Loss of tumor necrosis factor (TNF)‐receptor 1 and TNF‐receptor 2 partially replicate effects of TNF deficiency on dendritic spines of granule cells in mouse dentate gyrus
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.25424
Abstract: The cytokine tumor necrosis factor (TNF) is involved in the regulation of physiological and pathophysiological processes in the central nervous system. In previous work, we showed that mice lacking constitutive levels of TNF exhibit a… read more here.
Keywords: tnf receptor; tnf; granule; granule cells ... See more keywords
Neuroligin‐2 controls the establishment of fast GABAergic transmission in adult‐born granule cells
Sign Up to like & getrecommendations! Published in 2023 at "Hippocampus"
DOI: 10.1002/hipo.23505
Abstract: GABAergic inhibition is critical for the precision of neuronal spiking and the homeostatic regulation of network activity in the brain. Adult neurogenesis challenges network homeostasis because new granule cells (GCs) integrate continuously in the functional… read more here.
Keywords: fast gabaergic; adult; adult born; granule cells ... See more keywords
Oral exposure to aluminum chloride for 28 days suppresses neural stem cell proliferation and increases mature granule cells in adult hippocampal neurogenesis of young‐adult rats
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4299
Abstract: Aluminum (Al), a common light metal, affects the developing nervous system. Developmental exposure to Al chloride (AlCl3) induces aberrant neurogenesis by targeting neural stem cells (NSCs) and/or neural progenitor cells (NPCs) in the dentate gyrus… read more here.
Keywords: hippocampal neurogenesis; mature granule; exposure; granule cells ... See more keywords
Differential Coupling of Adult-Born Granule Cells to Parvalbumin and Somatostatin Interneurons
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2019.12.005
Abstract: SUMMARY A strong GABAergic tone imposes sparse levels of activity in the dentate gyrus of the hippocampus. This balance is challenged by the addition of new granule cells (GCs) with high excitability. How developing GCs… read more here.
Keywords: adult born; sst ins; granule cells; differential coupling ... See more keywords
Sparsification of AP firing in adult-born hippocampal granule cells via voltage-dependent α5-GABAA receptors.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109768
Abstract: GABA can depolarize immature neurons close to the action potential (AP) threshold in development and adult neurogenesis. Nevertheless, GABAergic synapses effectively inhibit AP firing in newborn granule cells of the adult hippocampus as early as… read more here.
Keywords: adult; hippocampal granule; voltage dependent; gabaa receptors ... See more keywords
Intrauterine growth restriction compromises cerebellar development by affecting radial migration of granule cells via the JamC/Pard3a molecular pathway
Sign Up to like & getrecommendations! Published in 2021 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2020.113537
Abstract: Intrauterine growth restriction (IUGR) affects ~10% of human pregnancies, results in infants born small for gestational age (SGA), and is associated with motor and cognitive deficits. Human studies suggest that some deficits in SGA patients… read more here.
Keywords: growth restriction; intrauterine growth; pard3a; jamc ... See more keywords
Enhanced postsynaptic inhibitory strength in hippocampal principal cells in high-performing aged rats
Sign Up to like & getrecommendations! Published in 2018 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2018.06.008
Abstract: Hyperactivity within the hippocampal formation, frequently observed in aged individuals, is thought to be a potential contributing mechanism to the memory decline often associated with aging. Consequently, we evaluated the postsynaptic strength of excitatory and… read more here.
Keywords: strength; inhibitory strength; enhanced postsynaptic; inhibitory ... See more keywords
Spatial Representations of Granule Cells and Mossy Cells of the Dentate Gyrus
Sign Up to like & getrecommendations! Published in 2017 at "Neuron"
DOI: 10.1016/j.neuron.2016.12.026
Abstract: Granule cells in the dentate gyrus of the hippocampus are thought to be essential to memory function by decorrelating overlapping input patterns (pattern separation). A second excitatory cell type in the dentate gyrus, the mossy cell,… read more here.
Keywords: cells dentate; dentate gyrus; representations granule; spatial representations ... See more keywords
Migrating and Nerve Fibers-Associated Eosinophilic Granule Cells in the Olfactory Organ of Catfish (Clarias garpienius): Light and Electron Microscopic Evidence
Sign Up to like & getrecommendations! Published in 2021 at "Microscopy and Microanalysis"
DOI: 10.1017/s1431927621012897
Abstract: Abstract Piscine mast cells or eosinophilic granule cells (EGCs) of fish are equivalent to the mammalian mast cells. Recently, a better understanding of EGCs functions is allowed because of the growing interest in fish models.… read more here.
Keywords: nerve; olfactory organ; eosinophilic granule; olfactory ... See more keywords
Cerebellar granule cells acquire a widespread predictive feedback signal during motor learning
Sign Up to like & getrecommendations! Published in 2017 at "Nature Neuroscience"
DOI: 10.1038/nn.4531
Abstract: Cerebellar granule cells, which constitute half the brain's neurons, supply Purkinje cells with contextual information necessary for motor learning, but how they encode this information is unknown. Here we show, using two-photon microscopy to track… read more here.
Keywords: cerebellar granule; motor learning; cells acquire; granule cells ... See more keywords
Congenital hypothyroidism impairs spine growth of dentate granule cells by downregulation of CaMKIV
Sign Up to like & getrecommendations! Published in 2021 at "Cell Death Discovery"
DOI: 10.1038/s41420-021-00530-z
Abstract: Congenital hypothyroidism (CH), a common neonatal endocrine disorder, can result in cognitive deficits if delay in diagnose and treatment. Dentate gyrus (DG) is the severely affected subregion of the hippocampus by the CH, where the… read more here.
Keywords: dentate granule; congenital hypothyroidism; dentate; spine growth ... See more keywords