Orphan receptor GPR50 attenuates inflammation and insulin signaling in 3T3‐L1 preadipocytes
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DOI: 10.1002/2211-5463.13516
Abstract: Type 2 diabetes (T2DM) is characterized by insulin secretion deficiencies and systemic insulin resistance (IR) in adipose tissue, skeletal muscle, and the liver. Although the mechanism of T2DM is not yet fully known, inflammation and… read more here.
Keywords: 3t3 preadipocytes; insulin signaling; receptor; gpr50 ... See more keywords
Orphan GPR50 Restrains Neurite Outgrowth and Cell Migration by Activating the G12/13 Protein‐RhoA Pathway in Neural Progenitor Cells and Tanycytes
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DOI: 10.1111/jpi.70041
Abstract: Human genetic variants of the orphan G protein‐coupled receptor GPR50 are suggested risk factors for neuropsychiatric disorders. However, the function of GPR50 in the central nervous system (CNS) and its link to CNS disorders remain… read more here.
Keywords: g12 protein; protein rhoa; protein; cell ... See more keywords
The Orphan GPR50 Receptor Regulates the Aggressiveness of Breast Cancer Stem-like Cells via Targeting the NF-kB Signaling Pathway
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DOI: 10.3390/ijms24032804
Abstract: The expression of GPR50 in CSLC and several breast cancer cell lines was assessed by RT-PCR and online platform (UALCAN, GEPIA, and R2 gene analysis). The role of GPR50 in driving CSLC, sphere formation, cell… read more here.
Keywords: cancer stem; stem like; breast cancer; like cells ... See more keywords