Integrating Multiplex Single-Molecule Pull-Down (SiMPull) Data and Computational Modeling to Understand EGFR Signaling
Sign Up to like & getrecommendations! Published in 2018 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2017.11.2554
Abstract: The Epidermal Growth Factor Receptor (EGFR) plays an important role in both physiological and cancerrelated processes. To study the factors that influence EGFR phosphorylation, we have coupled single-molecule microscopy experiments with rule-based modeling of EGFR… read more here.
Keywords: egfr; single molecule; egfr signaling; grb2 ... See more keywords
A two-component protein condensate of the EGFR cytoplasmic tail and Grb2 regulates Ras activation by SOS at the membrane
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2122531119
Abstract: Significance Two-dimensional condensates of proteins on the membrane surface, driven by tyrosine phosphorylation, are beginning to emerge as important players in signal transduction. This work describes discovery of a protein condensation phase transition of EGFR… read more here.
Keywords: grb2; protein condensate; component protein; two component ... See more keywords
GRB2 enforces homology-directed repair initiation by MRE11
Sign Up to like & getrecommendations! Published in 2021 at "Science Advances"
DOI: 10.1126/sciadv.abe9254
Abstract: GRB2 controls radiation-induced DNA damage repair—a predictive biomarker for PARPi and radiation therapy outcome. DNA double-strand break (DSB) repair is initiated by MRE11 nuclease for both homology-directed repair (HDR) and alternative end joining (Alt-EJ). Here,… read more here.
Keywords: directed repair; hdr; homology directed; grb2 ... See more keywords
The Role of Grb2 in Cancer and Peptides as Grb2 Antagonists.
Sign Up to like & getrecommendations! Published in 2018 at "Protein and peptide letters"
DOI: 10.2174/0929866525666171123213148
Abstract: BACKGROUND Growth factor receptor-bound protein 2 (Grb2) is a 25 kDa adaptor protein, which was originally discovered to accomplish basic cellular events such as cell growth, cell proliferation, and metabolism. However, recent studies evidenced that… read more here.
Keywords: protein; role grb2; peptides grb2; grb2 ... See more keywords
Grb2 Induces Cardiorenal Syndrome Type 3: Roles of IL-6, Cardiomyocyte Bioenergetics, and Akt/mTOR Pathway
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.630412
Abstract: Cardiorenal syndrome type 3 (CRS-3) is damage to the heart following acute kidney injury (AKI). Although many experiments have found that inflammation, oxidative stress, and cardiomyocyte death are involved in cardiomyocyte pathophysiological alterations during CRS-3,… read more here.
Keywords: cardiorenal syndrome; akt mtor; grb2; syndrome type ... See more keywords
The possible correlation between serum GRB2 levels and carotid atherosclerosis in patients with type 2 diabetes mellitus
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.963191
Abstract: Background and purpose Growth factor receptor-bound protein 2(GRB2), a bridging protein. An animal study showed that downregulation of GRB2 inhibited the activation of PI3K/AKT/NF-kB pathway which improved lipid accumulation and inflammatory infiltration in rats with… read more here.
Keywords: grb2; grb2 levels; group; t2dm ... See more keywords