Extent of Tumor Resection and Survival in Pediatric Patients With High-Grade Gliomas
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.26551
Abstract: This systematic review and meta-analysis describes postoperative outcomes associated with gross total resection, subtotal resection, and biopsy in children with high-grade gliomas. read more here.
Keywords: high grade; grade gliomas; tumor resection; resection ... See more keywords
Adjuvant Temozolomide Chemotherapy With or Without Interferon Alfa Among Patients With Newly Diagnosed High-grade Gliomas: A Randomized Clinical Trial.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA network open"
DOI: 10.1001/jamanetworkopen.2022.53285
Abstract: Importance High-grade gliomas (HGGs) constitute the most common and aggressive primary brain tumor, with 5-year survival rates of 30.9% for grade 3 gliomas and 6.6% for grade 4 gliomas. The add-on efficacy of interferon alfa… read more here.
Keywords: grade gliomas; patients newly; newly diagnosed; alfa ... See more keywords
Probing the phosphatidylinositol 3‐kinase/mammalian target of rapamycin pathway in gliomas: A phase 2 study of everolimus for recurrent adult low‐grade gliomas
Sign Up to like & getrecommendations! Published in 2017 at "Cancer"
DOI: 10.1002/cncr.30909
Abstract: Activation of the phosphatidylinositol 3‐kinase (PI3K)/mammalian target of rapamycin (mTOR) pathway is common in patients with low‐grade gliomas (LGGs), but agents that inhibit this pathway, including mTOR inhibitors, have not been studied in this population. read more here.
Keywords: gliomas; mammalian target; phosphatidylinositol kinase; target rapamycin ... See more keywords
Genetic driver mutations define the expression signature and microenvironmental composition of high‐grade gliomas
Sign Up to like & getrecommendations! Published in 2017 at "Glia"
DOI: 10.1002/glia.23203
Abstract: High‐grade gliomas (HGG), including glioblastomas, are characterized by invasive growth, resistance to therapy, and high inter‐ and intra‐tumoral heterogeneity. The key histological hallmarks of glioblastoma are pseudopalisading necrosis and microvascular proliferation, which allow pathologists to… read more here.
Keywords: driver; high grade; grade; expression ... See more keywords
Amide proton transfer-weighted MRI in distinguishing high- and low-grade gliomas: a systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2018 at "Neuroradiology"
DOI: 10.1007/s00234-018-02152-2
Abstract: PurposeGrading of brain gliomas is of clinical importance, and noninvasive molecular imaging may help differentiate low- and high-grade gliomas. We aimed to evaluate the diagnostic performance of amide proton transfer-weighted (APTw) MRI for differentiating low-… read more here.
Keywords: gliomas; aptw mri; high grade; grade ... See more keywords
Management and outcome of pediatric brainstem and cerebellar peduncular low-grade gliomas: a retrospective analysis of 62 cases
Sign Up to like & getrecommendations! Published in 2021 at "Child's Nervous System"
DOI: 10.1007/s00381-021-05405-3
Abstract: This study was designed to present our experience and recommendations regarding the management of pediatric brainstem and peduncular low-grade gliomas (LGGs). Retrospective analysis was performed for pathologically proven brainstem or cerebellar peduncular LGGs in patients… read more here.
Keywords: peduncular low; peduncular; brainstem; grade gliomas ... See more keywords
Intracavitary radioimmunotherapy of high-grade gliomas: present status and future developments
Sign Up to like & getrecommendations! Published in 2019 at "Acta Neurochirurgica"
DOI: 10.1007/s00701-019-03882-9
Abstract: There is a distinct need for new and second-line therapies to delay or prevent local tumor regrowth after current standard of care therapy. Intracavitary radioimmunotherapy, in combination with radiotherapy, is discussed in the present review… read more here.
Keywords: gliomas present; high grade; future; intracavitary radioimmunotherapy ... See more keywords
Pediatric high-grade glioma: current molecular landscape and therapeutic approaches
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-017-2393-0
Abstract: High-grade pediatric central nervous system glial tumors are comprised primarily of anaplastic astrocytomas (AA, WHO grade III) and glioblastomas (GBM, WHO grade IV). High-grade gliomas are most commonly diagnosed in the primary setting in children,… read more here.
Keywords: pediatric high; high grade; grade glioma; grade ... See more keywords
IDH mutation status trumps the Pignatti risk score as a prognostic marker in low-grade gliomas
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-017-2570-1
Abstract: Management of low-grade gliomas (LGG) is based on clinical and radiologic features, including the Pignatti prognostic scoring system, which classifies patients as low- or high-risk. To determine whether molecular data can offer advantages over these… read more here.
Keywords: risk; mutations 19q; idh mutations; grade gliomas ... See more keywords
Characterization of iPSCs derived from low grade gliomas revealed early regional chromosomal amplifications during gliomagenesis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-018-03047-1
Abstract: IntroductionIDH1 mutation has been identified as an early genetic event driving low grade gliomas (LGGs) and it has been proven to exerts a powerful epigenetic effect. Cells containing IDH1 mutation are refractory to epigenetical reprogramming… read more here.
Keywords: ipsc clones; regional chromosomal; idh1 mutation; grade gliomas ... See more keywords
Retrospective study of nivolumab for patients with recurrent high grade gliomas
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-018-2907-4
Abstract: IntroductionPatients with recurrent high-grade gliomas (HGG) have limited treatment options. HGG utilize the PD-1 pathway to evade immune responses. Checkpoint inhibitors have demonstrated safety and clinical activity in patients with recurrent glioblastoma. We explored the… read more here.
Keywords: high grade; received nivolumab; grade gliomas; patients recurrent ... See more keywords