Systemic and local immunosuppression in patients with high-grade meningiomas
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-019-02342-8
Abstract: AimDespite current treatments, high-grade meningiomas continue to have a poor prognosis. Immunotherapy targeting immune checkpoints, such as PD-L1, has demonstrated significant success in controlling numerous malignancies. In this study, we investigate the extent of systemic… read more here.
Keywords: grade meningiomas; high grade; grade; systemic local ... See more keywords
DMD genomic deletions characterize a subset of progressive/higher-grade meningiomas with poor outcome
Sign Up to like & getrecommendations! Published in 2018 at "Acta Neuropathologica"
DOI: 10.1007/s00401-018-1899-7
Abstract: Progressive meningiomas that have failed surgery and radiation have a poor prognosis and no standard therapy. While meningiomas are more common in females overall, progressive meningiomas are enriched in males. We performed a comprehensive molecular… read more here.
Keywords: grade meningiomas; meningiomas; grade; subset progressive ... See more keywords
Genetic and epigenetic alterations in meningiomas
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Neurology and Neurosurgery"
DOI: 10.1016/j.clineuro.2017.05.002
Abstract: Meningiomas originate from the arachnoid layer of the meninges and divided histologically into three grades: benign (grade I), atypical (grade II), and malignant meningiomas (grade III). Genetic alterations in grade I meningiomas include frequent deletions… read more here.
Keywords: grade meningiomas; alterations meningiomas; meningiomas; genetic epigenetic ... See more keywords
Relevance of Simpson's grading system for resections in WHO grade I meningiomas
Sign Up to like & getrecommendations! Published in 2017 at "Neurocirugia"
DOI: 10.1016/j.neucie.2017.06.005
Abstract: Abstract Object The aim of this study is to assess if the recurrence rates and recurrence/progression-free survivals (RFS) are different after Simpson's grades I, II, III and IV resections in World Health Organisation (WHO) grade… read more here.
Keywords: grade meningiomas; recurrence rates; simpson grades; simpson ... See more keywords
[Relevance of Simpson's grading system for resections in WHO grade I meningiomas].
Sign Up to like & getrecommendations! Published in 2017 at "Neurocirugia"
DOI: 10.1016/j.neucir.2016.12.001
Abstract: OBJECT The aim of this study is to assess if the recurrence rates and recurrence/progression-free survivals (RFS) are different after Simpson's grades I, II, III and IV resections in World Health Organization (WHO) grade I… read more here.
Keywords: grade meningiomas; recurrence rates; simpson grades; simpson ... See more keywords
Infarction with associated pseudosarcomatous changes mimics anaplasia in otherwise grade I meningiomas
Sign Up to like & getrecommendations! Published in 2020 at "Modern Pathology"
DOI: 10.1038/s41379-020-0491-6
Abstract: We describe a morphologically distinct pattern of tumor infarction and associated sarcoma-like changes, mimicking focal anaplasia, in otherwise WHO grade I meningiomas. The described cases ( n = 9) all demonstrated a discrete spindle-cell (pseudosarcomatous) component… read more here.
Keywords: otherwise grade; grade meningiomas; meningiomas; anaplasia otherwise ... See more keywords
Phase 2 study of pembrolizumab in patients with recurrent and residual high-grade meningiomas
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-022-29052-7
Abstract: High-grade meningiomas are associated with neuro-cognitive morbidity and have limited treatments. High-grade meningiomas harbor an immunosuppressive tumor microenvironment (TME) and programmed death-ligand 1 (PD-L1) expression may contribute to their aggressive phenotype. Here, we present the… read more here.
Keywords: patients recurrent; high grade; phase; grade meningiomas ... See more keywords
Histological transformation in recurrent WHO grade I meningiomas
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-68177-x
Abstract: Atypical or malignant transformation (AT/MT) has been described in WHO grade I meningiomas. Our aim was to identify predictive factors of AT/MT at recurrence. A total of N = 15 WHO grade increases were observed in N = 13… read more here.
Keywords: grade meningiomas; transformation recurrent; histological transformation; transformation ... See more keywords
Intratumoral heterogeneity and TERT promoter mutations in progressive/higher-grade meningiomas
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.22650
Abstract: Background Recent studies have reported mutations in the telomerase reverse transcriptase promoter (TERTp) in meningiomas. We sought to determine the frequency, clonality and clinical significance of telomere gene alterations in a cohort of patients with… read more here.
Keywords: grade meningiomas; higher grade; grade; progressive higher ... See more keywords
Efficacy of Bevacizumab in High-Grade Meningiomas: A Retrospective Clinical Study
Sign Up to like & getrecommendations! Published in 2022 at "Neuropsychiatric Disease and Treatment"
DOI: 10.2147/ndt.s368740
Abstract: Objective We investigated the role of bevacizumab (BV) in high-grade meningiomas (HGMs) by retrospective analysis. Methods We retrospectively analyzed the clinical data of 139 patients with HGMs. The chi-square test was used to compare progression-free… read more here.
Keywords: high grade; pfs; bevacizumab high; group ... See more keywords
Advances in Molecular Biological and Translational Studies in World Health Organization Grades 2 and 3 Meningiomas: A Literature Review
Sign Up to like & getrecommendations! Published in 2022 at "Neurologia medico-chirurgica"
DOI: 10.2176/jns-nmc.2022-0114
Abstract: The treatment of World Health Organization (WHO) grades 2 and 3 meningiomas remains difficult and controversial. The pathogenesis of high-grade meningiomas was expected to be elucidated to improve treatment strategies. The molecular biology of meningiomas… read more here.
Keywords: health organization; grades meningiomas; organization grades; meningiomas ... See more keywords