The ALA5/ALA6/ALA7 repeat polymorphisms of the glutathione peroxidase‐1 ( GPx1 ) gene and autism spectrum disorder
Sign Up to like & getrecommendations! Published in 2022 at "Autism Research"
DOI: 10.1002/aur.2655
Abstract: Autism is a severe neurodevelopmental disorder leading to deficits in social interaction, communication, and several activities. An increasing number of evidence suggests a role of oxidative stress in the etiology of autism spectrum disorder (ASD).… read more here.
Keywords: autism; autism spectrum; spectrum disorder; gpx1 gene ... See more keywords
Role of glutathione peroxidase 1 in glucose and lipid metabolism‐related diseases
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.05.077
Abstract: ABSTRACT Glutathione peroxidase 1 (GPX1) is a selenium‐dependent enzyme that reduces intracellular hydrogen peroxide and lipid peroxides. While past research explored regulations of gene expression and biochemical function of this selenoperoxidase, GPX1 has recently been… read more here.
Keywords: metabolism related; glutathione peroxidase; gpx1; biology ... See more keywords
Hypothermia Treatment After Hypoxia-Ischemia in Glutathione Peroxidase-1 Overexpressing Mice.
Sign Up to like & getrecommendations! Published in 2023 at "Developmental neuroscience"
DOI: 10.1159/000531204
Abstract: The developing brain is uniquely susceptible to oxidative stress and endogenous antioxidant mechanisms are not sufficient to prevent injury from a hypoxic-ischemic challenge. Glutathione peroxidase (GPX1) activity reduces hypoxic-ischemic injury. Therapeutic hypothermia also reduces hypoxic-ischemic… read more here.
Keywords: hypothermia; glutathione peroxidase; hypoxia ischemia; gpx1 ... See more keywords
Glutathione Peroxidase 1 Protects Against Peroxynitrite-Induced Spiral Ganglion Neuron Damage Through Attenuating NF-κB Pathway Activation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.841731
Abstract: Glutathione peroxidase 1 (GPX1) is a crucial antioxidant enzyme that prevented the harmful accumulation of intra-cellular hydrogen peroxide. GPX1 might contribute in limiting cochlear damages associated with aging or acoustic overexposure, but the function of… read more here.
Keywords: damage; peroxynitrite gpx1; group; spiral ganglion ... See more keywords
Variability in oxidative stress-related genes (SOD2, CAT, GPX1, GSTP1, NOS3, NFE2L2, and UCP2) and susceptibility to migraine clinical phenotypes and features
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2022.1054333
Abstract: Introduction Migraine is a complex disorder with genetic and environmental inputs. Cumulative evidence implicates oxidative stress (OS) in migraine pathophysiology while genetic variability may influence an individuals' oxidative/antioxidant capacity. Aim of the current study was… read more here.
Keywords: gstp1; migraine; oxidative stress; susceptibility ... See more keywords
GPX1 Localizes to the Nucleus in Prostate Epithelium and its Levels are not Associated with Prostate Cancer Recurrence
Sign Up to like & getrecommendations! Published in 2018 at "Antioxidants"
DOI: 10.3390/antiox7110167
Abstract: Glutathione peroxidase 1 (GPX1) is an extensively studied selenium-dependent protein that reduces hydrogen and lipid peroxides to water. Because of its antioxidant function and its responsiveness to dietary intakes of selenium, an essential trace element… read more here.
Keywords: prostate; gpx1; prostate cancer; cancer recurrence ... See more keywords
Glutathione Peroxidase GPX1 and Its Dichotomous Roles in Cancer
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DOI: 10.3390/cancers14102560
Abstract: Simple Summary Glutathione peroxidase 1 (GPX1), as one of the most important antioxidant enzymes, maintains cellular redox balance by regulating reactive oxygen species levels. In this review, we summarize and discuss the relationship between GPX1… read more here.
Keywords: dichotomous roles; glutathione peroxidase; gpx1; cancer ... See more keywords
GABPA protects against gastric cancer deterioration via negatively regulating GPX1
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Biochemistry"
DOI: 10.5937/jomb0-35445
Abstract: Background To explore the anti-cancer role of GABPA in the progression of gastric cancer (GC), and the underlying mechanism. Methods Quantitative real-time polymerase chain reaction (qRT-PCR) was conducted to detect the expression pattern of GABPA… read more here.
Keywords: protects gastric; gabpa; gastric cancer; gpx1 ... See more keywords