Articles with "granzyme perforin" as a keyword



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Primary Tr1 cells from metastatic melanoma eliminate tumor-promoting macrophages through granzyme B- and perforin-dependent mechanisms

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Published in 2017 at "Tumor Biology"

DOI: 10.1177/1010428317697554

Abstract: In malignant melanoma, tumor-associated macrophages play multiple roles in promoting tumor growth, such as inducing the transformation of melanocytes under ultraviolet irradiation, increasing angiogenesis in melanomas, and suppressing antitumor immunity. Because granzyme B- and perforin-expressing… read more here.

Keywords: melanoma; granzyme perforin; tr1 cells; promoting macrophages ... See more keywords