Humanized 3F8 Anti-GD2 Monoclonal Antibody Dosing With Granulocyte-Macrophage Colony-Stimulating Factor in Patients With Resistant Neuroblastoma: A Phase 1 Clinical Trial
Sign Up to like & getrecommendations! Published in 2018 at "JAMA Oncology"
DOI: 10.1001/jamaoncol.2018.4005
Abstract: Importance Chimeric and murine anti-GD2 antibodies are active against neuroblastoma, but the development of neutralizing antibodies can compromise efficacy. To decrease immunogenicity, hu3F8, a humanized anti-GD2 antibody, was constructed. Objective To find the maximum-tolerated dose… read more here.
Keywords: trial; anti gd2; antibody; cycle ... See more keywords
Treatment of MCPT8DTR mice with high‐ or low‐dose diphtheria toxin leads to differential depletion of basophils and granulocyte‐macrophage progenitors
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Immunology"
DOI: 10.1002/eji.201747351
Abstract: Basophils have been recently recognized to play important roles in type 2 immune responses during allergies and parasitic infection, largely due to the development of novel tools for the in vivo study of these cells.… read more here.
Keywords: mcpt8dtr; macrophage progenitors; eosinophils neutrophils; mcpt8dtr mice ... See more keywords
UNC93B1 promotes tumoral growth by controlling the secretion level of granulocyte macrophage colony-stimulating factor in human oral cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.03.172
Abstract: Unc-93 homolog B1 (UNC93B1), a transmembrane protein, is correlated with immune diseases, such as influenza, herpes simplex encephalitis, and the pathogenesis of systemic lupus erythematosus; however, the role of UNC93B1 in cancers including human oral… read more here.
Keywords: stimulating factor; level; macrophage colony; colony stimulating ... See more keywords
Rationale and design of the granulocyte-macrophage colony stimulating factor in peripheral arterial disease (GPAD-3) study.
Sign Up to like & getrecommendations! Published in 2020 at "Contemporary clinical trials"
DOI: 10.1016/j.cct.2020.105975
Abstract: BACKGROUND Lower extremity peripheral arterial disease (PAD) is a public health problem and many patients with PAD experience claudication despite adequate medical and/or surgical management. Mobilization of endogenous progenitor cells using Granulocyte-Macrophage Colony Stimulating Factor… read more here.
Keywords: study; macrophage colony; colony stimulating; peripheral arterial ... See more keywords
Practically feasible production of sustained‐release microspheres of granulocyte‐macrophage colony‐stimulating factor (rhGM‐CSF)
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Controlled Release"
DOI: 10.1016/j.jconrel.2017.04.004
Abstract: ABSTRACT Using recombinant human granulocyte‐macrophage colony‐stimulating factor (rhGM‐CSF) as a model drug, the present study demonstrated a practically feasible process to produce polymeric microspheres for sustained‐release delivery of protein drugs with preserved integrity. This process… read more here.
Keywords: release; macrophage colony; practically feasible; rhgm csf ... See more keywords
Macrophage Distribution Affected by Virus-Encoded Granulocyte Macrophage Colony Stimulating Factor Combined with Lactate Oxidase
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c03213
Abstract: Oncolytic virotherapy was approved as a localized treatment for advanced melanoma by the US Food and Drug Administration (FDA) in 2015. Granulocyte macrophage colony stimulating factor (GM-CSF) encoded by clinical virus-infected tumor cells, acting as… read more here.
Keywords: granulocyte macrophage; virus; factor; macrophage colony ... See more keywords
Autoantibodies to Granulocyte-Macrophage Colony-Stimulating Factor Associated With Severe and Unusual Manifestations of Cryptococcus gattii Infections
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DOI: 10.1093/ofid/ofx211
Abstract: Abstract Cryptococcus gattii infections, especially including those with severe clinical manifestations, may be related to underlying host immunologic factors. We present 2 cases with autoantibodies to granulocyte-macrophage colony-stimulating factor (GM-CSF), a key cytokine in macrophage… read more here.
Keywords: gattii infections; macrophage colony; cryptococcus gattii; autoantibodies granulocyte ... See more keywords
Disseminated cryptococcosis and anti‐granulocyte‐macrophage colony‐stimulating factor autoantibodies: An underappreciated association
Sign Up to like & getrecommendations! Published in 2021 at "Mycoses"
DOI: 10.1111/myc.13247
Abstract: The development of disseminated cryptococcosis has historically occurred in patients living with advanced human immunodeficiency virus or other immunosuppressive conditions affecting T‐cell function. Recently, patients with anti‐cytokine neutralising autoantibodies have been recognised to be at… read more here.
Keywords: anti granulocyte; disseminated cryptococcosis; cryptococcosis; macrophage colony ... See more keywords
Splenic Innate B1 B Cell Plasmablasts Produce Sustained Granulocyte-Macrophage Colony-Stimulating Factor and Interleukin-3 Cytokines during Murine Malaria Infections
Sign Up to like & getrecommendations! Published in 2019 at "Infection and Immunity"
DOI: 10.1128/iai.00482-19
Abstract: The physiopathology of malaria, one of the most deadly human parasitic diseases worldwide, is complex, as it is a systemic disease involving multiple parasitic stages and hosts and leads to the activation of numerous immune… read more here.
Keywords: innate; csf; granulocyte macrophage; cell ... See more keywords
Anti-Granulocyte–Macrophage Colony–Stimulating Factor Monoclonal Antibody Gimsilumab for COVID-19 Pneumonia: A Randomized, Double-Blind, Placebo-controlled Trial
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Respiratory and Critical Care Medicine"
DOI: 10.1164/rccm.202108-1859oc
Abstract: Rationale GM-CSF (granulocyte–macrophage colony–stimulating factor) has emerged as a promising target against the hyperactive host immune response associated with coronavirus disease (COVID-19). Objectives We sought to investigate the efficacy and safety of gimsilumab, an anti–GM-CSF… read more here.
Keywords: gimsilumab; granulocyte macrophage; trial; placebo ... See more keywords
Granulocyte-macrophage colony-stimulating factor increases tumor growth and angiogenesis directly by promoting endothelial cell function and indirectly by enhancing the mobilization and recruitment of proangiogenic granulocytes
Sign Up to like & getrecommendations! Published in 2017 at "Tumor Biology"
DOI: 10.1177/1010428317692232
Abstract: Granulocyte-macrophage colony-stimulating factor has been widely used as an adjuvant therapy for cancer patients exhibiting myelosuppression induced by chemotherapy or radiotherapy. However, the effects of granulocyte-macrophage colony-stimulating factor on tumor growth, as well as its… read more here.
Keywords: stimulating factor; macrophage colony; colony stimulating; factor ... See more keywords