Pharmacokinetics and estimated bioavailability of grapiprant, a novel selective prostaglandin E2 receptor antagonist, after oral administration in fasted and fed dogs
Sign Up to like & getrecommendations! Published in 2017 at "New Zealand Veterinary Journal"
DOI: 10.1080/00480169.2016.1241727
Abstract: Abstract AIMS: To assess the effect of food intake on the pharmacokinetics of grapiprant administered orally at 2 mg/kg, and to estimate its oral bioavailability in dogs. METHODS: Eight healthy female Labrador Retriever dogs, aged 4–10… read more here.
Keywords: administration; fed dogs; grapiprant; estimated bioavailability ... See more keywords
Delayed blockage of prostaglandin EP4 receptors can reduce dedifferentiation, epithelial‐to‐mesenchymal transition and fibrosis following acute kidney injury
Sign Up to like & getrecommendations! Published in 2021 at "Clinical and Experimental Pharmacology and Physiology"
DOI: 10.1111/1440-1681.13478
Abstract: Dedifferentiation of tubular epithelial cells is involved in both regeneration and fibrosis following acute kidney injury (AKI). Prostaglandin E2 receptor 4 (EP4) antagonist can inhibit the dedifferentiation of renal tubular cells. The present study investigated… read more here.
Keywords: intervention; fibrosis; grapiprant; following acute ... See more keywords
Absorption of grapiprant in red-tailed hawks (Buteo jamaicensis) is decreased when administered with food.
Sign Up to like & getrecommendations! Published in 2022 at "American journal of veterinary research"
DOI: 10.2460/ajvr.21.10.0170
Abstract: OBJECTIVE Describe the pharmacokinetics of grapiprant administered orally with food to red-tailed hawks (RTHAs; Buteo jamaicensis) and compare the results with previously described grapiprant pharmacokinetics administered without food in this species. ANIMALS 6 healthy adult… read more here.
Keywords: buteo jamaicensis; grapiprant; food; plasma concentrations ... See more keywords