Transition to Oral Antibiotic Therapy for Hospitalized Adults With Gram-Negative Bloodstream Infections
Sign Up to like & getrecommendations! Published in 2024 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2023.49864
Abstract: Key Points Question What is the timeline of transition from intravenous (IV) to oral antibiotics among patients with gram-negative bloodstream infections (GN-BSIs)? Findings In this cohort study of 4581 GN-BSI episodes at 24 US hospitals,… read more here.
Keywords: gram negative; therapy; negative bloodstream; bloodstream infections ... See more keywords
Structural insights into the mechanism of a novel protein targeting pathway in Gram‐negative bacteria
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12813
Abstract: Many nascent polypeptides synthesized in the cytoplasm are translocated across membranes via a specific ‘translocon’ composed of protein complexes. Recently, a novel targeting pathway for the outer membrane β‐barrel proteins (OMPs) in Gram‐negative bacteria was… read more here.
Keywords: protein; mechanism; gram negative; negative bacteria ... See more keywords
Bacterial Outer Membrane‐Coated Mesoporous Silica Nanoparticles for Targeted Delivery of Antibiotic Rifampicin against Gram‐Negative Bacterial Infection In Vivo
Sign Up to like & getrecommendations! Published in 2021 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202103442
Abstract: The efficacy of conventional antibiotics therapeutics has declined rapidly due to the emerged antibiotic resistance. There is an urgent need to develop novel approaches to address the problem of antibiotic shortage, particularly for Gram‐negative bacteria.… read more here.
Keywords: msn omv; rifampicin; outer membrane; gram ... See more keywords
Enhanced Nitric Oxide Delivery Through Self‐Assembling Nanoparticles for Eradicating Gram‐Negative Bacteria
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202403046
Abstract: In the current battle against antibiotic resistance, the resilience of Gram‐negative bacteria against traditional antibiotics is due not only to their protective outer membranes but also to mechanisms like efflux pumps and enzymatic degradation of… read more here.
Keywords: gram negative; delivery; negative bacteria; nitric oxide ... See more keywords
Reaction‐Induced Self‐Assembly of Polymyxin Mitigates Cytotoxicity and Reverses Drug Resistance
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DOI: 10.1002/adma.202406156
Abstract: Polymyxins have been regarded as an efficient therapeutic against many life‐threatening, multidrug resistant Gram‐negative bacterial infections; however, the cytotoxicity and emergence of drug resistance associated with polymyxins have greatly hindered their clinical potential. Herein, the… read more here.
Keywords: resistance; reaction induced; gram negative; induced self ... See more keywords
Exploration of the structure–activity relationship and druggability of novel oxazolidinone‐based compounds as Gram‐negative antibacterial agents
Sign Up to like & getrecommendations! Published in 2019 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.201900129
Abstract: To gain further knowledge of the structure–activity relationship and druggability of novel oxazolidinone‐based UDP‐3‐O‐acyl‐N‐acetylglucosamine deacetylase (LpxC) inhibitors as Gram‐negative antibacterial agents, compounds containing the hydrophobic tails with different lengths and terminal substitutions were synthesized and… read more here.
Keywords: gram negative; structure activity; novel oxazolidinone; oxazolidinone based ... See more keywords
How bacterial cell division might cheat turgor pressure – a unified mechanism of septal division in Gram‐positive and Gram‐negative bacteria
Sign Up to like & getrecommendations! Published in 2017 at "BioEssays"
DOI: 10.1002/bies.201700045
Abstract: An important question for bacterial cell division is how the invaginating septum can overcome the turgor force generated by the high osmolarity of the cytoplasm. I suggest that it may not need to. Several studies… read more here.
Keywords: gram positive; gram; gram negative; division ... See more keywords
Expanding the Spectrum: Modified Bacteriocin Nisin as a Trojan Horse Against Gram‐Negative Salmonella Typhimurium and Escherichia coli
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DOI: 10.1002/biot.70019
Abstract: Nisin is an antimicrobial peptide widely used as a biopreservative to extend shelf life and control foodborne pathogens, particularly Gram‐positive bacteria such as Listeria monocytogenes. However, its efficacy against Gram‐negative bacteria is limited due to… read more here.
Keywords: gram negative; spectrum; coli; typhimurium escherichia ... See more keywords
Motuporamine Derivatives as Antimicrobial Agents and Antibiotic Enhancers against Resistant Gram‐Negative Bacteria
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DOI: 10.1002/cbic.201600532
Abstract: Dihydromotuporamine C and its derivatives were evaluated for their in vitro antimicrobial activities and antibiotic enhancement properties against Gram‐negative bacteria and clinical isolates. The mechanism of action of one of these derivatives, MOTU‐N44, was investigated against… read more here.
Keywords: motuporamine derivatives; agents antibiotic; antimicrobial agents; gram negative ... See more keywords
Identification of a 2‐Aminobenzimidazole Scaffold that Potentiates Gram‐Positive Selective Antibiotics Against Gram‐Negative Bacteria
Sign Up to like & getrecommendations! Published in 2024 at "ChemBioChem"
DOI: 10.1002/cbic.202400127
Abstract: The development of novel therapeutic approaches is crucial in the fight against multi‐drug resistant (MDR) bacteria, particularly gram‐negative species. Small molecule adjuvants that enhance the activity of otherwise gram‐positive selective antibiotics against gram‐negative bacteria have… read more here.
Keywords: gram negative; positive selective; gram positive; selective antibiotics ... See more keywords
Reliability of a Screening Method Using Antibiotic Disks to Detect Carbapenemases in Glucose‐Nonfermenting Gram‐Negative Microorganisms From Clinical Samples of a Regional Hospital in Southeastern Spain
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.25036
Abstract: Infections by glucose‐nonfermenting gram‐negative bacilli (NFGNB) pose a major public health problem due to multiresistance to beta‐lactam antibiotics, especially plasmid‐borne carbapenemases. Their detection by microbiology laboratories is challenging, and there is a need for easy‐to‐use… read more here.
Keywords: gram negative; screening method; nonfermenting gram; detect carbapenemases ... See more keywords