Seizure severity‐dependent selective vulnerability of the granule cell layer and aberrant neurogenesis in the rat hippocampus
Sign Up to like & getrecommendations! Published in 2017 at "Hippocampus"
DOI: 10.1002/hipo.22752
Abstract: The pilocarpine‐induced status epilepticus rodent model has been commonly used to analyze the mechanisms of human temporal lobe epilepsy. Recent studies using this model have demonstrated that epileptic seizures lead to increased adult neurogenesis of… read more here.
Keywords: granule cell; hippocampus; neurogenesis; layer ... See more keywords
Granule cell dispersion in two mouse models of temporal lobe epilepsy and reeler mice is associated with changes in dendritic orientation and spine distribution
Sign Up to like & getrecommendations! Published in 2022 at "Hippocampus"
DOI: 10.1002/hipo.23447
Abstract: Temporal lobe epilepsy is characterized by hippocampal neuronal death in CA1 and hilus. Dentate gyrus granule cells survive but show dispersion of the compact granule cell layer. This is associated with decrease of the glycoprotein… read more here.
Keywords: granule cell; granule; reeler mice; mice ... See more keywords
Early-life stress increases granule cell density in the cerebellum of male rats
Sign Up to like & getrecommendations! Published in 2019 at "Brain Research"
DOI: 10.1016/j.brainres.2019.146358
Abstract: In rodents, daily maternal separation for 180 minutes (MS180) during the first weeks of life affects hippocampal granule cell neurogenesis. Development of the cerebellum granule cell layer also occurs during the first weeks of life.… read more here.
Keywords: granule cell; life stress; early life; ms180 ... See more keywords
Preterm birth disrupts cerebellar development by affecting granule cell proliferation program and Bergmann glia
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2018.05.015
Abstract: ABSTRACT Preterm birth is a leading cause of long‐term motor and cognitive deficits. Clinical studies suggest that some of these deficits result from disruption of cerebellar development, but the mechanisms that mediate cerebellar abnormalities in… read more here.
Keywords: granule cell; preterm birth; birth; development ... See more keywords
Otx2 promotes granule cell precursor proliferation and Shh-dependent medulloblastoma maintenance in vivo
Sign Up to like & getrecommendations! Published in 2018 at "Oncogenesis"
DOI: 10.1038/s41389-018-0070-6
Abstract: The developmental gene OTX2 is expressed by cerebellar granule cell precursors (GCPs), a cell population which undergoes massive expansion during the early postnatal period in response to sonic hedgehog (Shh). GCPs are thought to be… read more here.
Keywords: granule cell; otx2; proliferation; shh dependent ... See more keywords
Dynamics and function of CXCR4 in formation of the granule cell layer during hippocampal development
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-05738-7
Abstract: In the developing hippocampus, granule cell progenitors (GCPs) arising in the ventricular zone (VZ) migrate to the subpial region, and form the granule cell layer (GCL) of the dentate gyrus (DG). To understand the mechanism… read more here.
Keywords: granule; granule cell; dynamics function; cell layer ... See more keywords
Mitotic granule cell precursors undergo highly dynamic morphological transitions throughout the external germinal layer of the chick cerebellum
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-51532-y
Abstract: The developing cerebellum of amniotes is characterised by a unique, transient, secondary proliferation zone: the external germinal layer (EGL). The EGL is comprised solely of granule cell precursors, whose progeny migrate inwardly to form the… read more here.
Keywords: granule cell; cell precursors; layer; cerebellum ... See more keywords
Progression in Time of Dentate Gyrus Granule Cell Layer Widening due to Excitotoxicity Occurs along In Vivo LTP Reinstatement and Contextual Fear Memory Recovery
Sign Up to like & getrecommendations! Published in 2022 at "Neural Plasticity"
DOI: 10.21203/rs.3.rs-1344273/v1
Abstract: The dentate gyrus (DG) is the gateway of sensory information arriving from the perforant pathway (PP) to the hippocampus. The adequate integration of incoming information into the DG is paramount in the execution of hippocampal-dependent… read more here.
Keywords: contextual fear; gcl widening; fear memory; granule cell ... See more keywords
Considering the Role of Extracellular Matrix Molecules, in Particular Reelin, in Granule Cell Dispersion Related to Temporal Lobe Epilepsy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.917575
Abstract: The extracellular matrix (ECM) of the nervous system can be considered as a dynamically adaptable compartment between neuronal cells, in particular neurons and glial cells, that participates in physiological functions of the nervous system. It… read more here.
Keywords: extracellular matrix; role; granule cell; reelin ... See more keywords
Anatomical and Functional Connectivity at the Dendrodendritic Reciprocal Mitral Cell–Granule Cell Synapse: Impact on Recurrent and Lateral Inhibition
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neural Circuits"
DOI: 10.3389/fncir.2022.933201
Abstract: In the vertebrate olfactory bulb, reciprocal dendrodendritic interactions between its principal neurons, the mitral and tufted cells, and inhibitory interneurons in the external plexiform layer mediate both recurrent and lateral inhibition, with the most numerous… read more here.
Keywords: connectivity; cell; granule cell; lateral inhibition ... See more keywords
Morin Prevents Granule Cell Dispersion and Neurotoxicity via Suppression of mTORC1 in a Kainic Acid-induced Seizure Model
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Neurobiology"
DOI: 10.5607/en.2018.27.3.226
Abstract: An abnormal reorganization of the dentate gyrus and neurotoxic events are important phenotypes in the hippocampus of patients with temporal lobe epilepsy (TLE). The effects of morin, a bioflavonoid constituent of many herbs and fruits,… read more here.
Keywords: granule cell; cell dispersion; acid induced; mtorc1 ... See more keywords