Exploiting Cancer Vulnerabilities by Blocking of the DHODH and GPX4 Pathways: A Multifunctional Bodipy/PROTAC Nanoplatform for the Efficient Synergistic Ferroptosis Therapy.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202300871
Abstract: Ferroptosis is a form of programmed cell death and plays an important role in many diseases. Dihydroorotate dehydrogenase (DHODH) and glutathione peroxidase 4 (GPX4) play major roles in cell resistance to ferroptosis. Therefore, inactivation of… read more here.
Keywords: ferroptosis therapy; dhodh; protac; gpx4 ... See more keywords
Function and regulation of GPX4 in the development and progression of fibrotic disease
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30780
Abstract: Fibrosis is a common feature of fibrotic diseases that poses a serious threat to global health due to high morbidity and mortality in developing countries. There exist some chemical compounds and biomolecules associated with the… read more here.
Keywords: development; gpx4; function regulation; fibrotic disease ... See more keywords
Relationship of organic mineral supplementation and spermatozoa/white blood cells mRNA in goats.
Sign Up to like & getrecommendations! Published in 2018 at "Animal reproduction science"
DOI: 10.1016/j.anireprosci.2018.08.044
Abstract: The antioxidant properties and the protective role of organic zinc (Zn) and copper (Cu) in white blood cells (WBCs) and spermatozoa were analyzed through quantification of superoxide dismutase 1 (SOD1), catalase (CAT), glutathione peroxidase 4… read more here.
Keywords: white blood; abundance; gpx4; blood cells ... See more keywords
p53 knock-down and hypoxia affects glutathione peroxidase 4 antioxidant response in hepatopancreas of the white shrimp Litopenaeus vannamei.
Sign Up to like & getrecommendations! Published in 2022 at "Biochimie"
DOI: 10.1016/j.biochi.2022.03.010
Abstract: Hypoxia ( read more here.
Keywords: hypoxia; gpx4; p53; vannamei ... See more keywords
GPx4 is the controller of a specific form of programmed cell death executed by lipid peroxidation products
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.05.015
Abstract: The recent identification of a routine of non-apoptotic controlled cell death recapitulates in a physiological perspective the long history of oxygen toxicity and lipid peroxidation. Due to the critical role of iron, this form of… read more here.
Keywords: oxygen; death; lipid peroxidation; gpx4 ... See more keywords
Production and purification of homogenous recombinant human selenoproteins reveals a unique codon skipping event in E. coli and GPX4-specific affinity to bromosulfophthalein
Sign Up to like & getrecommendations! Published in 2021 at "Redox Biology"
DOI: 10.1016/j.redox.2021.102070
Abstract: Selenoproteins are translated via animal domain-specific elongation machineries that redefine dedicated UGA opal codons from termination of translation to selenocysteine (Sec) insertion, utilizing specific tRNA species and Sec-specific elongation factors. This has made recombinant production… read more here.
Keywords: sec contents; production; sec; gpx4 ... See more keywords
PDTAC: Targeted Photodegradation of GPX4 Triggers Ferroptosis and Potent Antitumor Immunity.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00855
Abstract: Targeted degradation of proteins, especially those regarded as undruggable or difficult to drug, attracts wide attention to develop novel therapeutic strategies. Glutathione peroxidase 4 (GPX4), the key enzyme regulating ferroptosis, is currently a target with… read more here.
Keywords: targeted photodegradation; gpx4; antitumor immunity; pdtac targeted ... See more keywords
Cancer: Ironing it out
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DOI: 10.1038/nrd.2017.168
Abstract: properties are more likely to become resistant to a wide range of therapies. A new study suggests that this mesenchymal-like state of cancer cells is vulnerable to inhibition of the lipid peroxidase pathway, leading to… read more here.
Keywords: state; inhibition; high mesenchymal; gpx4 ... See more keywords
Glutathione peroxidase 4 overexpression inhibits ROS-induced cell death in diffuse large B-cell lymphoma
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DOI: 10.1038/s41374-017-0008-1
Abstract: Regulation of oxidative stress and redox systems has important roles in carcinogenesis and cancer progression, and for this reason has attracted much attention as a new area of cancer therapeutic targets. Glutathione peroxidase 4 (GPX4),… read more here.
Keywords: cell; gpx4; large cell; cell death ... See more keywords
Dietary lipids fuel GPX4-restricted enteritis resembling Crohn’s disease
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DOI: 10.1038/s41467-020-15646-6
Abstract: The increased incidence of inflammatory bowel disease (IBD) has become a global phenomenon that could be related to adoption of a Western life-style. Westernization of dietary habits is partly characterized by enrichment with the ω-6… read more here.
Keywords: disease; gpx4; gpx4 restricted; dietary lipids ... See more keywords
Guilu-Erxian-Glue alleviates Tripterygium wilfordii polyglycoside-induced oligoasthenospermia in rats by resisting ferroptosis via the Keap1/Nrf2/GPX4 signaling pathway
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutical Biology"
DOI: 10.1080/13880209.2023.2165114
Abstract: Abstract Context Guilu-Erxian-Glue (GLEXG) is a traditional Chinese formula used to improve male reproductive dysfunction. Objective To investigate the ferroptosis resistance of GLEXG in the improvement of semen quality in the oligoasthenospermia (OAS) rat model.… read more here.
Keywords: nrf2 gpx4; histopathology; keap1 nrf2; gpx4 ... See more keywords