Targeting platelet GPVI with glenzocimab: a novel mechanism for inhibition
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DOI: 10.1182/bloodadvances.2022007863
Abstract: Key Points • Crystallization studies map the binding of glenzocimab to the site of dimerization in the D2 domain of GPVI.• Glenzocimab inhibits GPVI interactions with CRP, collagen, and fibrin by loss of dimerization, conformational… read more here.
Keywords: glenzocimab novel; glenzocimab; gpvi glenzocimab; platelet gpvi ... See more keywords