An AIEgen as an Intrinsic Antibacterial Agent for Light-Up Detection and Inactivation of Intracellular Gram-Positive Bacteria.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202100885
Abstract: Infections caused by Gram-positive bacteria, especially those able to invade and survive in host cells, threaten human health severely. It is therefore highly desirable to develop therapeutics that can selectively target and kill intracellular Gram-positive… read more here.
Keywords: intracellular gram; gram positive; positive bacteria; tpepy ... See more keywords
Construction of Rhodamine‐Based AIE Photosensitizer Hydrogel with Clinical Potential for Selective Ablation of Drug‐Resistant Gram‐Positive Bacteria In Vivo
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DOI: 10.1002/adhm.202200837
Abstract: The emergence of powerful antibiotic‐resistant bacteria caused by the abuse of antibiotics has become a public health problem. Photodynamic antibacterial therapy is regarded as an innovative and promising antibacterial approach due to its minor side… read more here.
Keywords: rhodamine based; positive bacteria; photosensitizer; gram positive ... See more keywords
Exploration of (3‐benzyl‐5‐hydroxyphenyl)carbamates as new antibacterial agents against Gram‐positive bacteria
Sign Up to like & getrecommendations! Published in 2020 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.201900294
Abstract: A series of (3‐benzyl‐5‐hydroxyphenyl)carbamates were evaluated as new antibacterial agents. Several compounds showed potent inhibitory activity against sensitive and drug‐resistant Gram‐positive bacteria. The compounds are ineffective against all tested Gram‐negative bacteria. The structure of the… read more here.
Keywords: new antibacterial; gram positive; hydroxyphenyl carbamates; positive bacteria ... See more keywords
How bacterial cell division might cheat turgor pressure – a unified mechanism of septal division in Gram‐positive and Gram‐negative bacteria
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DOI: 10.1002/bies.201700045
Abstract: An important question for bacterial cell division is how the invaginating septum can overcome the turgor force generated by the high osmolarity of the cytoplasm. I suggest that it may not need to. Several studies… read more here.
Keywords: gram positive; gram; gram negative; division ... See more keywords
Intramolecular Covalent Bonds in Gram‐Positive Bacterial Surface Proteins
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DOI: 10.1002/cbic.202200316
Abstract: Gram‐positive bacteria experience considerable mechanical perturbation when adhering to host surfaces during colonization and infection. They have evolved various adhesion proteins that are mechanically robust to ensure strong surface adhesion. Recently, it was discovered that… read more here.
Keywords: surface; covalent bonds; intramolecular covalent; positive bacterial ... See more keywords
Semisynthetic Vitamin E Derivatives as Potent Antibacterial Agents against Resistant Gram‐Positive Pathogens
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DOI: 10.1002/cmdc.202000792
Abstract: New 5‐substituted vitamin E derivatives were semisynthesized, and their antibacterial activity against human Gram‐positive and Gram‐negative pathogens was evaluated. Several vitamin E analogues were active against methicillin‐resistant Staphylococcus aureus (MRSA) and/or methicillin‐resistant Staphylococcus epidermidis (MRSE);… read more here.
Keywords: gram positive; gram; derivatives potent; vitamin ... See more keywords
Thieno[2,3‐d]pyrimidine‐Core Compounds Show Activity against Clinically Relevant Gram‐Positive Bacteria
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DOI: 10.1002/cmdc.202200207
Abstract: Thieno[2,3‐d]pyrimidines represent a novel antibacterial prodrug scaffold, previously identified through a screening campaign against Mycobacterium tuberculosis in which the formation of highly antimycobacterial metabolites catalyzed by the nitroreductase Mrx2 is suggested to be the relevant… read more here.
Keywords: thieno pyrimidine; pyrimidine core; activity; core compounds ... See more keywords
TLR8 and complement C5 induce cytokine release and thrombin activation in human whole blood challenged with Gram‐positive bacteria
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3a0120-114r
Abstract: We recently showed that TLR8 is critical for the detection of Gram‐positive bacteria by human monocytes. Here, we hypothesized that TLR8 and complement together regulate antibacterial responses in human blood. Anticoagulated blood was treated with… read more here.
Keywords: activation; tlr8 complement; blood; positive bacteria ... See more keywords
Spatial Organization of Cell Wall-Anchored Proteins at the Surface of Gram-Positive Bacteria.
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DOI: 10.1007/82_2016_4
Abstract: Bacterial surface proteins constitute an amazing repertoire of molecules with important functions such as adherence, invasion, signalling and interaction with the host immune system or environment. In Gram-positive bacteria, many surface proteins of the "LPxTG"… read more here.
Keywords: gram positive; wall anchored; anchored proteins; cell wall ... See more keywords
Membrane Proteomics in Gram-Positive Bacteria: Two Complementary Approaches to Target the Hydrophobic Species of Proteins.
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DOI: 10.1007/978-1-4939-8695-8_3
Abstract: This protocol represents a detailed instruction how to prepare protein samples in order to raise mass spectrometry-based identification and quantification rates with respect to the challenging class of membrane proteins. This will increase comprehensiveness of… read more here.
Keywords: protein; gram positive; membrane proteins; proteins membrane ... See more keywords
Overview on the role of heavy metals tolerance on developing antibiotic resistance in both Gram-negative and Gram-positive bacteria.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of microbiology"
DOI: 10.1007/s00203-021-02275-w
Abstract: Environmental health is a critical concern, continuously contaminated by physical and biological components (viz., anthropogenic activity), which adversely affect on biodiversity, ecosystems and human health. Nonetheless, environmental pollution has great impact on microbial communities, especially… read more here.
Keywords: gram positive; positive bacteria; resistance; heavy metals ... See more keywords