LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "gramicidin" as a keyword



Exploring the Substrate Flexibility of GrsB Thioesterase Leads to the Structural Reassignment of a Gramicidin S Variant

Sign Up to like & get
recommendations! Published in 2025 at "Chembiochem"

DOI: 10.1002/cbic.202500412

Abstract: Gramicidin S (GS) is a cyclic decapeptide derived from two pentapeptides. The C‐terminal thioesterase (TE) domain of gramicidin S synthetase B (GrsB) dimerizes precursor pentapeptides and cyclizes the resulting linear decapeptide. Recently, a GS variant… read more here.

Keywords: grsb; ser allyl; gramicidin; thioesterase ... See more keywords

Investigation of structural stability and functionality of homodimeric gramicidin towards peptide‐based drug: a molecular simulation approach

Sign Up to like & get
recommendations! Published in 2019 at "Journal of Cellular Biochemistry"

DOI: 10.1002/jcb.27765

Abstract: Increasing death rates due to antibiotic resistance deteriorate the existing treatment measures. Antimicrobial peptides have turned into the emerging cure for multidrug resistance. However, the stability and functionality determine an antimicrobial peptide as a drug.… read more here.

Keywords: drug; stability functionality; gramicidin; structural stability ... See more keywords

Molecular Mechanism for Gramicidin Dimerization and Dissociation in Bilayers of Different Thickness

Sign Up to like & get
recommendations! Published in 2019 at "Biophysical Journal"

DOI: 10.1016/j.bpj.2019.09.044

Abstract: Membrane protein functions can be altered by subtle changes in the host lipid bilayer physical properties. Gramicidin channels have emerged as a powerful system for elucidating the underlying mechanisms of membrane protein function regulation through… read more here.

Keywords: gramicidin; mechanism; bilayer; bilayers different ... See more keywords

Machine-Learning Approach to Increase the Potency and Overcome the Hemolytic Toxicity of Gramicidin S.

Sign Up to like & get
recommendations! Published in 2025 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.5c01054

Abstract: Antibiotic resistance is a global health crisis, with multidrug-resistant pathogens like methicillin-resistant Staphylococcus aureus (MRSA) demanding next-generation therapeutics. Tackling this silent pandemic requires innovative strategies beyond traditional drug discovery. We present a machine-learning (ML)-driven computational… read more here.

Keywords: increase potency; potency; machine learning; hemolytic toxicity ... See more keywords

Memristive plasticity in artificial electrical synapses via geometrically reconfigurable, gramicidin-doped biomembranes.

Sign Up to like & get
recommendations! Published in 2019 at "Nanoscale"

DOI: 10.1039/c9nr07288h

Abstract: It is now known that mammalian brains leverage plasticity of both chemical and electrical synapses (ES) for collocating memory and processing. Unlike chemical synapses, ES join neurons via gap junction ion channels that permit fast,… read more here.

Keywords: gramicidin; artificial electrical; conductance; ion ... See more keywords

Cholesterol-induced deformation of the gramicidin-A channel inhibiting potassium ion binding and transport

Sign Up to like & get
recommendations! Published in 2024 at "Chinese Physics B"

DOI: 10.1088/1674-1056/ad334e

Abstract: Gramicidin A (gA) is a kind of antibiotic peptide produced by bacillus brevis and it can dimerize across lipid bilayers to form a monovalent cation channel. In this work, we investigate the impact of cholesterol… read more here.

Keywords: ion binding; transport; cholesterol; channel ... See more keywords

New role of gramicidin A in RIG‐I‐like receptors‐mediated IFN signalling

Sign Up to like & get
recommendations! Published in 2023 at "Immunology"

DOI: 10.1111/imm.13626

Abstract: The pattern recognition receptors (PRRs) sense exogenous molecular patterns most commonly derived from invading pathogens, to active the interferon (IFN) signalling. In the cytoplasm, the viral double‐stranded RNAs (dsRNAs) are sensed by retinoic acid‐inducible gene… read more here.

Keywords: mediated ifn; new role; ifn signalling; role gramicidin ... See more keywords

Gramicidin inhibits human gastric cancer cell proliferation, cell cycle and induced apoptosis

Sign Up to like & get
recommendations! Published in 2019 at "Biological Research"

DOI: 10.1186/s40659-019-0264-1

Abstract: BackgroundGastric cancer is a common malignant tumor with high morbidity and mortality worldwide, which seriously affects human health. Gramicidin is a short peptide antibiotic which could be used for treating infection induced by bacteria or… read more here.

Keywords: gramicidin; gastric cancer; cell cycle; cancer cells ... See more keywords

Effects of Calcium Ions on the Antimicrobial Activity of Gramicidin A

Sign Up to like & get
recommendations! Published in 2022 at "Biomolecules"

DOI: 10.3390/biom12121799

Abstract: Gramicidin A (gA) is a linear antimicrobial peptide that can form a channel and specifically conduct monovalent cations such as H+ across the lipid membrane. The antimicrobial activity of gA is associated with the formation… read more here.

Keywords: ca2 ions; gramicidin; antimicrobial activity; ions antimicrobial ... See more keywords