Ameliorative potential of vitamin C and E against Roundup‐glyphosate induced genotoxicity triggering apoptosis in caprine granulosa cells
Sign Up to like & getrecommendations! Published in 2022 at "Environmental and Molecular Mutagenesis"
DOI: 10.1002/em.22497
Abstract: The present study was aimed to investigate the genotoxic and apoptotic effects of glyphosate (GLP) in Roundup formulation along with mitigation of two potent antioxidants that is, vitamin C and E in caprine granulosa cells… read more here.
Keywords: induced genotoxicity; roundup; caprine granulosa; granulosa ... See more keywords
Hemodynamic, endocrine, and gene expression mechanisms regulating equine ovarian follicular and cellular development
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Reproduction and Development"
DOI: 10.1002/mrd.23549
Abstract: Ovulatory follicle development and associated oocyte maturation involve complex coordinated molecular and cellular mechanisms not yet fully understood. This study addresses the relationships among follicle diameter, follicle wall blood flow, follicular‐fluid factors, and gene expression… read more here.
Keywords: development; granulosa; gene expression; follicle ... See more keywords
Serum Lipids Maintain Granulosa Cell Membrane Structure in Antral Follicles During Warming/Thawing of Vitrified Mice Ovaries
Sign Up to like & getrecommendations! Published in 2025 at "Reproductive Medicine and Biology"
DOI: 10.1002/rmb2.12687
Abstract: ABSTRACT Purpose We demonstrated that briefly treating ovaries with collagenase before exposure to a hyperosmotic solution preserved secondary follicles. However, preserving antral follicles remained difficult. We investigated whether the absence of lipids in warming (thawing)… read more here.
Keywords: cell membrane; function; cell; granulosa ... See more keywords
N‐acetyl cysteine‐mediated effective attenuation of methoxychlor‐induced granulosa cell apoptosis by counteracting reactive oxygen species generation in caprine ovary
Sign Up to like & getrecommendations! Published in 2017 at "Environmental Toxicology"
DOI: 10.1002/tox.22221
Abstract: Methoxychlor (MXC), an organochloride insecticide, is a potent toxicant‐targeting female reproductive system and known to cause follicular atresia by inducing apoptosis within granulosa cells. Oxidative stress plays a pivotal role in apoptosis; thus, this study… read more here.
Keywords: granulosa; apoptosis; caprine ovary; granulosa cell ... See more keywords
Kurarinone attenuates hydrogen peroxide‐induced oxidative stress and apoptosis through activating the PI3K/Akt signaling by upregulating IGF1 expression in human ovarian granulosa cells
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23659
Abstract: Dysregulated follicular development may lead to follicular atresia, and this is associated with oxidative stress in granulosa cells. Kurarinone is a natural compound possessing multiple activities, including antioxidative ability. However, the role of kurarinone in… read more here.
Keywords: stress; apoptosis; cells kurarinone; oxidative stress ... See more keywords
Apelin abrogates the stimulatory effects of 17β-estradiol and insulin-like growth factor-1 on proliferation of epithelial and granulosa ovarian cancer cell lines via crosstalk between APLNR and ERα/IGF1R
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Biology Reports"
DOI: 10.1007/s11033-019-05073-2
Abstract: Apelin and chemerin are adipocytokines that play important roles in many physiological and pathological processes throughout the body. Our previous study demonstrated that these two adipokines are expressed and secreted by epithelial and granulosa cancer… read more here.
Keywords: granulosa; apelin; cell lines; proliferation ... See more keywords
Transcriptional profiling of porcine granulosa cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Sign Up to like & getrecommendations! Published in 2017 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2017.03.055
Abstract: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a toxic man-made chemical compound contaminating the environment. An exposure of living organisms to TCDD may result in numerous disorders, including reproductive pathologies. The aim of the current study was to examine… read more here.
Keywords: porcine granulosa; granulosa cells; tetrachlorodibenzo dioxin; granulosa ... See more keywords
Overexpression of CDC25C affects the cell cycle of ovarian granulosa cells from adult and young goats
Sign Up to like & getrecommendations! Published in 2018 at "Electronic Journal of Biotechnology"
DOI: 10.1016/j.ejbt.2017.10.008
Abstract: Background: CDC25 is a dual-specificity phosphatase that was first identified in the yeast Schizosaccharomyces pombe as a cell cycle-defective mutant. Although CDC25 is involved in the cell cycle of ovarian granulosa cells, the CDC25 signaling… read more here.
Keywords: ovarian granulosa; granulosa cells; granulosa; cdc25c ... See more keywords
Resveratrol depolarizes the membrane potential in human granulosa cells and promotes mitochondrial biogenesis.
Sign Up to like & getrecommendations! Published in 2021 at "Fertility and sterility"
DOI: 10.1016/j.fertnstert.2020.08.016
Abstract: OBJECTIVE To study the biological effects of resveratrol on the growth, electrophysiology, and mitochondrial function of human granulosa cells (h-GCs). DESIGN Preclinical study. SETTING Electrophysiology laboratory and in vitro fertilization unit. PATIENT(S) This study included h-GCs… read more here.
Keywords: granulosa cells; resveratrol; mitochondrial biogenesis; granulosa ... See more keywords
TGF-β1 resulting in differential microRNA expression in bovine granulosa cells.
Sign Up to like & getrecommendations! Published in 2018 at "Gene"
DOI: 10.1016/j.gene.2018.04.036
Abstract: To explore the expression profile of the cellular miRNAs in bovine ovarian granulosa cells responding to transforming growth factor-β1 (TGF-β1), the effect of TGF-β1 on cell proliferation was firstly investigated by CCK-8 method and the… read more here.
Keywords: granulosa cells; bovine granulosa; granulosa; tgf ... See more keywords
SOD2 deficiency-induced oxidative stress attenuates steroidogenesis in mouse ovarian granulosa cells
Sign Up to like & getrecommendations! Published in 2021 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2020.110888
Abstract: This study investigated the effects of SOD2 (MnSOD)-deficiency-induced excessive oxidative stress on ovarian steroidogenesis in vivo and isolated and cultured granulosa cells using WT and Sod2 ± mice. Basal and 48 h eCG-stimulated plasma progesterone levels were decreased… read more here.
Keywords: granulosa cells; granulosa; sod2 deficiency; oxidative stress ... See more keywords