Large granular lymphocyte leukemia serum and corresponding hematological parameters reveal unique cytokine and sphingolipid biomarkers and associations with STAT3 mutations
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Medicine"
DOI: 10.1002/cam4.3246
Abstract: Large granular lymphocyte (LGL) leukemia is a rare hematological disorder with expansion of the T‐cell or natural killer (NK) cell lineage. Signal transducer and activator of transcription 3 (STAT3) exhibits somatic activating mutations in 30%‐40%… read more here.
Keywords: stat3 mutations; granular lymphocyte; large granular; serum ... See more keywords
Genomic landscape characterization of large granular lymphocyte leukemia with a systems genetics approach
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DOI: 10.1038/leu.2017.49
Abstract: Genomic landscape characterization of large granular lymphocyte leukemia with a systems genetics approach read more here.
Keywords: characterization large; genetics; granular lymphocyte; large granular ... See more keywords
STAT3 activation in large granular lymphocyte leukemia is associated with cytokine signaling and DNA hypermethylation
Sign Up to like & getrecommendations! Published in 2021 at "Leukemia"
DOI: 10.1038/s41375-021-01296-0
Abstract: Large granular lymphocyte leukemia (LGLL) is characterized by somatic gain-of-function STAT3 mutations. However, the functional effects of STAT3 mutations on primary LGLL cells have not been studied in detail. In this study, we show that… read more here.
Keywords: hypermethylation; granular lymphocyte; large granular; stat3 ... See more keywords
The spectrum of somatic mutations in large granular lymphocyte leukemia, rheumatoid arthritis, and Felty's syndrome.
Sign Up to like & getrecommendations! Published in 2022 at "Seminars in hematology"
DOI: 10.1053/j.seminhematol.2022.07.004
Abstract: T cell large granular lymphocyte leukemia (T-LGLL) is an interesting case at the intersection of autoimmunity and cancer. In T-LGLL, T cells with somatic pathogenic mutations (mainly in STAT3) are linked to rheumatoid arthritis (RA)… read more here.
Keywords: felty syndrome; somatic mutations; granular lymphocyte; large granular ... See more keywords
CD8‐positive cutaneous lymphoproliferation associated with large granular lymphocyte leukemia in a patient with X‐linked agammaglobulinemia
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cutaneous Pathology"
DOI: 10.1111/cup.13860
Abstract: Patients with primary immunodeficiency are at increased risk for malignancy, especially hematologic neoplasms. This paper reports a unique case of a 47‐year‐old man with X‐linked agammaglobulinemia who presented with progressive asymptomatic violaceous papules and plaques… read more here.
Keywords: linked agammaglobulinemia; granular lymphocyte; large granular; cd8 positive ... See more keywords
Feline large granular lymphocyte lymphoma: An Italian Society of Veterinary Oncology (SIONCOV) retrospective study
Sign Up to like & getrecommendations! Published in 2018 at "Veterinary and Comparative Oncology"
DOI: 10.1111/vco.12325
Abstract: Feline large granular lymphocyte (LGL) lymphoma is an uncommon subtype of lymphoma characterized by a grave prognosis and scarce response to chemotherapy. There are limited reports on clinico-pathological and prognostic factors. One-hundred and 9 cats… read more here.
Keywords: biochemistry; lymphoma; feline large; granular lymphocyte ... See more keywords
Genomic Landscape of TCR Alpha-Beta and TCR Gamma-Delta T-Large Granular Lymphocyte Leukemia.
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DOI: 10.1182/blood.2021013164
Abstract: Large granular lymphocyte (LGL) leukemia comprises a group of rare lymphoproliferative disorders whose molecular landscape is incompletely defined. We leveraged paired whole exome and transcriptome sequencing in the largest LGL leukemia cohort to date, which… read more here.
Keywords: tcr; granular lymphocyte; leukemia; large granular ... See more keywords
Therapeutic Efficacy of Mcl-1 Antagonism in Large Granular Lymphocyte Leukemia
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DOI: 10.1182/blood.v130.suppl_1.1217.1217
Abstract: Introduction: Large granular lymphocyte (LGL) leukemia is a spectrum of rare clonal lymphoproliferative disorders, all of which involve expansion of large granular lymphocytes. Immunosuppressive regimens using methotrexate or cyclophosphamide are utilized as front-line treatments in… read more here.
Keywords: mcl; granular lymphocyte; large granular; lgl leukemia ... See more keywords
Identification of a miR-146b-Fas ligand axis in the development of neutropenia in T large granular lymphocyte leukemia
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DOI: 10.3324/haematol.2019.225060
Abstract: Tlarge granular lymphocyte leukemia (T-LGLL) is characterized by the expansion of several large granular lymphocyte clones, among which a subset of large granular lymphocytes showing constitutively activated STAT3, a specific CD8+/CD4− phenotype and the presence… read more here.
Keywords: granular lymphocyte; large granular; expression; mir 146b ... See more keywords
Intersection Between Large Granular Lymphocyte Leukemia and Rheumatoid Arthritis
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DOI: 10.3389/fonc.2022.869205
Abstract: Large granular lymphocyte (LGL) leukemia, a rare hematologic malignancy, has long been associated with rheumatoid arthritis (RA), and the diseases share numerous common features. This review aims to outline the parallels and comparisons between the… read more here.
Keywords: granular lymphocyte; leukemia; rheumatoid arthritis; lgl leukemia ... See more keywords
Persistent Large Granular Lymphocyte Clonal Expansions: “The Root of Many Evils”—And of Some Goodness
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DOI: 10.3390/cancers14051340
Abstract: Simple Summary Large granular lymphocyte leukemia (LGLL) is a chronic disorder of either mature T or NK lymphocytes. As clonal expansions of the immune system cells, difficulties in the distinction between a true neoplasia and… read more here.
Keywords: clonal expansions; granular lymphocyte; persistent large; large granular ... See more keywords