A Ca2+-Dependent Switch Activates Axonal Casein Kinase 2α Translation and Drives G3BP1 Granule Disassembly for Axon Regeneration
Sign Up to like & getrecommendations! Published in 2020 at "Current Biology"
DOI: 10.1016/j.cub.2020.09.043
Abstract: The main limitation on axon regeneration in the peripheral nervous system (PNS) is the slow rate of regrowth. We recently reported that nerve regeneration can be accelerated by axonal G3BP1 granule disassembly, releasing axonal mRNAs… read more here.
Keywords: g3bp1 granule; regeneration; granule disassembly; translation ... See more keywords
β-propeller protein-associated neurodegeneration protein WDR45 regulates stress granule disassembly via phase separation with Caprin-1
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-60583-x
Abstract: β-propeller protein-associated neurodegeneration (BPAN) is a rare X-linked neurodegenerative disorder caused by mutations in the WDR45 gene, yet its molecular mechanisms remain poorly understood. Here, we identify a role for WDR45 in stress granule (SG)… read more here.
Keywords: stress granule; wdr45; protein; granule disassembly ... See more keywords