High-grade neuroendocrine carcinoma of the urachus-report of 3 cases.
Sign Up to like & getrecommendations! Published in 2017 at "Human pathology"
DOI: 10.1016/j.humpath.2017.08.003
Abstract: Most urachal malignancies are composed of pure adenocarcinoma with mucin production. Urachal neuroendocrine carcinoma (NEC) is extremely rare, with only a few cases reported in the literature. Here we report 3 cases of urachal NEC,… read more here.
Keywords: carcinoma; high grade; report cases; grade neuroendocrine ... See more keywords
A comparison of adult rhabdomyosarcoma and high-grade neuroendocrine carcinoma of the urinary bladder reveals novel PPP1R12A fusions in rhabdomyosarcoma.
Sign Up to like & getrecommendations! Published in 2019 at "Human pathology"
DOI: 10.1016/j.humpath.2019.03.007
Abstract: Some rhabdomyosarcomas and sarcomatoid carcinomas with heterologous rhabdomyosarcomatous elements resemble high-grade neuroendocrine carcinoma, creating a diagnostic difficulty. The purpose of this study was to characterize the overlap of adult genitourinary rhabdomyosarcomas, excluding those occurring at… read more here.
Keywords: neuroendocrine carcinoma; grade neuroendocrine; neuroendocrine; high grade ... See more keywords
Pembrolizumab monotherapy in patients with previously treated metastatic high-grade neuroendocrine neoplasms: joint analysis of two prospective, non-randomised trials
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Cancer"
DOI: 10.1038/s41416-020-0775-0
Abstract: Background Metastatic high-grade neuroendocrine neoplasms (G3NENs) have limited treatment options after progression on platinum-based therapy. We addressed the role of Pembrolizumab in patients with previously treated metastatic G3NENs. Methods Two open-label, phase 2 studies enrolled… read more here.
Keywords: high grade; grade; patients previously; neuroendocrine neoplasms ... See more keywords
EpiCO (epirubicin, cyclophosphamide and vincristine) as treatment for extrapulmonary high-grade neuroendocrine neoplasms.
Sign Up to like & getrecommendations! Published in 2020 at "Zeitschrift fur Gastroenterologie"
DOI: 10.1055/a-1042-6504
Abstract: High-grade neuroendocrine neoplasms (NEN) comprise a rare entity. Due to the lack of randomized controlled trials, therapy recommendations were mainly extrapolated from its pulmonary analogue, small cell lung cancer and mostly validated in small retrospective… read more here.
Keywords: grade; high grade; treatment; neuroendocrine neoplasms ... See more keywords
Solitary Cardiac Low-Grade Neuroendocrine Tumor: A Case Report and Review of the Literature
Sign Up to like & getrecommendations! Published in 2020 at "American Journal of Clinical Pathology"
DOI: 10.1093/ajcp/aqaa161.100
Abstract: Primary tumors of the heart are uncommon; even rarer are primary cardiac neuroendocrine tumors. To our knowledge, only two cases have been described to date, both being high-grade tumors. We report a solitary low-grade neuroendocrine… read more here.
Keywords: neuroendocrine tumor; low grade; grade neuroendocrine; tumor ... See more keywords
Well-Differentiated Grade 3 Neuroendocrine Tumors
Sign Up to like & getrecommendations! Published in 2022 at "Pancreas"
DOI: 10.1097/mpa.0000000000002100
Abstract: Objectives We evaluated a population-based cohort of metastatic well-differentiated grade 3 gastroenteropancreatic neuroendocrine tumors (G3 NETs) to describe their characteristics, prognosis, and treatment outcomes. Methods The British Columbia provincial database was queried for G3 NETs… read more here.
Keywords: differentiated grade; grade neuroendocrine; neuroendocrine tumors; well differentiated ... See more keywords
Clinical significance of MYC family protein expression in surgically resected high‐grade neuroendocrine carcinoma of the lung
Sign Up to like & getrecommendations! Published in 2023 at "Thoracic Cancer"
DOI: 10.1111/1759-7714.14804
Abstract: MYC family genes including MYC, MYCN, and MYCL are amplified and overexpressed as oncogenic drivers in high‐grade neuroendocrine carcinoma of the lung (HGNEC), but little is known about their clinical significance. This study evaluated the… read more here.
Keywords: myc family; grade neuroendocrine; high grade; family ... See more keywords
Exploratory genomic analysis of high grade neuroendocrine neoplasms across diverse primary sites.
Sign Up to like & getrecommendations! Published in 2022 at "Endocrine-related cancer"
DOI: 10.1530/erc-22-0015
Abstract: High grade (grade 3) neuroendocrine neoplasms (G3 NENs) have poor survival outcomes. From a clinical standpoint, G3 NENs are usually grouped regardless of primary site and treated similarly. Little is known regarding the underlying genomics… read more here.
Keywords: grade neuroendocrine; high grade; neuroendocrine neoplasms; primary sites ... See more keywords
The Role of Surgery in High-Grade Neuroendocrine Cancer: Indications for Clinical Practice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.869320
Abstract: Pulmonary neuroendocrine tumors (pNET) represent a particular type of malignant lung cancers and can be divided into well-differentiated low-grade NET and poorly-differentiated high-grade NET. Typical and atypical carcinoids belong to the first group while large… read more here.
Keywords: grade neuroendocrine; high grade; role; surgery ... See more keywords
Biomarkers of Response to Etoposide-Platinum Chemotherapy in Patients with Grade 3 Neuroendocrine Neoplasms
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13040643
Abstract: Simple Summary Grade 3 neuroendocrine neoplasms (G3 NEN) are a heterogenous subtype of NEN, including well-differentiated neuroendocrine tumors (G3 NET) and poorly differentiated large- or small-cell type carcinomas (NEC). Until recently, all G3 NEN were… read more here.
Keywords: chemotherapy; response; biomarkers response; neuroendocrine neoplasms ... See more keywords
Exploration of Novel Prognostic Markers in Grade 3 Neuroendocrine Neoplasia
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13164232
Abstract: Simple Summary High grade neuroendocrine tumours and carcinomas (NETs/NECs) behave aggressively and have limited survival outcomes. The mainstay of therapy is systemic therapy, in which the associated side-effects are a key consideration in a palliative… read more here.
Keywords: grade net; high grade; treatment; grade neuroendocrine ... See more keywords