GPR56 S4 variant is required for microglia‐mediated synaptic pruning
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24293
Abstract: ADGRG1 (also called GPR56) plays critical roles in brain development and wiring, including cortical lamination, central nervous system (CNS) myelination, and developmental synaptic refinement. However, the underlying mechanism(s) in mediating such diverse functions is not… read more here.
Keywords: synaptic pruning; microglia mediated; gpr56 variant; mediated synaptic ... See more keywords
57R2A, a newly established monoclonal antibody against mouse GPR56, marks long-term repopulating hematopoietic stem cells.
Sign Up to like & getrecommendations! Published in 2018 at "Experimental hematology"
DOI: 10.1016/j.exphem.2017.12.001
Abstract: GPR56 molecule, a G-protein-coupled receptor, was suggested to be expressed in mouse hematopoietic stem cells (HSCs) by gene expression analyses. However, little is known about the cell surface expression of GPR56 protein in mouse HSCs… read more here.
Keywords: protein; gpr56; hematopoietic stem; stem cells ... See more keywords
Cytotoxic T Lymphocytes Expressing GPR56 are Up-regulated in the Peripheral Blood of Patients with Active Rheumatoid Arthritis and Reflect Disease Progression
Sign Up to like & getrecommendations! Published in 2022 at "Immunological Investigations"
DOI: 10.1080/08820139.2022.2058403
Abstract: ABSTRACT Objective This study aims to elucidate the changes in the percentage of GPR56 and/or granzyme B (GZMB) positive cells in rheumatoid arthritis (RA) CD4 and CD8 T lymphocytes, and to explore their clinical value… read more here.
Keywords: gpr56 gzmb; gzmb cells; patients active; arthritis ... See more keywords
Microglial GPR56 is the molecular target of maternal immune activation-induced parvalbumin-positive interneuron deficits.
Sign Up to like & getrecommendations! Published in 2022 at "Science advances"
DOI: 10.1126/sciadv.abm2545
Abstract: Parvalbumin-positive (PV+) interneurons play a critical role in maintaining circuit rhythm in the brain, and their reduction is implicated in autism spectrum disorders. Animal studies demonstrate that maternal immune activation (MIA) leads to reduced PV+… read more here.
Keywords: parvalbumin positive; microglial gpr56; maternal immune; interneuron ... See more keywords
Bi-allelic variants in COL3A1 encoding the ligand to GPR56 are associated with cobblestone-like cortical malformation, white matter changes and cerebellar cysts
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Medical Genetics"
DOI: 10.1136/jmedgenet-2016-104421
Abstract: Background Collagens are one of the major constituents of the pial membrane, which plays a crucial role in neuronal migration and cortical lamination during brain development. Type III procollagen, the chains of which are encoded… read more here.
Keywords: gpr56; cobblestone; malformation white; cobblestone like ... See more keywords
Ablation of GPR56 Causes β-Cell Dysfunction by ATP Loss through Mistargeting of Mitochondrial VDAC1 to the Plasma Membrane
Sign Up to like & getrecommendations! Published in 2023 at "Biomolecules"
DOI: 10.3390/biom13030557
Abstract: The activation of G Protein-Coupled Receptor 56 (GPR56), also referred to as Adhesion G-Protein-Coupled Ceceptor G1 (ADGRG1), by Collagen Type III (Coll III) prompts cell growth, proliferation, and survival, among other attributes. We investigated the… read more here.
Keywords: cell; vdac1; gpr56; atp loss ... See more keywords
Transcriptomics and Phenotypic Analysis of gpr56 Knockout in Zebrafish
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24097740
Abstract: The adhesion G-protein-coupled receptor is a seven-transmembrane receptor protein with a complex structure. Impaired GPR56 has been found to cause developmental damage to the human brain, resulting in intellectual disability and motor dysfunction. To date,… read more here.
Keywords: transcriptomics phenotypic; phenotypic analysis; gpr56 knockout; knockout zebrafish ... See more keywords