Spatial cytotoxic and memory T cells in tumor predict superior survival outcomes in patients with high‐grade serous ovarian cancer
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Medicine"
DOI: 10.1002/cam4.3942
Abstract: Although the association between tumor‐infiltrating CD3+ T and CD8+ T cells and superior survival in high‐grade serous ovarian cancer (HGSOC) has been observed, the different spatial localization of tumor‐infiltrating lymphocytes (TILs) possesses heterogeneous effects. We… read more here.
Keywords: grade serous; cd8; high grade; cancer ... See more keywords
Molecular and phenotypic characteristics influencing the degree of cytoreduction in high-grade serous ovarian carcinomas.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer medicine"
DOI: 10.1002/cam4.6085
Abstract: BACKGROUND High-grade serous ovarian carcinoma (HGSOC) is the deadliest ovarian cancer subtype, and survival relates to initial cytoreductive surgical treatment. The existing tools for surgical outcome prediction remain inadequate for anticipating the outcomes of the… read more here.
Keywords: high grade; grade serous; hgsoc; serous ovarian ... See more keywords
Beyond the estrogen receptor: In search of predictive biomarkers for low‐grade serous ovarian cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer"
DOI: 10.1002/cncr.34658
Abstract: Low ‐ grade ovarian cancer (LGOC) comprises a rare group of tumors, including serous, mucinous, and endometrioid subtypes, that collectively account for 10% of ovarian cancer (OC) deaths and are histologically and molecularly distinct from… read more here.
Keywords: estrogen receptor; grade serous; ovarian cancer; low grade ... See more keywords
Monitoring the extracellular matrix remodeling of high-grade serous ovarian cancer with nonlinear optical microscopy.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of biophotonics"
DOI: 10.1002/jbio.202000498
Abstract: The mortality of high-grade serous ovarian cancer (HGSOC) accounts for 70%-80% of all ovarian cancer deaths and overall mortality rate has not declined in the last decade . Recently, many studies have demonstrated that HGSOC… read more here.
Keywords: serous ovarian; grade serous; high grade; microscopy ... See more keywords
Integrative prognostic subtype discovery in high‐grade serous ovarian cancer
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DOI: 10.1002/jcb.29049
Abstract: We sought to identify novel molecular subtypes of high‐grade serous ovarian cancer (HGSC) by the integration of gene expression and proteomics data and to find the underlying biological characteristics of ovarian cancer to improve the… read more here.
Keywords: serous ovarian; grade serous; high grade; ovarian cancer ... See more keywords
Diffusion‐Weighted Magnetic Resonance Imaging and Morphological Characteristics Evaluation for Outcome Prediction of Primary Debulking Surgery for Advanced High‐Grade Serous Ovarian Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Magnetic Resonance Imaging"
DOI: 10.1002/jmri.28418
Abstract: Preoperative assessment of whether a successful primary debulking surgery (PDS) can be performed in patients with advanced high‐grade serous ovarian carcinoma (HGSOC) remains a challenge. A reliable model to precisely predict resectability is highly demanded. read more here.
Keywords: advanced high; high grade; grade serous; primary debulking ... See more keywords
Factors associated with the involvement of lymph nodes in low-grade serous ovarian cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of surgical oncology"
DOI: 10.1002/jso.26700
Abstract: BACKGROUND AND OBJECTIVES Evaluating nodal metastases in low-grade serous ovarian cancer (LGSOC) patients. METHODS Women with LGSOC who had undergone primary cytoreductive surgery comprising systematic pelvic-paraaortic lymphadenectomy were included. Data were obtained retrospectively from 12… read more here.
Keywords: serous ovarian; grade serous; lymph nodes; ovarian cancer ... See more keywords
Loss of CBX2 causes genomic instability and Wnt activation in high grade serous ovarian carcinoma cells
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23500
Abstract: High grade serous ovarian carcinoma (HGSOC) is lethal with insidious onset, rapid progression, poor prognosis, and limited treatment options. Polycomb repressor complexes (PRC) 1 and 2 are intimately involved in progression of many types of… read more here.
Keywords: high grade; grade serous; cbx2; hgsoc ... See more keywords
Differential histone deacetylase inhibitor-induced perturbations of the global proteome landscape in the setting of high-grade serous ovarian cancer
Sign Up to like & getrecommendations! Published in 2022 at "Proteomics"
DOI: 10.1002/pmic.202100372
Abstract: High‐grade serous ovarian cancer (HGSOC) is the most lethal gynecologic malignancy in women. Its low survival rate is attributed to late detection, relapse, and drug resistance. The lack of effective second‐line therapeutics remains a significant… read more here.
Keywords: high grade; grade serous; ovarian cancer; hgsoc ... See more keywords
Activity and clinical relevance of autotaxin and lysophosphatidic acid pathways in high-grade serous carcinoma
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DOI: 10.1007/s00428-018-2418-x
Abstract: The aim of this study was to analyze the expression, biological role and clinical relevance of autotaxin (ATX), the enzyme synthetizing lysophosphatidic acid (LPA), and LPA receptors (LPAR) in high-grade serous carcinoma (HGSC). mRNA expression… read more here.
Keywords: grade serous; clinical relevance; high grade; expression ... See more keywords
Comprehensive in situ analysis of ALDH1 and SOX2 reveals increased expression of stem cell markers in high-grade serous carcinomas compared to low-grade serous carcinomas and atypical proliferative serous tumors
Sign Up to like & getrecommendations! Published in 2019 at "Virchows Archiv"
DOI: 10.1007/s00428-019-02647-0
Abstract: Recent studies have shown that re-expression of stem cell factors contribute to pathogenesis, therapy resistance, and recurrent disease in ovarian carcinomas. In this study, we compare the expression and co-expression of stem cell markers ALDH1… read more here.
Keywords: stem cell; serous carcinomas; grade serous; expression ... See more keywords