Loss of tumor necrosis factor (TNF)‐receptor 1 and TNF‐receptor 2 partially replicate effects of TNF deficiency on dendritic spines of granule cells in mouse dentate gyrus
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.25424
Abstract: The cytokine tumor necrosis factor (TNF) is involved in the regulation of physiological and pathophysiological processes in the central nervous system. In previous work, we showed that mice lacking constitutive levels of TNF exhibit a… read more here.
Keywords: tnf receptor; tnf; granule; granule cells ... See more keywords
Granule cell dispersion in two mouse models of temporal lobe epilepsy and reeler mice is associated with changes in dendritic orientation and spine distribution
Sign Up to like & getrecommendations! Published in 2022 at "Hippocampus"
DOI: 10.1002/hipo.23447
Abstract: Temporal lobe epilepsy is characterized by hippocampal neuronal death in CA1 and hilus. Dentate gyrus granule cells survive but show dispersion of the compact granule cell layer. This is associated with decrease of the glycoprotein… read more here.
Keywords: granule cell; granule; reeler mice; mice ... See more keywords
Global characterization of chemical compounds in Shidan granule and their metabolites in rat plasma using ultra-high-performance liquid chromatography coupled with quadrupole-time of flight mass spectrometry.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of separation science"
DOI: 10.1002/jssc.202200391
Abstract: Shidan granule is an in-hospital traditional Chinese medicines prescription with obvious clinical effect in the treatment of chronic atrophic gastritis. Charactering the compounds of Shidan granule and exploring the absorbed prototype constituents and metabolites in… read more here.
Keywords: compounds shidan; ultra high; rat plasma; shidan granule ... See more keywords
Endocytosis is required for exocytosis and priming of respiratory burst activity in human neutrophils
Sign Up to like & getrecommendations! Published in 2017 at "Inflammation Research"
DOI: 10.1007/s00011-017-1070-2
Abstract: Objective and designNeutrophil generation of reactive oxygen species (ROS) is enhanced by exposure to pro-inflammatory agents in a process termed priming. Priming is depending on exocytosis of neutrophil granules and p47phox phosphorylation-dependent translocation of cytosolic… read more here.
Keywords: priming respiratory; endocytosis; human neutrophils; exocytosis ... See more keywords
Non-radial tortuous migration with cell polarity alterations of newly generated granule neurons in the neonatal rat dentate gyrus
Sign Up to like & getrecommendations! Published in 2019 at "Brain Structure and Function"
DOI: 10.1007/s00429-019-01971-0
Abstract: To establish functional neuronal circuits, newborn neurons generally migrate from the ventricular germinal zones to their final positions during embryonic periods. However, most excitatory neurons of the hippocampal dentate gyrus are born postnatally in the… read more here.
Keywords: newly generated; dentate gyrus; generated granule; cell ... See more keywords
The Joubert Syndrome Gene arl13b is Critical for Early Cerebellar Development in Zebrafish
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience Bulletin"
DOI: 10.1007/s12264-020-00554-y
Abstract: Joubert syndrome is characterized by unique malformation of the cerebellar vermis. More than thirty Joubert syndrome genes have been identified, including ARL13B. However, its role in cerebellar development remains unexplored. We found that knockdown or… read more here.
Keywords: early cerebellar; joubert syndrome; cerebellar development; cerebellar ... See more keywords
Different Molecular Mechanisms Mediate Direct or Glia-Dependent Prion Protein Fragment 90–231 Neurotoxic Effects in Cerebellar Granule Neurons
Sign Up to like & getrecommendations! Published in 2017 at "Neurotoxicity Research"
DOI: 10.1007/s12640-017-9749-2
Abstract: Glia over-stimulation associates with amyloid deposition contributing to the progression of central nervous system neurodegenerative disorders. Here we analyze the molecular mechanisms mediating microglia-dependent neurotoxicity induced by prion protein (PrP)90–231, an amyloidogenic polypeptide corresponding to… read more here.
Keywords: cerebellar granule; prp90 231; prion protein; neurotoxicity ... See more keywords
Dependencies between internal structure and mechanical properties of spray dried granules – Experimental study and DEM simulation
Sign Up to like & getrecommendations! Published in 2017 at "Advanced Powder Technology"
DOI: 10.1016/j.apt.2016.09.008
Abstract: Abstract The mechanical properties of spray dried granules are decisive with regard to further applications and can be modified via internal granule structure. To obtain the correlations between structural and mechanical properties, necessary experiments are… read more here.
Keywords: properties spray; mechanical properties; spray dried; structure ... See more keywords
Computational modeling offers new insight into Drosophila germ granule development.
Sign Up to like & getrecommendations! Published in 2022 at "Biophysical journal"
DOI: 10.1016/j.bpj.2022.03.014
Abstract: The packaging of specific mRNAs into ribonucleoprotein granules called germ granules is required for germline proliferation and maintenance. During Drosophila germ granule development, mRNAs such as nanos (nos) and polar granule component (pgc) localize to… read more here.
Keywords: granule development; germ granule; drosophila germ; granule ... See more keywords
Structural disorganization of cereal, tuber and bean starches in aqueous ionic liquid at room temperature: Role of starch granule surface structure.
Sign Up to like & getrecommendations! Published in 2021 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2021.117677
Abstract: The structural disorganization of different starches in a 1-ethyl-3-methylimidazolium acetate ([Emim][OAc])/water mixture (1:6 mol./mol.) at room temperature (25 °C) was studied. For normal cereal starches, which have pinholes randomly dispersed on the granule surface or… read more here.
Keywords: disorganization; surface; room temperature; structural disorganization ... See more keywords
Sparsification of AP firing in adult-born hippocampal granule cells via voltage-dependent α5-GABAA receptors.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109768
Abstract: GABA can depolarize immature neurons close to the action potential (AP) threshold in development and adult neurogenesis. Nevertheless, GABAergic synapses effectively inhibit AP firing in newborn granule cells of the adult hippocampus as early as… read more here.
Keywords: adult; hippocampal granule; voltage dependent; gabaa receptors ... See more keywords