ONC201 induces the unfolded protein response (UPR) in high‐ and low‐grade ovarian carcinoma cell lines and leads to cell death regardless of platinum sensitivity
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Medicine"
DOI: 10.1002/cam4.3858
Abstract: Treatment of both platinum resistant high grade (HG) and low‐grade (LG) ovarian cancer (OVCA) poses significant challenges as neither respond well to conventional chemotherapy leading to morbidity and mortality. Identification of novel agents that can… read more here.
Keywords: platinum; unfolded protein; grade ovarian; low grade ... See more keywords
Functional estrogen receptor signal transduction pathway activity and antihormonal therapy response in low‐grade ovarian carcinoma
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DOI: 10.1002/cncr.34661
Abstract: Advanced low‐grade ovarian carcinoma (LGOC) is difficult to treat. In several studies, high estrogen receptor (ER) protein expression was observed in patients with LGOC, which suggests that antihormonal therapy (AHT) is a treatment option. However,… read more here.
Keywords: estrogen receptor; activity; low grade; grade ovarian ... See more keywords
Similar Overall Survival Using Neoadjuvant Chemotherapy or Primary Debulking Surgery in Patients Aged Over 75 Years with High-Grade Ovarian Cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC"
DOI: 10.1016/j.jogc.2020.04.014
Abstract: OBJECTIVE To perform a hypothesis-generating evaluation of patient outcomes following neoadjuvant chemotherapy (NACT) compared with those following primary debulking surgery (PDS) in patients over age 75 with high-grade ovarian cancer. METHODS This was a retrospective… read more here.
Keywords: grade ovarian; ovarian cancer; survival; high grade ... See more keywords
Robustness of RNA sequencing on older formalin-fixed paraffin-embedded tissue from high-grade ovarian serous adenocarcinomas
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DOI: 10.1371/journal.pone.0216050
Abstract: Formalin-fixed paraffin-embedded (FFPE) tissues are among the most widely available clinical specimens. Their potential utility as a source of RNA for transcriptome studies would greatly enhance population-based cancer studies. Although preliminary studies suggest FFPE tissue… read more here.
Keywords: ovarian serous; high grade; grade ovarian; rna ... See more keywords
Low-Grade Ovarian Serous Adenocarcinoma with Lymph Node Metastasis in Neck
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DOI: 10.3390/diagnostics11101804
Abstract: Low-grade ovarian serous adenocarcinoma is rarely encountered in the neck region. The diagnosis of this rare malignancy entity in the neck is challenging for both clinicians and pathologists. A 53-year-old female with a chief complaint… read more here.
Keywords: ovarian serous; neck; lymph; grade ovarian ... See more keywords
Gene microarray analysis of lncRNA and mRNA expression profiles in patients with high-grade ovarian serous cancer
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Molecular Medicine"
DOI: 10.3892/ijmm.2018.3588
Abstract: High-grade ovarian serous cancer is known for its high rates of invasion and metastasis, and resultant high mortality rate. Therefore, research concerning biomarkers and underlying molecular mechanisms of high-grade ovarian serous cancer progression and prognosis… read more here.
Keywords: ovarian serous; high grade; grade ovarian; serous cancer ... See more keywords