LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "granule cell" as a keyword



Photo by adam_skrinnikoff from unsplash

Seizure severity‐dependent selective vulnerability of the granule cell layer and aberrant neurogenesis in the rat hippocampus

Sign Up to like & get
recommendations! Published in 2017 at "Hippocampus"

DOI: 10.1002/hipo.22752

Abstract: The pilocarpine‐induced status epilepticus rodent model has been commonly used to analyze the mechanisms of human temporal lobe epilepsy. Recent studies using this model have demonstrated that epileptic seizures lead to increased adult neurogenesis of… read more here.

Keywords: granule cell; hippocampus; neurogenesis; layer ... See more keywords

Granule cell dispersion in two mouse models of temporal lobe epilepsy and reeler mice is associated with changes in dendritic orientation and spine distribution

Sign Up to like & get
recommendations! Published in 2022 at "Hippocampus"

DOI: 10.1002/hipo.23447

Abstract: Temporal lobe epilepsy is characterized by hippocampal neuronal death in CA1 and hilus. Dentate gyrus granule cells survive but show dispersion of the compact granule cell layer. This is associated with decrease of the glycoprotein… read more here.

Keywords: granule cell; granule; reeler mice; mice ... See more keywords

Early-life stress increases granule cell density in the cerebellum of male rats

Sign Up to like & get
recommendations! Published in 2019 at "Brain Research"

DOI: 10.1016/j.brainres.2019.146358

Abstract: In rodents, daily maternal separation for 180 minutes (MS180) during the first weeks of life affects hippocampal granule cell neurogenesis. Development of the cerebellum granule cell layer also occurs during the first weeks of life.… read more here.

Keywords: granule cell; life stress; early life; ms180 ... See more keywords

Preterm birth disrupts cerebellar development by affecting granule cell proliferation program and Bergmann glia

Sign Up to like & get
recommendations! Published in 2018 at "Experimental Neurology"

DOI: 10.1016/j.expneurol.2018.05.015

Abstract: ABSTRACT Preterm birth is a leading cause of long‐term motor and cognitive deficits. Clinical studies suggest that some of these deficits result from disruption of cerebellar development, but the mechanisms that mediate cerebellar abnormalities in… read more here.

Keywords: granule cell; preterm birth; birth; development ... See more keywords

Otx2 promotes granule cell precursor proliferation and Shh-dependent medulloblastoma maintenance in vivo

Sign Up to like & get
recommendations! Published in 2018 at "Oncogenesis"

DOI: 10.1038/s41389-018-0070-6

Abstract: The developmental gene OTX2 is expressed by cerebellar granule cell precursors (GCPs), a cell population which undergoes massive expansion during the early postnatal period in response to sonic hedgehog (Shh). GCPs are thought to be… read more here.

Keywords: granule cell; otx2; proliferation; shh dependent ... See more keywords

The effects of bipolar disorder granule cell hyperexcitability and lithium therapy on pattern separation in a computational model of the dentate gyrus

Sign Up to like & get
recommendations! Published in 2024 at "Translational Psychiatry"

DOI: 10.1038/s41398-025-03559-1

Abstract: Induced pluripotent stem cell (iPSC) derived hippocampal dentate granule cell-like neurons from individuals with bipolar disorder (BD) are hyperexcitable and more spontaneously active relative to healthy control (HC) neurons. These abnormalities are normalised after the… read more here.

Keywords: lithium; granule cell; cell; lithium therapy ... See more keywords

Dynamics and function of CXCR4 in formation of the granule cell layer during hippocampal development

Sign Up to like & get
recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/s41598-017-05738-7

Abstract: In the developing hippocampus, granule cell progenitors (GCPs) arising in the ventricular zone (VZ) migrate to the subpial region, and form the granule cell layer (GCL) of the dentate gyrus (DG). To understand the mechanism… read more here.

Keywords: granule; granule cell; dynamics function; cell layer ... See more keywords

Mitotic granule cell precursors undergo highly dynamic morphological transitions throughout the external germinal layer of the chick cerebellum

Sign Up to like & get
recommendations! Published in 2019 at "Scientific Reports"

DOI: 10.1038/s41598-019-51532-y

Abstract: The developing cerebellum of amniotes is characterised by a unique, transient, secondary proliferation zone: the external germinal layer (EGL). The EGL is comprised solely of granule cell precursors, whose progeny migrate inwardly to form the… read more here.

Keywords: granule cell; cell precursors; layer; cerebellum ... See more keywords

Behavioral decline in Shank3Δex4–22 mice during early adulthood parallels cerebellar granule cell glutamatergic synaptic changes

Sign Up to like & get
recommendations! Published in 2024 at "Molecular Autism"

DOI: 10.1186/s13229-024-00628-y

Abstract: SHANK3, a gene encoding a synaptic scaffolding protein, is implicated in autism spectrum disorder (ASD) and is disrupted in Phelan-McDermid syndrome (PMS). Despite evidence of regression or worsening of ASD-like symptoms in individuals with PMS,… read more here.

Keywords: cerebellar granule; granule cell; shank3 ex4; shank3 ... See more keywords

Progression in Time of Dentate Gyrus Granule Cell Layer Widening due to Excitotoxicity Occurs along In Vivo LTP Reinstatement and Contextual Fear Memory Recovery

Sign Up to like & get
recommendations! Published in 2022 at "Neural Plasticity"

DOI: 10.21203/rs.3.rs-1344273/v1

Abstract: The dentate gyrus (DG) is the gateway of sensory information arriving from the perforant pathway (PP) to the hippocampus. The adequate integration of incoming information into the DG is paramount in the execution of hippocampal-dependent… read more here.

Keywords: contextual fear; gcl widening; fear memory; granule cell ... See more keywords

Considering the Role of Extracellular Matrix Molecules, in Particular Reelin, in Granule Cell Dispersion Related to Temporal Lobe Epilepsy

Sign Up to like & get
recommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"

DOI: 10.3389/fcell.2022.917575

Abstract: The extracellular matrix (ECM) of the nervous system can be considered as a dynamically adaptable compartment between neuronal cells, in particular neurons and glial cells, that participates in physiological functions of the nervous system. It… read more here.

Keywords: extracellular matrix; role; granule cell; reelin ... See more keywords