Orphan Receptor GPR88 as an Emerging Neurotherapeutic Target.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.8b00572
Abstract: Although G protein-coupled receptors (GPCRs) are recognized as pivotal drug targets involved in multiple physiological and pathological processes, the majority of GPCRs including orphan GPCRs (oGPCRs) are unexploited. GPR88, a brain-specific oGPCR with particularly robust… read more here.
Keywords: gpr88; orphan receptor; target; neurotherapeutic target ... See more keywords
Development and validation of a high-throughput calcium mobilization assay for the orphan receptor GPR88
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Biomedical Science"
DOI: 10.1186/s12929-017-0330-3
Abstract: BackgroundGPR88 is an orphan G protein-coupled receptor highly expressed in the striatum and is implicated in basal ganglia-associated disorders. However, the receptor functions of GPR88 are still largely unknown due to the lack of potent… read more here.
Keywords: gpr88; calcium mobilization; mobilization assay; calcium ... See more keywords
GPR88 in D1R-Type and D2R-Type Medium Spiny Neurons Differentially Regulates Affective and Motor Behavior
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DOI: 10.1523/eneuro.0035-19.2019
Abstract: Visual Abstract The orphan receptor GPR88 is highly expressed in D1 receptor (D1R)- and D2R-medium spiny neurons (MSNs) and has been associated to striatum-dependent functions in rodents. The total deletion of Gpr88 in mice was… read more here.
Keywords: d2r; gpr88; d1r; motor ... See more keywords