Soluble CLEC-2 is generated independently of ADAM10 and is increased in plasma in acute coronary syndrome: comparison with soluble GPVI
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Hematology"
DOI: 10.1007/s12185-019-02680-4
Abstract: Soluble forms of platelet membrane proteins are released upon platelet activation. We previously reported that soluble C-type lectin-like receptor 2 (sCLEC-2) is released as a shed fragment (Shed CLEC-2) or as a whole molecule associated… read more here.
Keywords: clec; increased plasma; acute coronary; coronary syndrome ... See more keywords
The Subtilisin-Like Protease Furin Regulates Hemin-Dependent Ectodomain Shedding of Glycoprotein VI
Sign Up to like & getrecommendations! Published in 2022 at "Thrombosis and Haemostasis"
DOI: 10.1055/s-0043-1768057
Abstract: INTRODUCTION Hemolysis results in release of free hemoglobin and hemin liberation from erythrocytes. Hemin has been described to induce platelet activation and to trigger thrombosis. METHODS We evaluated the effect of hemin on platelet function… read more here.
Keywords: hemin dependent; gpvi; furin; hemin induced ... See more keywords
Anti-GPVI (HY101) activates platelets in a multicolor flow cytometry panel
Sign Up to like & getrecommendations! Published in 2022 at "Platelets"
DOI: 10.1080/09537104.2022.2027359
Abstract: Abstract The platelet transmembrane receptor GPVI can be assessed together with other platelet membrane markers in a whole blood multicolor flow cytometry panel. The advantage of combining multiple antibodies in a single tube is the… read more here.
Keywords: gpvi; anti gpvi; cytometry panel; flow cytometry ... See more keywords
GPVI inhibition by glenzocimab synergistically inhibits atherosclerotic plaque-induced platelet activation when combined with conventional dual antiplatelet therapy
Sign Up to like & getrecommendations! Published in 2021 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehab724.1425
Abstract: Aspirin and a potent platelet P2Y12 inhibitor, such as prasugrel or ticagrelor, are not always sufficient to prevent thrombus formation in patients with ST-elevation MI (STEMI), leading to “slow flow” or “no reflow” effects after… read more here.
Keywords: glenzocimab; aspirin ticagrelor; gpvi; atherosclerotic plaque ... See more keywords
Platelet Storage Temperature Determines Recovery of GPVI-Function In Vivo
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood-2020-141741
Abstract: Background: Platelets (PLTs) are currently stored at 22°C (RT, room temperature) for clinical purposes. This approach ensures long circulation time but has numerous downsides, including limited storage time due to the risk of bacterial growth… read more here.
Keywords: storage; stored plts; response; function ... See more keywords
Structural characterisation of a novel GPVI nanobody-complex reveals a biologically active domain-swapped GPVI dimer.
Sign Up to like & getrecommendations! Published in 2021 at "Blood"
DOI: 10.1182/blood.2020009440
Abstract: GPVI is the major signalling receptor for collagen on platelets. We have raised 54 nanobodies (Nb), grouped into 33 structural classes based on their complementary determining region 3 (CDR3) loops, against recombinant GPVI-Fc (dimeric GPVI)… read more here.
Keywords: collagen; domain swapped; domain swap; recombinant gpvi ... See more keywords
Procoagulant platelet sentinels prevent inflammatory bleeding through GPIIBIIIA and GPVI
Sign Up to like & getrecommendations! Published in 2022 at "Blood"
DOI: 10.1182/blood.2021014914
Abstract: Kaiser et al investigated how platelets contribute to vascular integrity during inflammation. They show that single migrating platelets become procoagulant, recruiting the coagulation cascade to prevent pulmonary inflammatory bleeding. This protective action is triggered by… read more here.
Keywords: gpvi; platelet sentinels; procoagulant platelet; sentinels prevent ... See more keywords
Perspective: Collagen induced platelet activation via the GPVI receptor as a primary target of colchicine in cardiovascular disease
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.1104744
Abstract: Colchicine has been demonstrated to reduce cardiovascular death, myocardial infarction (MI), ischemic stroke, and ischemia-driven coronary revascularization in people with coronary artery disease (CAD). These reductions were observed even in patients already taking antiplatelet therapy.… read more here.
Keywords: gpvi; collagen induced; platelet activation; induced platelet ... See more keywords
Minimal Collagen-Binding Epitope of Glycoprotein VI in Human and Mouse Platelets
Sign Up to like & getrecommendations! Published in 2023 at "Biomedicines"
DOI: 10.3390/biomedicines11020423
Abstract: Glycoprotein VI (GPVI) is a platelet-specific receptor for collagen and fibrin, regulating important platelet functions such as platelet adhesion and thrombus growth. Although the blockade of GPVI function is widely recognized as a potent anti-thrombotic… read more here.
Keywords: gpvi; collagen; binding epitope; collagen binding ... See more keywords
The Platelet Collagen Receptor GPVI Is Cleaved by Tspan15/ADAM10 and Tspan33/ADAM10 Molecular Scissors
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23052440
Abstract: The platelet-activating collagen receptor GPVI represents the focus of clinical trials as an antiplatelet target for arterial thrombosis, and soluble GPVI is a plasma biomarker for several human diseases. A disintegrin and metalloproteinase 10 (ADAM10)… read more here.
Keywords: gpvi; cleavage; receptor gpvi; tspan33 ... See more keywords