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   Articles with "grb2" as a keyword



Integrating Multiplex Single-Molecule Pull-Down (SiMPull) Data and Computational Modeling to Understand EGFR Signaling

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recommendations! Published in 2018 at "Biophysical Journal"

DOI: 10.1016/j.bpj.2017.11.2554

Abstract: The Epidermal Growth Factor Receptor (EGFR) plays an important role in both physiological and cancerrelated processes. To study the factors that influence EGFR phosphorylation, we have coupled single-molecule microscopy experiments with rule-based modeling of EGFR… read more here.

Keywords: egfr; single molecule; egfr signaling; grb2 ... See more keywords

A two-component protein condensate of the EGFR cytoplasmic tail and Grb2 regulates Ras activation by SOS at the membrane

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recommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2122531119

Abstract: Significance Two-dimensional condensates of proteins on the membrane surface, driven by tyrosine phosphorylation, are beginning to emerge as important players in signal transduction. This work describes discovery of a protein condensation phase transition of EGFR… read more here.

Keywords: grb2; protein condensate; component protein; two component ... See more keywords

ROR1 facilitates glioblastoma growth via stabilizing GRB2 to promote c-Fos expression in glioma stem cells

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recommendations! Published in 2024 at "Neuro-Oncology"

DOI: 10.1093/neuonc/noae224

Abstract: Abstract Background Glioma stem cells (GSCs) are the root cause of tumorigenesis, recurrence, and therapeutic resistance in glioblastoma (GBM), the most prevalent and lethal type of primary adult brain malignancy. The exploitation of novel methods… read more here.

Keywords: fos; glioma stem; grb2; stem cells ... See more keywords

GRB2 enforces homology-directed repair initiation by MRE11

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recommendations! Published in 2021 at "Science Advances"

DOI: 10.1126/sciadv.abe9254

Abstract: GRB2 controls radiation-induced DNA damage repair—a predictive biomarker for PARPi and radiation therapy outcome. DNA double-strand break (DSB) repair is initiated by MRE11 nuclease for both homology-directed repair (HDR) and alternative end joining (Alt-EJ). Here,… read more here.

Keywords: directed repair; hdr; homology directed; grb2 ... See more keywords

The Role of Grb2 in Cancer and Peptides as Grb2 Antagonists.

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recommendations! Published in 2018 at "Protein and peptide letters"

DOI: 10.2174/0929866525666171123213148

Abstract: BACKGROUND Growth factor receptor-bound protein 2 (Grb2) is a 25 kDa adaptor protein, which was originally discovered to accomplish basic cellular events such as cell growth, cell proliferation, and metabolism. However, recent studies evidenced that… read more here.

Keywords: protein; role grb2; peptides grb2; grb2 ... See more keywords
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Grb2 Induces Cardiorenal Syndrome Type 3: Roles of IL-6, Cardiomyocyte Bioenergetics, and Akt/mTOR Pathway

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recommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"

DOI: 10.3389/fcell.2021.630412

Abstract: Cardiorenal syndrome type 3 (CRS-3) is damage to the heart following acute kidney injury (AKI). Although many experiments have found that inflammation, oxidative stress, and cardiomyocyte death are involved in cardiomyocyte pathophysiological alterations during CRS-3,… read more here.

Keywords: cardiorenal syndrome; akt mtor; grb2; syndrome type ... See more keywords

The possible correlation between serum GRB2 levels and carotid atherosclerosis in patients with type 2 diabetes mellitus

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recommendations! Published in 2022 at "Frontiers in Endocrinology"

DOI: 10.3389/fendo.2022.963191

Abstract: Background and purpose Growth factor receptor-bound protein 2(GRB2), a bridging protein. An animal study showed that downregulation of GRB2 inhibited the activation of PI3K/AKT/NF-kB pathway which improved lipid accumulation and inflammatory infiltration in rats with… read more here.

Keywords: grb2; grb2 levels; group; t2dm ... See more keywords

The Configuration of GRB2 in Protein Interaction and Signal Transduction

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recommendations! Published in 2024 at "Biomolecules"

DOI: 10.3390/biom14030259

Abstract: Growth-factor-receptor-binding protein 2 (GRB2) is a non-enzymatic adaptor protein that plays a pivotal role in precisely regulated signaling cascades from cell surface receptors to cellular responses, including signaling transduction and gene expression. GRB2 binds to… read more here.

Keywords: transduction; grb2 protein; grb2; configuration grb2 ... See more keywords

Shc1 cooperates with Frs2 and Shp2 to recruit Grb2 in FGF-induced lens development

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recommendations! Published in 2025 at "eLife"

DOI: 10.7554/elife.103615

Abstract: Fibroblast growth factor (FGF) signaling elicits multiple downstream pathways, most notably the Ras/MAPK cascade facilitated by the adaptor protein Grb2. However, the mechanism by which Grb2 is recruited to the FGF signaling complex remains unresolved.… read more here.

Keywords: frs2 shp2; grb2; fgf signaling; lens development ... See more keywords