GPR68 Improves Nerve Damage and Myelination in an Immature Rat Model Induced by Sevoflurane Anesthesia by Activating cAMP/CREB to Mediate BDNF.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.1c00830
Abstract: Ovarian cancer G-protein-coupled receptor 1 (OGR1, also known as GPR68) is a member of proton-sensing G-protein-coupled receptors, involved in cardiovascular physiology, tumor biology, and asthma, and exerts a neuroprotective effect against brain ischemia. The effects… read more here.
Keywords: damage myelination; nerve damage; gpr68; sevoflurane induced ... See more keywords
Abstract 443: Therapeutic targeting of GPR68 activated by acidic extracellular microenvironment induces ferroptosis in glioblastoma cells
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-443
Abstract: The Warburg Effect is a common feature of cancer cells characterized by increased glucose uptake and fermentation of glucose to lactate even in the presence of oxygen. While it is commonly accepted that Warburg Effect… read more here.
Keywords: glioblastoma cells; glioblastoma; microenvironment; warburg effect ... See more keywords
Abstract 444: Inhibition of GPR68 signaling activated downstream of the Warburg effect induces cell death and enhances radiosensitivity in diverse cancer cell types
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-444
Abstract: Introduction: The Warburg effect, a phenomenon in which cancer cells produce energy via aerobic glycolysis, is a hallmark of cancer. A key physiological consequence of the Warburg effect is lactate secretion, which acidifies the tumor… read more here.
Keywords: cell; inhibition; effect; warburg effect ... See more keywords
Expression of GPR68, an Acid-Sensing Orphan G Protein-Coupled Receptor, in Breast Cancer
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DOI: 10.3389/fonc.2022.847543
Abstract: Background Breast cancer (BC) is the most diagnosed cancer and the leading cause of global cancer incidence in 2020. It is quite known that highly invasive cancers have disrupted metabolism that leads to the creation… read more here.
Keywords: expression gpr68; expression; gpr68; breast cancer ... See more keywords