Folding of granulin domains
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DOI: 10.1002/pep2.24062
Abstract: Granulins are a family of protein growth factors that are involved in a range of biological functions, including wound repair, inflammation, and tumor growth. They are often expressed as part of large precursor proteins containing… read more here.
Keywords: folding granulin; granulin; family; granulin domains ... See more keywords
Large-Scale Generation of Recombinant Granulin Peptides in E. coli.
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DOI: 10.1007/978-1-4939-8559-3_4
Abstract: Generating milligram quantities of correctly folded granulin molecules with properly formed disulfide bonds and biologically relevant activities may represent a considerable challenge. Here I describe a protocol for obtaining well-folded human granulins A, C, and… read more here.
Keywords: large scale; generation recombinant; granulin; recombinant granulin ... See more keywords
Regulation of cathepsin D activity by the FTLD protein progranulin
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DOI: 10.1007/s00401-017-1719-5
Abstract: and suggest that PGRN and CTSD might function together to regulate lysosomal activities. In support of this hypothesis, granulin motifs are found in cathepsin-like cysteine proteases in plants [11, 16]. These lines of evidence led… read more here.
Keywords: pgrn ctsd; interaction pgrn; ctsd; granulin ... See more keywords
Structural brain splitting is a hallmark of Granulin-related frontotemporal dementia
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DOI: 10.1016/j.neurobiolaging.2022.02.009
Abstract: Frontotemporal dementia associated with granulin (GRN) mutations presents asymmetric brain atrophy. We applied a Minimum Spanning Tree plus an Efficiency Cost Optimization approach to cortical thickness data in order to test whether graph theory measures… read more here.
Keywords: structural brain; frontotemporal dementia; granulin; related frontotemporal ... See more keywords