Effect of GPR84 deletion on obesity and diabetes development in mice fed long chain or medium chain fatty acid rich diets
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Nutrition"
DOI: 10.1007/s00394-017-1456-5
Abstract: PurposeAlthough there is good evidence showing that diets rich in medium chain fatty acids (MCFAs) have less marked obesogenic and diabetogenic effects than diets rich in long chain fatty acids (LCFAs), the role of the… read more here.
Keywords: chain; medium chain; gpr84; mice fed ... See more keywords
Discovery of 9-cyclopropylethynyl-2-((S)-1-[1,4]dioxan-2-ylmethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one (GLPG1205), a Unique GPR84 Negative Allosteric Modulator Undergoing Evaluation in a Phase II Clinical Trial.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c00272
Abstract: GPR84 is a medium chain free fatty acid-binding G protein-coupled receptor associated with inflammatory and fibrotic diseases. As the only reported antagonist of GPR84 (PBI-4050) displays relatively low potency and selectivity, a clear need exists… read more here.
Keywords: discovery cyclopropylethynyl; glpg1205; gpr84; modulator ... See more keywords
Investigating the Structure–Activity Relationship of 1,2,4-Triazine G-Protein-Coupled Receptor 84 (GPR84) Antagonists
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.2c00804
Abstract: G-protein-coupled receptor 84 (GPR84) is a proinflammatory orphan G-protein-coupled receptor implicated in several inflammatory and fibrotic diseases. Several agonist and antagonist ligands have been developed that target GPR84; however, a noncompetitive receptor blocker that was… read more here.
Keywords: receptor gpr84; gpr84; coupled receptor; receptor ... See more keywords
A biased agonist at immunometabolic receptor GPR84 causes distinct functional effects in macrophages.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical biology"
DOI: 10.1021/acschembio.9b00533
Abstract: GPR84 is an orphan G protein-coupled receptor which is expressed on immune cells and implicated in several inflammatory diseases. The validation of GPR84 as a therapeutic target is hindered by the narrow range of available… read more here.
Keywords: biased agonist; agonist immunometabolic; receptor gpr84; gpr84 ... See more keywords
Function and regulation of GPR84 in human neutrophils.
Sign Up to like & getrecommendations! Published in 2023 at "British journal of pharmacology"
DOI: 10.1111/bph.16066
Abstract: Human neutrophils belong to the innate immune system and are the most abundant white blood cells in circulation. They are professional phagocytes and express several G protein-coupled receptors (GPCRs) which are essential for proper neutrophil… read more here.
Keywords: gpr84; human neutrophils; pharmacology; regulation gpr84 ... See more keywords
Activation of the Immune-Metabolic Receptor GPR84 Enhances Inflammation and Phagocytosis in Macrophages
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.01419
Abstract: GPR84 is a member of the metabolic G protein-coupled receptor family, and its expression has been described predominantly in immune cells. GPR84 activation is involved in the inflammatory response, but the mechanisms by which it… read more here.
Keywords: phagocytosis macrophages; inflammation; gpr84; expression ... See more keywords