ... See more keywords
Photo from wikipedia

Functions of the Zinc-Sensing Receptor GPR39 in Regulating Intestinal Health in Animals

Sign Up to like & get
recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms232012133

Abstract: G protein-coupled receptor 39 (GPR39) is a zinc-sensing receptor (ZnR) that can sense changes in extracellular Zn2+, mediate Zn2+ signal transmission, and participate in the regulation of numerous physiological activities in living organisms. For example,… read more here.

Keywords: health; receptor gpr39; intestinal health; zinc sensing ... See more keywords