Presynaptic nigral GPR55 receptors stimulate [3H]‐GABA release through [3H]‐cAMP production and PKA activation and promote motor behavior
Sign Up to like & getrecommendations! Published in 2022 at "Synapse"
DOI: 10.1002/syn.22246
Abstract: Striatal medium‐sized spiny neurons express mRNA and protein of GPR55 receptors that stimulate neurotransmitter release; thus, GPR55 could be sent to nigral striatal projections, where it might modulate GABA release and motor behavior. Here, we… read more here.
Keywords: gaba release; receptors stimulate; gpr55; gpr55 receptors ... See more keywords
Expression of GPR55 and either cannabinoid CB1 or CB2 heteroreceptor complexes in the caudate, putamen, and accumbens nuclei of control, parkinsonian, and dyskinetic non-human primates
Sign Up to like & getrecommendations! Published in 2020 at "Brain Structure and Function"
DOI: 10.1007/s00429-020-02116-4
Abstract: Endocannabinoids are neuromodulators acting on specific cannabinoid CB1 and CB2 G-protein-coupled receptors (GPCRs), representing potential therapeutic targets for neurodegenerative diseases. Cannabinoids also regulate the activity of GPR55, a recently “deorphanized” GPCR that directly interacts with… read more here.
Keywords: gpr55; control; expression; cb2 ... See more keywords
Alterations in Gene and Protein Expression of Cannabinoid CB2 and GPR55 Receptors in the Dorsolateral Prefrontal Cortex of Suicide Victims
Sign Up to like & getrecommendations! Published in 2018 at "Neurotherapeutics"
DOI: 10.1007/s13311-018-0610-y
Abstract: Recent studies point to the cannabinoid CB2 receptors (CB2r) and the non-cannabinoid receptor GPR55 as potential key targets involved in the response to stress, anxiety, and depression. Considering the close relationship between neuropsychiatric disorders and… read more here.
Keywords: protein expression; gpr55; suicide; suicide victims ... See more keywords
Activation of GPR55 induces neuroprotection of hippocampal neurogenesis and immune responses of neural stem cells following chronic, systemic inflammation
Sign Up to like & getrecommendations! Published in 2019 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2018.11.017
Abstract: New neurons are continuously produced by neural stem cells (NSCs) within the adult hippocampus. Numerous diseases, including major depressive disorder and HIV-1 associated neurocognitive disorder, are associated with decreased rates of adult neurogenesis. A hallmark… read more here.
Keywords: gpr55; neurogenesis; inflammation; activation ... See more keywords
N-arachidonoyl glycine, another endogenous agonist of GPR55.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.07.038
Abstract: Interest in lipoamino acids as endogenous modulators of G-protein coupled receptors has escalated due to their involvement in a variety of physiologic processes. In particular, a role for these amino acid conjugates has emerged in… read more here.
Keywords: gpr55; another endogenous; endogenous agonist; agonist gpr55 ... See more keywords
GPR55: A therapeutic target for Parkinson's disease?
Sign Up to like & getrecommendations! Published in 2017 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2017.08.017
Abstract: The GPR55 receptor is expressed abundantly in the brain, especially in the striatum, suggesting it might fulfill a role in motor function. Indeed, motor behavior is impaired in mice lacking GPR55, which also display dampened… read more here.
Keywords: gpr55; abn cbd; cbd; parkinson disease ... See more keywords
Activation of GPR55 attenuates cognitive impairment and neurotoxicity in a mouse model of Alzheimer's disease induced by Aβ1–42 through inhibiting RhoA/ROCK2 pathway
Sign Up to like & getrecommendations! Published in 2021 at "Progress in Neuro-Psychopharmacology and Biological Psychiatry"
DOI: 10.1016/j.pnpbp.2021.110423
Abstract: The accumulation of amyloid-β (Aβ) peptides in the brain is considered to be the initial event in the Alzheimer's disease (AD). Neurotoxicity mediated by Aβ has been demonstrated to damage the cognitive function. In the… read more here.
Keywords: gpr55; cognitive impairment; impairment; rhoa rock2 ... See more keywords
Heterozygous deletion of Gpr55 does not affect a hyperthermia-induced seizure, spontaneous seizures or survival in the Scn1a+/- mouse model of Dravet syndrome
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0280842
Abstract: A purified preparation of cannabidiol (CBD), a cannabis constituent, has been approved for the treatment of intractable childhood epilepsies such as Dravet syndrome. Extensive pharmacological characterization of CBD shows activity at numerous molecular targets but… read more here.
Keywords: seizure; scn1a mice; deletion; gpr55 ... See more keywords
Role of Major Endocannabinoid-Binding Receptors during Mouse Oocyte Maturation
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20122866
Abstract: Endocannabinoids are key-players of female fertility and potential biomarkers of reproductive dysfunctions. Here, we investigated localization and expression of cannabinoid receptor type-1 and -2 (CB1R and CB2R), G-protein coupled receptor 55 (GPR55), and transient receptor… read more here.
Keywords: cb1r; gpr55; cb2r gpr55; cb1r cb2r ... See more keywords
Lysophosphatidylinositol Induced Morphological Changes and Stress Fiber Formation through the GPR55-RhoA-ROCK Pathway
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231810932
Abstract: We previously reported that lysophosphatidylinositol (LPI) functions as an endogenous agonist of GPR55, a novel cannabinoid receptor. However, the physiological roles of LPI-GPR55 have not yet been elucidated in detail. In the present study, we… read more here.
Keywords: morphological changes; rock; induced morphological; gpr55 ... See more keywords
Lysophosphatidylinositol Promotes Chemotaxis and Cytokine Synthesis in Mast Cells with Differential Participation of GPR55 and CB2 Receptors
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24076316
Abstract: Mast cells (MCs) are the main participants in the control of immune reactions associated with inflammation, allergies, defense against pathogens, and tumor growth. Bioactive lipids are lipophilic compounds able to modulate MC activation. Here, we… read more here.
Keywords: participation gpr55; gpr55; mast cells; gpr55 cb2 ... See more keywords