Multiomics Analysis Identifies SOCS1 as Restraining T Cell Activation and Preventing Graft‐Versus‐Host Disease
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202200978
Abstract: Graft‐versus‐host disease (GVHD) is a major life‐threatening complication of allogeneic hematopoietic stem cell transplantation (allo‐HSCT). Inflammatory signaling pathways promote T‐cell activation and are involved in the pathogenesis of GVHD. Suppressor of cytokine signaling 1 (SOCS1)… read more here.
Keywords: gvhd; cell activation; analysis; graft versus ... See more keywords
Granulocyte colony‐stimulating factors and aortitis: A rare adverse event
Sign Up to like & getrecommendations! Published in 2018 at "American Journal of Hematology"
DOI: 10.1002/ajh.25220
Abstract: REFERENCES 1. Guo M, Hu KX, Liu GX, et al. HLA-mismatched stem-cell microtransplantation as postremission therapy for acute myeloid leukemia: long-term follow-up. J Clin Oncol. 2012;30:4084-4090. 2. Spitzer TR. Microtransplantation: a new paradigm for the… read more here.
Keywords: clin oncol; myeloid leukemia; colony stimulating; granulocyte colony ... See more keywords
Patient‐reported symptom burden and impact on daily activities in chronic graft‐versus‐host disease
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DOI: 10.1002/cam4.5209
Abstract: Chronic graft‐versus‐host disease (GVHD) is a potentially life‐threatening complication of allogeneic hematopoietic stem cell transplantation (HSCT) treatment for hematologic malignancies. There are limited patient‐reported data concerning symptom burden and effects on activities of daily living… read more here.
Keywords: symptom burden; chronic graft; patient reported; host disease ... See more keywords
During acute graft versus host disease CD28 deletion in donor CD8+, but not CD4+, T cells maintain antileukemia responses in mice
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Immunology"
DOI: 10.1002/eji.201847669
Abstract: Donor lymphocyte infusions together with allogeneic hematopoietic stem cell transplantation are routinely used as second‐line treatment for hematological malignancies. Mature T cells in the graft crucially mediate a graft versus leukemia (GvL) response, but also… read more here.
Keywords: donor; donor cd8; cd4; graft versus ... See more keywords
S1PR5 regulates NK cell responses in preventing graft‐versus‐host disease while preserving graft‐versus‐tumour activity in a murine allogeneic haematopoietic stem cell transplantation model
Sign Up to like & getrecommendations! Published in 2019 at "Hematological Oncology"
DOI: 10.1002/hon.2669
Abstract: Graft‐versus‐host disease (GVHD) remains a major complication following allogeneic haematopoietic stem cell transplantation (allo‐HSCT) leading to high transplant‐related mortality. Natural killer (NK) cells have been found to mitigate GVHD without attenuating the graft‐versus‐tumour (GVT) activity… read more here.
Keywords: graft; stem cell; s1pr5; haematopoietic stem ... See more keywords
Hyperspectral imaging to accurately segment skin erythema and hyperpigmentation in cutaneous chronic graft-versus-host disease.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of biophotonics"
DOI: 10.1002/jbio.202300009
Abstract: In 15 patients with the inflammatory skin condition chronic graft-versus-host-disease, hyperspectral imaging accurately delineated active erythema and post-inflammatory hyperpigmentation. The method was validated by dermatologist-approved confident delineations of only definitely affected and definitely unaffected areas… read more here.
Keywords: chronic graft; disease; hyperspectral imaging; hyperpigmentation ... See more keywords
Noncoding RNAs in diagnosis and prognosis of graft‐versus‐host disease (GVHD)
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DOI: 10.1002/jcp.30830
Abstract: Allogeneic hematopoietic stem cell transplantation (allo‐HSCT) is a functional therapy for a plethora of hematologic malignancies and immune disorders. Graft‐versus‐host disease (GVHD), on the other hand, is one of the major complications ahead of a… read more here.
Keywords: host disease; versus host; noncoding rnas; graft versus ... See more keywords
OSI‐027 modulates acute graft‐versus‐host disease after liver transplantation in a rat model
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DOI: 10.1002/lt.24797
Abstract: Despite its rarity (1%‐2%), acute graft‐versus‐host disease after liver transplantation (LT‐aGVHD) has a high mortality rate (85%). A gradual decrease in regulatory T cells (Tregs) correlates with disease progression in a rat LT‐GVHD model, and… read more here.
Keywords: osi 027; model; liver transplantation; acute graft ... See more keywords
Microbiome: an emerging new frontier in graft‑versus‑host disease
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DOI: 10.1007/s00011-020-01419-w
Abstract: The field around the microbiome and graft-versus-host disease (GVHD) is rapidly evolving and so is its literature. Therefore, we consider it important to provide an update on our recent review “Microbiome: An Emerging New Frontier… read more here.
Keywords: versus host; graft versus; host; host disease ... See more keywords
Compound heterozygous DCLRE1C mutations lead to clinically typical Severe Combined Immunodeficiency presenting with Graft Versus Host Disease.
Sign Up to like & getrecommendations! Published in 2021 at "Immunogenetics"
DOI: 10.1007/s00251-021-01219-4
Abstract: Artemis (DCLRE1C) is involved in opening recombination-activating gene (RAG1/RAG2)-generated hairpins during V(D)J recombination, an essential process for the differentiation and maturation of T and B cells. Here, we reported a case of 5-month-old boy with… read more here.
Keywords: versus host; combined immunodeficiency; host disease; compound heterozygous ... See more keywords
High lymphocyte counts before antithymocyte globulin administration predict acute graft-versus-host disease
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DOI: 10.1007/s00277-020-04347-1
Abstract: Antithymocyte globulin (ATG) reduces severe acute and chronic graft-versus-host disease (GVHD) in allogeneic peripheral blood stem cell transplantation (PBSCT). However, risk factors for severe acute GVHD in PBSCT using ATG remain to be determined. We… read more here.
Keywords: lymphocyte counts; alc atg; versus host; host disease ... See more keywords