Activatable Sonoafterglow Nanoprobes for T cell Imaging.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced materials"
DOI: 10.1002/adma.202211651
Abstract: Real-time imaging of immune system benefits early diagnosis of disease and precision immunotherapy; however, most existing imaging probes either have "always-on" signals with poor correlation to immune responses, or rely on light excitation with limited… read more here.
Keywords: cell imaging; granzyme; nanoprobes cell; activatable sonoafterglow ... See more keywords
Identification and annotation of bovine granzyme genes reveals a novel granzyme encoded within the trypsin-like locus
Sign Up to like & getrecommendations! Published in 2018 at "Immunogenetics"
DOI: 10.1007/s00251-018-1062-6
Abstract: Granzymes are a family of serine proteases found in the lytic granules of cytotoxic T lymphocytes and natural killer (NK) cells, which are involved in killing of susceptible target cells. Most information on granzymes and… read more here.
Keywords: trypsin like; granzyme genes; annotation bovine; granzyme ... See more keywords
Cytotoxic T Lymphocyte Granzyme-b mediates neuronal cell death during Plasmodium berghei ANKA induced experimental cerebral malaria
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2017.11.021
Abstract: Cerebral malaria is a complex, acute, neurological disease characterised by a sudden onset of cerebral symptoms. This disease is manifested as initial arousable stage that is followed by an unarousable coma and eventually death. Parasite… read more here.
Keywords: death; cytotoxic lymphocyte; granzyme; experimental cerebral ... See more keywords
High expression of granzyme B in conventional CD4+ T cells is associated with increased relapses after allogeneic stem cells transplantation in patients with hematological malignancies.
Sign Up to like & getrecommendations! Published in 2020 at "Transplant immunology"
DOI: 10.1016/j.trim.2020.101295
Abstract: Granzyme B is known to be a serine protease contained in granules of cytotoxic T cells. We have previously reported an influence of granzyme B expression in T regulatory cells (Tregs) on the risk of… read more here.
Keywords: allo hsct; conventional cells; transplantation; expression ... See more keywords
Density of tumor-infiltrating granzyme B-positive cells predicts favorable prognosis in dogs with transitional cell carcinoma.
Sign Up to like & getrecommendations! Published in 2017 at "Veterinary immunology and immunopathology"
DOI: 10.1016/j.vetimm.2017.07.001
Abstract: Although tumor-infiltrating lymphocytes (TILs) play a key role in anti-tumor immunity, their involvement in canine transitional cell carcinoma (TCC) is not well-documented. The objective of this study was to investigate the association between TIL number… read more here.
Keywords: transitional cell; prognosis; tumor infiltrating; granzyme ... See more keywords
Granzyme B as a therapeutic target for wound healing
Sign Up to like & getrecommendations! Published in 2019 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2019.1661380
Abstract: ABSTRACT Introduction: Granzyme B is a serine protease traditionally understood as having a role in immune-mediated cytotoxicity. Over the past decade, this dogma has been challenged, with a new appreciation that granzyme B can exert… read more here.
Keywords: target wound; wound healing; granzyme inhibitors; granzyme ... See more keywords
Granzyme K+ CD8 T cells form a core population in inflamed human tissue
Sign Up to like & getrecommendations! Published in 2022 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abo0686
Abstract: T cell–derived pro-inflammatory cytokines are a major driver of rheumatoid arthritis (RA) pathogenesis. Although these cytokines have traditionally been attributed to CD4 T cells, we have found that CD8 T cells are notably abundant in… read more here.
Keywords: cell; cd8; granzyme; cd8 cells ... See more keywords
Therapeutical Significance of Serpina3n Subsequent Cerebral Ischemia via Cytotoxic Granzyme B Inactivation
Sign Up to like & getrecommendations! Published in 2022 at "BioMed Research International"
DOI: 10.1155/2022/1557010
Abstract: Ischemic stroke is a devastating CNS insult with few clinical cures. Poor understanding of underlying mechanistic network is the primary limitation to develop novel curative therapies. Extracellular accumulation of granzyme B subsequent ischemia promotes neurodegeneration.… read more here.
Keywords: subsequent cerebral; granzyme inactivation; cerebral ischemia; granzyme ... See more keywords
Expression of intra- and extracellular granzymes in patients with typhoid fever
Sign Up to like & getrecommendations! Published in 2017 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0005823
Abstract: Background Typhoid fever, caused by the intracellular pathogen Salmonella (S.) enterica serovar Typhi, remains a major cause of morbidity and mortality worldwide. Granzymes are serine proteases promoting cytotoxic lymphocytes mediated eradication of intracellular pathogens via… read more here.
Keywords: typhoid fever; expression; granzyme; granzymes patients ... See more keywords
Granzyme K initiates IL-6 and IL-8 release from epithelial cells by activating protease-activated receptor 2
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0270584
Abstract: Granzyme K (GzmK) is a tryptic member of the granzyme family of chymotrypsin-like serine proteases produced by cells of the immune system. Previous studies have indicated that GzmK activates protease-activated receptor 1 (PAR1) enhancing activation… read more here.
Keywords: protease activated; granzyme; gzmk; receptor ... See more keywords
Granzyme B: A novel therapeutic target for treatment of atopic dermatitis.
Sign Up to like & getrecommendations! Published in 2022 at "Indian journal of dermatology, venereology and leprology"
DOI: 10.25259/ijdvl_260_2022
Abstract: Granzyme B is a serine protease that can play multiple roles in intracellular and extracellular perforin-dependent or non-perforin-dependent mechanisms. Granzyme B has been found to be an important factor involved in the pathogenesis of atopic… read more here.
Keywords: novel therapeutic; granzyme; atopic; atopic dermatitis ... See more keywords