D‐cysteine‐Derived Carbon Dots for Selective Discrimination, Imaging, and Synergistic Elimination of Gram‐Positive Bacteria and Fungi
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202402761
Abstract: Microbial infections pose a significant threat to public health, exacerbated by the escalating issue of antibiotic resistance resulting from their overuse. Chiral carbon dots (CDs) not only inherit the antibacterial properties of CDs but also… read more here.
Keywords: bacteria fungi; gram positive; carbon dots; positive bacteria ... See more keywords
An AIEgen as an Intrinsic Antibacterial Agent for Light-Up Detection and Inactivation of Intracellular Gram-Positive Bacteria.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202100885
Abstract: Infections caused by Gram-positive bacteria, especially those able to invade and survive in host cells, threaten human health severely. It is therefore highly desirable to develop therapeutics that can selectively target and kill intracellular Gram-positive… read more here.
Keywords: intracellular gram; gram positive; positive bacteria; tpepy ... See more keywords
Construction of Rhodamine‐Based AIE Photosensitizer Hydrogel with Clinical Potential for Selective Ablation of Drug‐Resistant Gram‐Positive Bacteria In Vivo
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202200837
Abstract: The emergence of powerful antibiotic‐resistant bacteria caused by the abuse of antibiotics has become a public health problem. Photodynamic antibacterial therapy is regarded as an innovative and promising antibacterial approach due to its minor side… read more here.
Keywords: rhodamine based; positive bacteria; photosensitizer; gram positive ... See more keywords
Exploration of (3‐benzyl‐5‐hydroxyphenyl)carbamates as new antibacterial agents against Gram‐positive bacteria
Sign Up to like & getrecommendations! Published in 2020 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.201900294
Abstract: A series of (3‐benzyl‐5‐hydroxyphenyl)carbamates were evaluated as new antibacterial agents. Several compounds showed potent inhibitory activity against sensitive and drug‐resistant Gram‐positive bacteria. The compounds are ineffective against all tested Gram‐negative bacteria. The structure of the… read more here.
Keywords: new antibacterial; gram positive; hydroxyphenyl carbamates; positive bacteria ... See more keywords
How bacterial cell division might cheat turgor pressure – a unified mechanism of septal division in Gram‐positive and Gram‐negative bacteria
Sign Up to like & getrecommendations! Published in 2017 at "BioEssays"
DOI: 10.1002/bies.201700045
Abstract: An important question for bacterial cell division is how the invaginating septum can overcome the turgor force generated by the high osmolarity of the cytoplasm. I suggest that it may not need to. Several studies… read more here.
Keywords: gram positive; gram; gram negative; division ... See more keywords
Intramolecular Covalent Bonds in Gram‐Positive Bacterial Surface Proteins
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DOI: 10.1002/cbic.202200316
Abstract: Gram‐positive bacteria experience considerable mechanical perturbation when adhering to host surfaces during colonization and infection. They have evolved various adhesion proteins that are mechanically robust to ensure strong surface adhesion. Recently, it was discovered that… read more here.
Keywords: surface; covalent bonds; intramolecular covalent; positive bacterial ... See more keywords
Identification of a 2‐Aminobenzimidazole Scaffold that Potentiates Gram‐Positive Selective Antibiotics Against Gram‐Negative Bacteria
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DOI: 10.1002/cbic.202400127
Abstract: The development of novel therapeutic approaches is crucial in the fight against multi‐drug resistant (MDR) bacteria, particularly gram‐negative species. Small molecule adjuvants that enhance the activity of otherwise gram‐positive selective antibiotics against gram‐negative bacteria have… read more here.
Keywords: gram negative; positive selective; gram positive; selective antibiotics ... See more keywords
Semisynthetic Vitamin E Derivatives as Potent Antibacterial Agents against Resistant Gram‐Positive Pathogens
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DOI: 10.1002/cmdc.202000792
Abstract: New 5‐substituted vitamin E derivatives were semisynthesized, and their antibacterial activity against human Gram‐positive and Gram‐negative pathogens was evaluated. Several vitamin E analogues were active against methicillin‐resistant Staphylococcus aureus (MRSA) and/or methicillin‐resistant Staphylococcus epidermidis (MRSE);… read more here.
Keywords: gram positive; gram; derivatives potent; vitamin ... See more keywords
Thieno[2,3‐d]pyrimidine‐Core Compounds Show Activity against Clinically Relevant Gram‐Positive Bacteria
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DOI: 10.1002/cmdc.202200207
Abstract: Thieno[2,3‐d]pyrimidines represent a novel antibacterial prodrug scaffold, previously identified through a screening campaign against Mycobacterium tuberculosis in which the formation of highly antimycobacterial metabolites catalyzed by the nitroreductase Mrx2 is suggested to be the relevant… read more here.
Keywords: thieno pyrimidine; pyrimidine core; activity; core compounds ... See more keywords
TLR8 and complement C5 induce cytokine release and thrombin activation in human whole blood challenged with Gram‐positive bacteria
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3a0120-114r
Abstract: We recently showed that TLR8 is critical for the detection of Gram‐positive bacteria by human monocytes. Here, we hypothesized that TLR8 and complement together regulate antibacterial responses in human blood. Anticoagulated blood was treated with… read more here.
Keywords: activation; tlr8 complement; blood; positive bacteria ... See more keywords
Spatial Organization of Cell Wall-Anchored Proteins at the Surface of Gram-Positive Bacteria.
Sign Up to like & getrecommendations! Published in 2017 at "Current topics in microbiology and immunology"
DOI: 10.1007/82_2016_4
Abstract: Bacterial surface proteins constitute an amazing repertoire of molecules with important functions such as adherence, invasion, signalling and interaction with the host immune system or environment. In Gram-positive bacteria, many surface proteins of the "LPxTG"… read more here.
Keywords: gram positive; wall anchored; anchored proteins; cell wall ... See more keywords