Biomarker profile predicts clinical efficacy of extracorporeal photopheresis in steroid‐resistant acute and chronic graft‐vs‐host disease after allogenic hematopoietic stem cell transplant
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Apheresis"
DOI: 10.1002/jca.21918
Abstract: We conducted a multicenter interventional study to assess the efficacy of Therakos ECP to treat steroid‐resistant graft‐vs‐host disease (SRes‐GVHD) after allogeneic HSCT and to identify biomarkers of GVHD response. A total of 62 patients were… read more here.
Keywords: response; sres gvhd; graft host; steroid resistant ... See more keywords
Role of extracorporeal photopheresis in the management of children with graft‐vs‐host disease
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Apheresis"
DOI: 10.1002/jca.22012
Abstract: Graft‐vs‐host disease (GVHD) is a frequent cause of morbidity and mortality in allogeneic stem cell transplants. Extracorporeal photopheresis (ECP) is one of the most accepted second‐line treatments, but technical issues of ECP in children might… read more here.
Keywords: extracorporeal photopheresis; host disease; graft host;
Acute Graft-vs-Host Disease After Liver Transplantation in a Patient Presenting With Neurogenic Symptoms as the Single Primary Manifestation: A Case Report.
Sign Up to like & getrecommendations! Published in 2018 at "Transplantation proceedings"
DOI: 10.1016/j.transproceed.2018.05.013
Abstract: Acute graft-vs-host disease (aGVHD) is a rare but deadly complication after liver transplantation (LT). It occurs when donor immunocompetent cells transplanted with the liver allograft repopulate and recognize recipient antigens as foreign and mount an… read more here.
Keywords: manifestation; graft host; transplantation; neurogenic symptoms ... See more keywords
Extracellular vesicles as potential biomarkers of acute graft-vs-host disease
Sign Up to like & getrecommendations! Published in 2018 at "Leukemia"
DOI: 10.1038/leu.2017.277
Abstract: Acute graft-vs-host disease (GVHD) is a serious complication after allografting. We carried out an exploratory study to investigate a potential correlation of surface antigens on extracellular vesicles (EVs) and acute GVHD. EVs were extracted from… read more here.
Keywords: extracellular vesicles; acute gvhd; graft host; host disease ... See more keywords
Role of Vessel Microstructure in the Longevity of End-to-side Grafts.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of biomechanical engineering"
DOI: 10.1115/1.4043873
Abstract: Compliance mismatch between the graft and the host artery of an end-to-side (ETS) arterial bypass graft increases the intramural stress in the ETS graft-artery junction, and thus may compromise its long-term patency. The present study… read more here.
Keywords: graft; graft host; bypass graft; host artery ... See more keywords
Prognostic Value of Blood Biomarkers in Steroid-Refractory/Dependent Acute Graft-vs-Host Disease: A REACH2 Analysis.
Sign Up to like & getrecommendations! Published in 2023 at "Blood"
DOI: 10.1182/blood.2022018579
Abstract: Systemic steroids are the standard first-line treatment for acute graft-vs-host disease (aGVHD), but approximately 50% of patients become steroid refractory or dependent (SR/D). Ruxolitinib is the only FDA and EMA approved therapy for patients with… read more here.
Keywords: day; host disease; reach2; acute graft ... See more keywords
Chronic graft-vs-host disease: Current understanding of disease and treatment landscape.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of managed care & specialty pharmacy"
DOI: 10.18553/jmcp.2022.28.12-b.s1
Abstract: Chronic graft-vs-host disease (cGVHD) is a common complication and a major cause of morbidity and mortality following allogeneic hematopoietic cell transplantation. It is primarily characterized by chronic inflammation and fibrosis involving multiple organs. Firstline treatment… read more here.
Keywords: chronic graft; disease; host disease; treatment ... See more keywords
A Possible Reason to Induce Acute Graft-vs.-Host Disease After Hematopoietic Stem Cell Transplantation: Lack of Sirtuin-1 in CD4+ T Cells
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.03078
Abstract: Sirtuin 1 (SIRT1) is a critical suppressor of T cell immunity. However, whether SIRT1 is involved in the progression of acute graft-vs.-host disease (aGVHD) has still remained unclear. PI3K/Akt/mTOR pathway is a crucial element involved… read more here.
Keywords: cd4 cells; graft host; activation; host disease ... See more keywords
Dendritic Cell Regulation of Graft-Vs.-Host Disease: Immunostimulation and Tolerance
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.00093
Abstract: Graft-vs.-host disease (GVHD) remains a significant cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Significant progresses have been made in defining the dichotomous role of dendritic cells (DCs) in the development… read more here.
Keywords: dcs; graft host; host; host disease ... See more keywords
Comparison of Mesenchymal Stromal Cells From Different Origins for the Treatment of Graft-vs.-Host-Disease in a Humanized Mouse Model
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.00619
Abstract: Mesenchymal stromal cells (MSCs) have potent immunomodulatory properties that make them an attractive tool against graft- vs.-host disease (GVHD). However, despite promising results in phase I/II studies, bone marrow (BM-) derived MSCs failed to demonstrate… read more here.
Keywords: mesenchymal stromal; stromal cells; graft host; host disease ... See more keywords
Acute Graft-vs.-Host Disease-Associated Endothelial Activation in vitro Is Prevented by Defibrotide
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.02339
Abstract: Angiogenesis and endothelial activation and dysfunction have been associated with acute graft-vs.-host disease (aGVHD), pointing to the endothelium as a potential target for pharmacological intervention. Defibrotide (DF) is a drug with an endothelium-protective effect that… read more here.
Keywords: agvhd; graft host; disease; activation ... See more keywords