Therapeutic Potential of Targeting Periostin in the Treatment of Graves’ Orbitopathy
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DOI: 10.3389/fendo.2022.900791
Abstract: Periostin is a matricellular protein that is ubiquitously expressed in normal human tissues and is involved in pathologic mechanism of chronic inflammatory and fibrotic disease. In this study we investigate periostin in the pathogenesis of… read more here.
Keywords: periostin; orbital tissues; graves orbitopathy; graves orbital ... See more keywords
JNK and p38 Inhibitors Prevent Transforming Growth Factor-β1-Induced Myofibroblast Transdifferentiation in Human Graves’ Orbital Fibroblasts
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DOI: 10.3390/ijms22062952
Abstract: Transforming growth factor-β1 (TGF-β1)-induced myofibroblast transdifferentiation from orbital fibroblasts is known to dominate tissue remodeling and fibrosis in Graves’ ophthalmopathy (GO). However, the signaling pathways through which TGF-β1 activates Graves’ orbital fibroblasts remain unclear. This… read more here.
Keywords: graves orbital; orbital fibroblasts; growth factor; induced myofibroblast ... See more keywords