Biological Roles of Neutrophil-Derived Granule Proteins and Cytokines.
Sign Up to like & getrecommendations! Published in 2019 at "Trends in immunology"
DOI: 10.1016/j.it.2019.05.003
Abstract: Neutrophils, the most abundant white blood cells in human circulation, entertain intense interactions with other leukocyte subsets, platelets, and stromal cells. Molecularly, such interactions are typically communicated through proteins generated during granulopoiesis, stored in granules,… read more here.
Keywords: derived granule; proteins cytokines; roles neutrophil; neutrophil derived ... See more keywords
Distinct features of stress granule proteins predict localization in membraneless organelle.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2020.02.020
Abstract: Recently generated proteomic data provides unprecedented insight into stress granule composition and stands as fruitful ground for further analysis. Stress granules are stress-induced biological assemblies that are of keen interest due to being linked to… read more here.
Keywords: stress granule; membraneless; distinct features; granule proteins ... See more keywords
Functional Characterization of 15 Novel Dense Granule Proteins in Toxoplasma gondii Using the CRISPR-Cas9 System
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.03078-22
Abstract: Dense granule proteins (GRAs) play important roles in Toxoplasma gondii pathogenicity. However, the functions of many putative GRAs have not been elucidated. ABSTRACT The analysis of the subcellular localization and function of dense granule proteins… read more here.
Keywords: granule proteins; dense granule; gra genes; gondii ... See more keywords
Eosinophil granule proteins: what they can tell us about asthma
Sign Up to like & getrecommendations! Published in 2021 at "Thorax"
DOI: 10.1136/thoraxjnl-2021-218268
Abstract: Since their discovery by Paul Ehrlich in 1879, eosinophils have long been regarded to play a protective role against pathogens, especially during parasite infection. Contrary to other granulocytes, eosinophils contain four cationic and acid granule… read more here.
Keywords: eosinophil granule; edn ecp; edn; asthma ... See more keywords
Neutrophil Granule Proteins Inhibit Amyloid Beta Aggregation and Neurotoxicity.
Sign Up to like & getrecommendations! Published in 2021 at "Current Alzheimer research"
DOI: 10.2174/1567205018666210823095044
Abstract: BACKGROUND A role for neutrophils in the pathogenesis of Alzheimer's disease (AD) is emerging. We previously showed that the neutrophil granule proteins cationic antimicrobial protein of 37 kDa (CAP37), cathepsin G (CG), and neutrophil elastase… read more here.
Keywords: neutrophil granule; aggregation; inhibition aggregation; amyloid beta ... See more keywords
Peptides Derived From Insulin Granule Proteins Are Targeted by CD8+ T Cells Across MHC Class I Restrictions in Humans and NOD Mice
Sign Up to like & getrecommendations! Published in 2020 at "Diabetes"
DOI: 10.2337/db20-0013
Abstract: The antigenic peptides processed by β-cells and presented through surface HLA class I molecules are poorly characterized. Each HLA variant (e.g., the most common being HLA-A2 and HLA-A3) carries some peptide-binding specificity. Hence, features that,… read more here.
Keywords: cd8 cells; hla; proteins targeted; granule proteins ... See more keywords
Eosinophil Granule Proteins Involvement in Acute Appendicitis—An Allergic Disease?
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24109091
Abstract: Several pieces of evidence point to an allergic component as a trigger of acute appendicitis. As the Th2 immune response is characterized by eosinophil mobilization to the target organ and release of their cationic granule… read more here.
Keywords: acute appendicitis; granule proteins; serum; appendicitis ... See more keywords
Terminally Differentiating Eosinophils Express Neutrophil Primary Granule Proteins as well as Eosinophil-specific Granule Proteins in a Temporal Manner
Sign Up to like & getrecommendations! Published in 2017 at "Immune Network"
DOI: 10.4110/in.2017.17.6.410
Abstract: Neutrophils and eosinophils, 2 prominent granulocytes, are commonly derived from myelocytic progenitors through successive stages in the bone marrow. Our previous genome-wide transcriptomic data unexpectedly showed that genes encoding a multitude of neutrophil primary granule… read more here.
Keywords: primary granule; granule; eosinophil specific; npgp genes ... See more keywords