Combined blockade of GPX4 and activated EGFR/HER3 bypass pathways inhibits the development of ALK‐inhibitor‐induced tolerant persister cells in ALK ‐fusion‐positive lung cancer
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13746
Abstract: Cancers can develop resistance to treatment with ALK tyrosine kinase inhibitors (ALK‐TKIs) via emergence of a subpopulation of drug‐tolerant persister (DTP) cells that can survive initial drug treatment long enough to acquire genetic aberrations. DTP… read more here.
Keywords: cell; inhibitor; gpx4; bypass ... See more keywords
Exploiting Cancer Vulnerabilities by Blocking of the DHODH and GPX4 Pathways: A Multifunctional Bodipy/PROTAC Nanoplatform for the Efficient Synergistic Ferroptosis Therapy.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202300871
Abstract: Ferroptosis is a form of programmed cell death and plays an important role in many diseases. Dihydroorotate dehydrogenase (DHODH) and glutathione peroxidase 4 (GPX4) play major roles in cell resistance to ferroptosis. Therefore, inactivation of… read more here.
Keywords: ferroptosis therapy; dhodh; protac; gpx4 ... See more keywords
Engineering Iridium Nanoclusters for Boosting Ferroptotic Cell Death by Regulating GPX4 and p53 Functions
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202404895
Abstract: Emerging evidence indicates that modulating glutathione peroxidase 4 (GPX4) to induce ferroptosis is a promising strategy for tumor treatment. However, most of the GPX4 small molecule inhibitors face limitations due to their poor delivery efficacy… read more here.
Keywords: p53; ferroptosis; engineering iridium; iridium nanoclusters ... See more keywords
Baicalin Promotes Recovery Following Intracerebral Hemorrhage by Inhibiting Ferroptosis in Brain Tissue Through Modulation of AKT/Nrf2/GPX4 Axis
Sign Up to like & getrecommendations! Published in 2025 at "Drug Development Research"
DOI: 10.1002/ddr.70174
Abstract: Intracerebral hemorrhage (ICH) is a serious acute cerebrovascular disease with a high death and disability rate. Baicalin plays a neuroprotective role in various diseases, but its regulatory mechanism on ICH remains unclear. In this study,… read more here.
Keywords: baicalin; brain; ich mouse; mouse model ... See more keywords
Function and regulation of GPX4 in the development and progression of fibrotic disease
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30780
Abstract: Fibrosis is a common feature of fibrotic diseases that poses a serious threat to global health due to high morbidity and mortality in developing countries. There exist some chemical compounds and biomolecules associated with the… read more here.
Keywords: development; gpx4; function regulation; fibrotic disease ... See more keywords
Targeting GPX4 to Overcome Sorafenib Resistance of Human Hepatocellular Carcinoma by Inducing Ferroptosis
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.70078
Abstract: Hepatocellular carcinoma (HCC) is one of the leading causes of cancer death. Sorafenib, a multikinase inhibitor, has been approved as a first‐line systemic therapeutic for HCC patients based on the results of two large clinical… read more here.
Keywords: sorafenib; sorafenib resistance; hepatocellular carcinoma; ferroptosis ... See more keywords
Copper-Doped Polydopamine Nanoparticles-Mediated GSH/GPX4-Depleted Ferroptosis and Cuproptosis Sensitizes Lung Tumor to Checkpoint Blockade Immunotherapy.
Sign Up to like & getrecommendations! Published in 2025 at "Small"
DOI: 10.1002/smll.202503208
Abstract: Immune checkpoint blockade (ICB) therapy offers hope for improved outcomes in lung cancer treatment, but its effectiveness is restricted by the presence of an immunosuppressive tumor microenvironment (TME), resulting in a limited response rate (<… read more here.
Keywords: ferroptosis cuproptosis; cuproptosis; checkpoint blockade; lung tumor ... See more keywords
Se‐Methylselenocysteine Ameliorates DEHP‐Induced Ferroptosis in Testicular Sertoli Cells via the Nrf2/GPX4 Axis
Sign Up to like & getrecommendations! Published in 2024 at "Environmental Toxicology"
DOI: 10.1002/tox.24425
Abstract: Di (2‐ethylhexyl) phthalate (DEHP) is an important plasticizer in industrial production, and its toxic effects on testes are widely recognized. Se‐methylselenocysteine (SMC) is a major selenium compound found in selenium‐rich plants, which possesses unique biological… read more here.
Keywords: dehp induced; ameliorates dehp; induced ferroptosis; smc ... See more keywords
Relationship of organic mineral supplementation and spermatozoa/white blood cells mRNA in goats.
Sign Up to like & getrecommendations! Published in 2018 at "Animal reproduction science"
DOI: 10.1016/j.anireprosci.2018.08.044
Abstract: The antioxidant properties and the protective role of organic zinc (Zn) and copper (Cu) in white blood cells (WBCs) and spermatozoa were analyzed through quantification of superoxide dismutase 1 (SOD1), catalase (CAT), glutathione peroxidase 4… read more here.
Keywords: white blood; abundance; gpx4; blood cells ... See more keywords
p53 knock-down and hypoxia affects glutathione peroxidase 4 antioxidant response in hepatopancreas of the white shrimp Litopenaeus vannamei.
Sign Up to like & getrecommendations! Published in 2022 at "Biochimie"
DOI: 10.1016/j.biochi.2022.03.010
Abstract: Hypoxia ( read more here.
Keywords: hypoxia; gpx4; p53; vannamei ... See more keywords
GPx4 is the controller of a specific form of programmed cell death executed by lipid peroxidation products
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.05.015
Abstract: The recent identification of a routine of non-apoptotic controlled cell death recapitulates in a physiological perspective the long history of oxygen toxicity and lipid peroxidation. Due to the critical role of iron, this form of… read more here.
Keywords: oxygen; death; lipid peroxidation; gpx4 ... See more keywords