Functional hierarchy among different Rab27 effectors involved in secretory granule exocytosis
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DOI: 10.1101/2022.08.23.504970
Abstract: The Rab27 effectors play versatile roles in regulated exocytosis. In pancreatic beta cells, exophilin-8 anchors granules in the peripheral actin cortex, whereas granuphilin and melanophilin mediate granule fusion with and without stable docking to the… read more here.
Keywords: functional hierarchy; granule exocytosis; rab27 effectors; plasma membrane ... See more keywords
Pseudomonas aeruginosa modulates neutrophil granule exocytosis in an in vitro model of airway infection
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DOI: 10.1111/imcb.12547
Abstract: A population of neutrophils recruited into cystic fibrosis (CF) airways is associated with proteolytic lung damage, exhibiting high expression of primary granule exocytosis marker CD63 and reduced phagocytic receptor CD16. Causative factors for this population… read more here.
Keywords: granule exocytosis; pseudomonas aeruginosa; infection; model ... See more keywords
Cytotoxic Granule Exocytosis From Human Cytotoxic T Lymphocytes Is Mediated by VAMP7
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.01855
Abstract: Cytotoxic T lymphocytes kill infected or malignant cells through the directed release of cytotoxic substances at the site of target cell contact, the immunological synapse. While genetic association studies of genes predisposing to early-onset life-threatening… read more here.
Keywords: granule exocytosis; cytotoxic; fusion machinery; cytotoxic lymphocytes ... See more keywords
Molecular Docking and Dynamics Simulation Studies Predict Munc18b as a Target of Mycolactone: A Plausible Mechanism for Granule Exocytosis Impairment in Buruli Ulcer Pathogenesis
Sign Up to like & getrecommendations! Published in 2019 at "Toxins"
DOI: 10.3390/toxins11030181
Abstract: Ulcers due to infections with Mycobacterium ulcerans are characterized by complete lack of wound healing processes, painless, an underlying bed of host dead cells and undermined edges due to necrosis. Mycolactone, a macrolide produced by… read more here.
Keywords: granule exocytosis; mycolactone; buruli ulcer; exocytosis ... See more keywords