Investigation of structural stability and functionality of homodimeric gramicidin towards peptide‐based drug: a molecular simulation approach
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27765
Abstract: Increasing death rates due to antibiotic resistance deteriorate the existing treatment measures. Antimicrobial peptides have turned into the emerging cure for multidrug resistance. However, the stability and functionality determine an antimicrobial peptide as a drug.… read more here.
Keywords: drug; stability functionality; gramicidin; structural stability ... See more keywords
Molecular Mechanism for Gramicidin Dimerization and Dissociation in Bilayers of Different Thickness
Sign Up to like & getrecommendations! Published in 2019 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2019.09.044
Abstract: Membrane protein functions can be altered by subtle changes in the host lipid bilayer physical properties. Gramicidin channels have emerged as a powerful system for elucidating the underlying mechanisms of membrane protein function regulation through… read more here.
Keywords: gramicidin; mechanism; bilayer; bilayers different ... See more keywords
Memristive plasticity in artificial electrical synapses via geometrically reconfigurable, gramicidin-doped biomembranes.
Sign Up to like & getrecommendations! Published in 2019 at "Nanoscale"
DOI: 10.1039/c9nr07288h
Abstract: It is now known that mammalian brains leverage plasticity of both chemical and electrical synapses (ES) for collocating memory and processing. Unlike chemical synapses, ES join neurons via gap junction ion channels that permit fast,… read more here.
Keywords: gramicidin; artificial electrical; conductance; ion ... See more keywords
New role of gramicidin A in RIG‐I‐like receptors‐mediated IFN signalling
Sign Up to like & getrecommendations! Published in 2023 at "Immunology"
DOI: 10.1111/imm.13626
Abstract: The pattern recognition receptors (PRRs) sense exogenous molecular patterns most commonly derived from invading pathogens, to active the interferon (IFN) signalling. In the cytoplasm, the viral double‐stranded RNAs (dsRNAs) are sensed by retinoic acid‐inducible gene… read more here.
Keywords: mediated ifn; new role; ifn signalling; role gramicidin ... See more keywords
Gramicidin inhibits human gastric cancer cell proliferation, cell cycle and induced apoptosis
Sign Up to like & getrecommendations! Published in 2019 at "Biological Research"
DOI: 10.1186/s40659-019-0264-1
Abstract: BackgroundGastric cancer is a common malignant tumor with high morbidity and mortality worldwide, which seriously affects human health. Gramicidin is a short peptide antibiotic which could be used for treating infection induced by bacteria or… read more here.
Keywords: gramicidin; gastric cancer; cell cycle; cancer cells ... See more keywords
Effects of Calcium Ions on the Antimicrobial Activity of Gramicidin A
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12121799
Abstract: Gramicidin A (gA) is a linear antimicrobial peptide that can form a channel and specifically conduct monovalent cations such as H+ across the lipid membrane. The antimicrobial activity of gA is associated with the formation… read more here.
Keywords: ca2 ions; gramicidin; antimicrobial activity; ions antimicrobial ... See more keywords