CDK4/6 inhibitor protects chemerin‐induced human granulosa‐lutein cells from apoptosis by inhibiting the p53/p21 waf pathway
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Reproduction and Development"
DOI: 10.1002/mrd.23241
Abstract: Dysregulation of the cell cycle is common in human tumorigenesis. Therefore, CDK4/6 inhibitors targeting the cell cycle have been developed, and their antiapoptotic effects have been highly correlated with potential clinical therapies. The aim of… read more here.
Keywords: cdk4 inhibitor; hgl cells; chemerin induced; granulosa lutein ... See more keywords
Divergent roles of sirtuin 1 in human granulosa-lutein cells: similarities to human chorionic gonadotropin
Sign Up to like & getrecommendations! Published in 2023 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioad026
Abstract: Abstract Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide–dependent deacetylase that modifies gene expression through histone deacetylation. It also deacetylates nonhistone substrates, e.g., tumor suppressor p53, NOS3, HIF1A, NFKB, FOXO3a, PGC-1α, and PPARγ . Consequently,… read more here.
Keywords: granulosa lutein; human granulosa; camp; granulosa ... See more keywords
ALK2/ALK3‐BMPR2/ACVR2A Mediate BMP2‐Induced Downregulation of Pentraxin 3 Expression in Human Granulosa‐Lutein Cells
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DOI: 10.1210/en.2017-00436
Abstract: &NA; Bone morphogenetic protein 2 (BMP2) belongs to the transforming growth factor‐&bgr; superfamily and plays a critical role in regulating ovarian follicle function. Currently, the role of BMP2 during cumulus expansion remains to be determined.… read more here.
Keywords: bmp2; expression; human granulosa; granulosa lutein ... See more keywords
Resveratrol attenuates hydrogen peroxide-induced injury of rat ovarian granulosa-lutein cells by resisting oxidative stress via the SIRT1/Nrf2/ARE signaling pathway.
Sign Up to like & getrecommendations! Published in 2023 at "Current pharmaceutical design"
DOI: 10.2174/1381612829666230403133322
Abstract: AIMS This paper aims to reveal the molecular mechanism of resveratrol against oxidative stress and cell injury. INTRODUCTION The ovarian granulosa-lutein cell injury and apoptosis induced by oxidative stress may be responsible for female luteal… read more here.
Keywords: granulosa lutein; oxidative stress; ovarian granulosa; resveratrol ... See more keywords
Granulosa-Lutein Cell Sirtuin Gene Expression Profiles Differ between Normal Donors and Infertile Women
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21010295
Abstract: Sirtuins are a family of deacetylases that modify structural proteins, metabolic enzymes, and histones to change cellular protein localization and function. In mammals, there are seven sirtuins involved in processes like oxidative stress or metabolic… read more here.
Keywords: lutein cell; gene expression; expression; granulosa lutein ... See more keywords