The stage‐specific impairment of granulopoiesis in people living with HIV/AIDS (PLWHA) with neutropenia
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DOI: 10.1002/jlb.1a0120-414r
Abstract: Neutropenia and impaired functions were common manifestation in antiretroviral therapy (ART) in both naïve and experienced PLWHA. Granulopoiesis can be divided into two phases: lineage determination and committed granulopoiesis. However, stage‐specific impairment of granulopoiesis in… read more here.
Keywords: art experienced; art; segmented neutrophils; stage specific ... See more keywords
Switch of Steady-State to an Accelerated Granulopoiesis in Response to Androctonus australis hector Venom
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DOI: 10.1007/s10753-017-0532-6
Abstract: Although several studies have shown that scorpion venoms cause a systemic inflammatory response syndrome, little is known about the contribution of the hematopoietic organs. The aim of this study was to investigate the effect of… read more here.
Keywords: state; response; androctonus australis; australis hector ... See more keywords
A SMARCD2-containing mSWI/SNF complex is required for granulopoiesis
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DOI: 10.1038/ng.3853
Abstract: Mammalian SWI/SNF complexes have critical roles in development and differentiation, and are implicated in the pathogenesis of several diseases; however, the mechanisms underpinning disease manifestation and the specificity of the subunits mutated are incompletely understood.… read more here.
Keywords: smarcd2 containing; mswi snf; snf complex; granulopoiesis ... See more keywords
ELF-MF exposure affects the robustness of epigenetic programming during granulopoiesis
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DOI: 10.1038/srep43345
Abstract: Extremely-low-frequency magnetic fields (ELF-MF) have been classified as “possibly carcinogenic” to humans on the grounds of an epidemiological association of ELF-MF exposure with an increased risk of childhood leukaemia. Yet, underlying mechanisms have remained obscure.… read more here.
Keywords: robustness epigenetic; exposure; exposure affects; granulopoiesis ... See more keywords
Shigella-Induced Emergency Granulopoiesis Protects Zebrafish Larvae from Secondary Infection
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DOI: 10.1128/mbio.00933-18
Abstract: ABSTRACT Emergency granulopoiesis is a hematopoietic program of stem cell-driven neutrophil production used to counteract immune cell exhaustion following infection. Shigella flexneri is a Gram-negative enteroinvasive pathogen controlled by neutrophils. In this study, we use… read more here.
Keywords: infection; shigella; emergency granulopoiesis; stem ... See more keywords
Oral intake of lipopolysaccharide regulates toll-like receptor 4-dependent granulopoiesis
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DOI: 10.1177/1535370220931043
Abstract: While neutrophil production in emergency states has been extensively studied, regulation of neutrophil homeostasis in the steady-state remained incompletely understood. We have shown that innate immune receptor toll-like receptor (TLR)4 and downstream TIR-domain-containing adapter-inducing interferon-β… read more here.
Keywords: oral intake; steady state; receptor; granulopoiesis ... See more keywords
Erythroblastic islands foster granulopoiesis in parallel to terminal erythropoiesis.
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DOI: 10.1182/blood.2022015724
Abstract: The erythroblastic island (EBI), composed of a central macrophage surrounded by maturing erythroblasts, is the erythroid precursor niche. Despite numerous studies, its precise composition is still unclear. Using multispectral imaging flow cytometry (IFC), in vitro… read more here.
Keywords: granulopoiesis; terminal erythropoiesis; bone marrow; erythropoiesis ... See more keywords
The blood‐borne sialyltransferase ST6Gal‐1 is a negative systemic regulator of granulopoiesis
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DOI: 10.1189/jlb.3a1216-538rr
Abstract: Responding to systemic demands in producing and replenishing end‐effector blood cells is predicated on the appropriate delivery and interpretation of extrinsic signals to the HSPCs. The data presented herein implicate the systemic, extracellular form of… read more here.
Keywords: negative systemic; st6gal negative; regulator granulopoiesis; blood ... See more keywords
Regulation of emergency granulopoiesis during infection
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DOI: 10.3389/fimmu.2022.961601
Abstract: During acute infectious and inflammatory conditions, a large number of neutrophils are in high demand as they are consumed in peripheral organs. The hematopoietic system rapidly responds to the demand by turning from steady state… read more here.
Keywords: granulopoiesis; regulation emergency; emergency granulopoiesis; granulopoiesis infection ... See more keywords